Transglutaminase Cross-Links Sp1-Mediated Transcription to Ethanol-Induced Liver Injury

Gastroenterology

Volumn 136, Issue 5, 2009, Pages 1502-1505

  Strnad, Pavel ^a   Omary, M Bishr ^b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYTOKERATIN 8; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; CATALYSIS; CELL PROLIFERATION; CROSS LINKING; DNA BINDING; DOWN REGULATION; EDITORIAL; HUMAN; LIVER CELL; LIVER INJURY; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL;

EID: 65249140574     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.03.021     Document Type: Editorial

References (32)

1. Global status report on alcohol 2004. Available from: http://www.who.int/substance_abuse/publications/global_status_report_2004_overview.pdf.
2. Tsukamoto H. Conceptual importance of identifying alcoholic liver disease as a lifestyle disease. J Gastroenterol 42 (2007) 603-609
3. Diehl A.M., Chacon M., and Wagner P. The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration. Hepatology 8 (1988) 237-242
4. Diehl A.M., Abdo S., and Brown N. Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration. Hepatology 12 (1990) 633-637
5. McVicker B.L., Tuma D.J., and Casey C.A. Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells. World J Gastroenterol 13 (2007) 4960-4966
6. Tatsukawa H., Fukaya Y., Frampton G., et al. Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology 136 (2009) 1783-1795
7. Lorand L., and Graham R.M. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 4 (2003) 140-156
8. Esposito C., and Caputo I. Mammalian transglutaminases. Identification of substrates as a key to physiological function and physiopathological relevance. FEBS J 272 (2005) 615-631
9. Fesus L., and Piacentini M. Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci 27 (2002) 534-539
10. Elli L., Bergamini C.M., Bardella M.T., et al. Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver. Dig Liver Dis (2009) Feb 3 [Epub ahead of print]
11. Strnad P., Harada M., Siegel M., et al. Transglutaminase-2 regulates Mallory body inclusion formation and injury associated liver hypertrophy. Gastroenterology 132 (2007) 1515-1526
12. Mirza A., Liu S.L., Frizell E., et al. A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB. Am J Physiol 272 (1997) G281-G288
13. Grenard P., Bresson-Hadni S., El Alaoui S., et al. Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis. J Hepatol 35 (2001) 367-375
14. Nardacci R., Ciccosanti F., Falasca L., et al. Tissue transglutaminase in HCV infection. Cell Death Differ 10 (2003) S79-S80
15. Nardacci R., Lo Iacono O., Ciccosanti F., et al. Transglutaminase type II plays a protective role in hepatic injury. Am J Pathol 162 (2003) 1293-1303
16. Wu J., Liu S.L., Zhu J.L., et al. Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction. J Biol Chem 275 (2000) 22213-22219
17. Wu J., and Zern M.A. Tissue transglutaminase, a key enzyme involved in liver diseases. Hepatol Res 29 (2004) 1-8
18. Ku N.O., Strnad P., Zhong B.H., et al. Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology 46 (2007) 1639-1649
19. Huh C.G., Factor V.M., Sánchez A., et al. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101 (2004) 4477-4482
20. Seol D.W., and Zarnegar R. Structural and functional characterization of the mouse c-met proto-oncogene (hepatocyte growth factor receptor) promoter. Biochim Biophys Acta 1395 (1998) 252-258
21. Kim S.Y. Transglutaminase 2 in inflammation. Front Biosci 11 (2006) 3026-3035
22. Moon K.H., Abdelmegeed M.A., and Song B.J. Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver. FEBS Lett 581 (2007) 3967-3972
23. Wierstra I. Sp1: emerging roles-beyond constitutive activation of TATA-less housekeeping genes. Biochem Biophys Res Commun 372 (2008) 1-13
24. Marin M., Karis A., Visser P., et al. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 89 (1997) 619-628
25. Tomita K., Azuma T., Kitamura N., et al. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Gastroenterology 126 (2004) 873-885
26. Giebeler A., Boekschoten M.V., Klein C., et al. c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice. Gastroenterology (2009) Feb 4 [Epub ahead of print]
27. Rubio A., Guruceaga E., Vázquez-Chantada M., et al. Identification of a gene-pathway associated with non-alcoholic steatohepatitis. J Hepatol 46 (2007) 708-718
28. Moumen A., Ieraci A., Patané S., et al. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner. Hepatology 45 (2007) 1210-1217
29. Fésüs L., and Szondy Z. Transglutaminase 2 in the balance of cell death and survival. FEBS Lett 579 (2005) 3297-3302
30. Sarang Z., Molnár P., Németh T., et al. Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice. Hepatology 42 (2005) 578-587
31. Nanji A.A., Jokelainen K., Rahemtulla A., et al. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 30 (1999) 934-943
32. Román J., Giménez A., Lluis J.M., et al. Enhanced DNA binding and activation of transcription factors NF-kappa B and AP-1 by acetaldehyde in HEPG2 cells. J Biol Chem 275 (2000) 14684-14690