Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 3, 2009, Pages 196-202

  Greene, Michael ^a,b   Thackeray, James T ^a,b   Kenk, Miran ^a,b   Thorn, Stephanie L ^a,b   Bevilacqua, Lisa ^b   Harper, Mary Ellen ^b   Beanlands, Rob S ^a,b   Dasilva, Jean N ^a,b  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

(r) 11c rolipram; Diet induced thermogenesis; High fat diet; Obesity; Positron emission tomography; Sympathetic nervous system, noradrenergic signaling

Indexed keywords

DESIPRAMINE; GLUCOSE; INSULIN; NORADRENALIN; PHOSPHODIESTERASE IV; ROLIPRAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CALORIMETRY; CONTROLLED STUDY; DRUG BINDING; ENERGY EXPENDITURE; IN VIVO STUDY; LIPID DIET; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WEIGHT GAIN;

ANIMALS; CALORIMETRY, INDIRECT; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DESIPRAMINE; DIETARY FATS; MALE; NOREPINEPHRINE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM;

EID: 65249157958     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-001     Document Type: Article

References (36)

1. Bachman, E.S., Dhillon, H., Zhang, C.Y., Cinti, S., Bianco, A.C., Kobilka, B.K., et al. 2002. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science, 297(5582): 843-845. doi:10.1126/science.1073160. PMID:12161655.
2. -/- and wild-type mice. Am. J. Physiol. Endocrinol. Metab. 281(5): E975-E982. PMID:11595653.
3. Bray, G.A., and York, D.A. 1979. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59(3): 719-809. PMID:379887.
4. Chang, S., Graham, B., Yakubu, F., Lin, D., Peters, J.C., and Hill, J.O. 1990. Metabolic differences between obesity-prone and obesity-resistant rats. Am. J. Physiol. 259(6 Pt 2): R1103-R1110. PMID:2260721.
5. Charon, C., Krief, S., Diot-Dupuy, F., Strosberg, A.D., Emorine, L.J., and Bazin, R. 1995. Early alterations in the brown adipose tissue adenylate cyclase system of pre-obese Zucker rat fa/fa pups: decreased G-proteins and beta 3-adrenoceptor activities. Biochem. J. 312(Pt 3): 781-788. PMID:8554520.
6. Collins, S., and Surwit, R.S. 2001. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog. Horm. Res. 56: 309-328. doi:10.1210/rp.56.1.309. PMID:11237219.
7. Corbett, S.W., Stern, J.S., and Keesey, R.E. 1986. Energy expenditure in rats with diet-induced obesity. Am. J. Clin. Nutr. 44(2): 173-180. PMID:3728354.
8. Coudray, C., Charon, C., Komas, N., Mory, G., Diot-Dupuy, F., Manganiello, V., et al. 1999. Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression. FEBS Lett. 456(1):207-210. doi:10.1016/S0014-5793(99) 00934-5. PMID:10452559.
9. 11C]rolipram. J. Labelled Comp. Radio-pharm. 44(5): 373-384. doi:10.1002/jlcr.465.
10. Dulloo, A.G. 2002. Biomedicine. A sympathetic defense against obesity. Science, 297(5582): 780-781. doi:10.1126/science. 1074923. PMID:12161638.
11. Elia, M., and Livesey, G. 1992. Energy expenditure and fuel selection in biological systems: the theory and practice of calcula-tions based on indirect calorimetry and tracer methods. World Rev. Nutr. Diet. 70: 68-131. PMID:1292242.
12. Engels, P., Fichtel, K., and Lübbert, H. 1994. Expression and regulation of human and rat phosphodiesterase type IV isogenes. FEBS Lett. 350: 291-295. doi:10.1016/0014-5793(94)00788-8. PMID:8070581.
13. Erickson, J.C., Hollopeter, G., and Palmiter, R.D. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science, 274(5293): 1704-1707. doi:10.1126/science. 274.5293.1704. PMID:8939859.
14. Gao, J., Ghibaudi, L., van Heek, M., and Hwa, J.J. 2002. Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Res. 936(1-2): 87-90. doi:10.1016/S0006-8993(02) 02493-9. PMID:11988234.
15. Himms-Hagen, J. 1997. On raising energy expenditure in ob/ob mice. Science, 276(5315): 1132-1133. doi:10.1126/science.276. 5315.1132. PMID:9173544.
16. Houslay, M.D., Sullivan, M., and Bolger, G.B. 1998. The multien-zyme PDE4 cyclic adenosine monophosphate-specific phospho-diesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Adv. Pharmacol. 44: 225-342. doi:10.1016/S1054-3589(08)60128-3. PMID:9547887.
17. Hughes, B., Owens, R., Perry, M., Warrellow, G., and Allen, R. 1997. PDE4 inhibitors: the use of molecular cloning in the design and development of novel drugs. Drug Discov. Today, 2: 89-101. doi:10.1016/S1359-6446(97)01000-3.
18. Johnson, R.W., Reisine, T., Spotnitz, S., Wiech, N., Ursillo, R., and Yamamura, H.I. 1980. Effects of desipramine and yohimbine on alpha 2-and beta-adrenoreceptor sensitivity. Eur. J. Pharmacol. 67(1): 123-127. doi:10.1016/0014-2999(80)90019-9. PMID:6252022.
19. Kannel, W.B., LeBauer, E.J., Dawber, T.R., and McNamara, P.M. 1967. Relation of body weight to development of coronary heart disease: the Framingham study. Circulation, 35(4): 734-744. PMID:6024013.
20. Kenk, M., Greene, M., Thackeray, J., Dekemp, R.A., Lortie, M., Thorn, S., et al. 2007. In vivo selective binding of (i?)-[nC]roli-pram to phosphodiesterase-4 provides the basis for studying in-tracellular cAMP signaling in the myocardium and other peripheral tissues. Nucl. Med. Biol. 34(1): 71-77. doi:10.1016/j. nucmedbio.2006.10.002. PMID:17210463.
21. Laliberte, F., Han, Y., Govindarajan, A., Giroux, A., Liu, S., Bo-bechko, B., et al. 2000. Conformational difference between PDE4 apoenzyme and holoenzyme. Biochemistry, 39(21):6449-6458. doi:10.1021/bi992432w. PMID:10828959.
22. Landsberg, L., Saville, M.E., and Young, J.B. 1984. Sympathoadre-nal system and regulation of thermogenesis. Am. J. Physiol. 247(2 Pt 1): E181-E189. PMID:6380306.
23. Levin, B.E., and Dunn-Meynell, A.A. 2000. Defense of body weight against chronic caloric restriction in obesity-prone and-resistant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278(1): R231-R237. PMID:10644644.
24. Levin, B.E., and Sullivan, A.C. 1989. Glucose-induced sympathetic activation in obesity-prone and resistant rats. Int. J. Obes. 13(2): 235-246. PMID:2744935.
25. Levin, B.E., Triscari, J., and Sullivan, A.C. 1983. Altered sympathetic activity during development of diet-induced obesity in rat. Am. J. Physiol. 244(3): R347-R355. PMID:6131610.
26. Lourenco, C.M., Houle, S., Wilson, A.A., and DaSilva, J.N. 2001. Characterization of (R)-[nC]rolipram for PET imaging of phos-phodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats. Nucl. Med. Biol. 28(4): 347-358. doi:10.1016/ S0969-8051(01)00206-2. PMID:11395307.
27. 11C]rolipram in rat brain, lung and heart. Life Sci. 79(4): 356-364. doi:10.1016/j.lfs.2006. 01.010. PMID:16499932.
28. Madelian, V., and La Vigne, E. 1996. Rapid regulation of a cyclic AMP-specific phosphodiesterase (PDE IV) by forskolin and iso-proterenol in LRM55 astroglial cells. Biochem. Pharmacol. 51: 1739-1747. doi:10.1016/0006-2952(96)00167-0. PMID:8687489.
29. Manning, C.D., McLaughlin, M.M., Livi, G.P., Cieslinski, L.B., Torphy, T.J., and Barnette, M.S. 1996. Prolonged beta adreno-ceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phos-phodiesterases 4A and 4B. J. Pharmacol. Exp. Ther. 276(2): 810-818. PMID:8632354.
30. Maskrey, M., Wiggins, P.R., and Frappell, P.B. 2001. Behavioral thermoregulation in obese and lean Zucker rats in a thermal gradient. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281(5): R1675-R1680. PMID:11641140.
31. Nagaoka, T., Shirakawa, T., Balon, T.W., Russell, J.C., and Fujita-Yamaguchi, Y. 1998. Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phos-phodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats. Diabetes, 47(7):1135-1144. doi:10.2337/diabetes. 47.7.1135. PMID:9648839.
32. Poirier, P., Giles, T.D., Bray, G.A., Hong, Y., Stern, J.S., Pi-Sunyer, F.X., et al. 2006. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation, 113(6): 898-918. doi:10.1161/ circulationaha.106.171016. PMID:16380542.
33. Raasmaja, A., and York, D.A. 1988. Alpha 1-and beta-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/ fa) Zucker rats: effects of cold-acclimation, sucrose feeding and adrenalectomy. Biochem. J. 249(3): 831-838. PMID:2895637.
34. Sette, C., and Conti, M. 1996. Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. J. Biol. Chem. 271: 16526-16534. doi:10.1074/jbc. 271.28.16526. PMID:8663227.
35. Sharma, A.M., Pischon, T., Hardt, S., Kunz, I., and Luft, F.C. 2001. Hypothesis: beta-adrenergic receptor blockers and weight gain: a systematic analysis. Hypertension, 37(2):250-254. PMID:11230280.
36. Tentolouris, N., Tsigos, C., Perea, D., Koukou, E., Kyriaki, D., Kit-sou, E., et al. 2003. Differential effects of high-fat and high-carbohydrate isoenergetic meals on cardiac autonomic nervous system activity in lean and obese women. Metabolism, 52(11): 1426-1432. doi:10.1016/S0026-0495(03) 00322-6. PMID:14624401.