-
2
-
-
33644818304
-
1026 Experimental treatments in acute stroke
-
O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1026 Experimental treatments in acute stroke. Ann Neurol. 2006;59:467-477.
-
(2006)
Ann Neurol
, vol.59
, pp. 467-477
-
-
O'Collins, V.E.1
Macleod, M.R.2
Donnan, G.A.3
Horky, L.L.4
van der Worp, B.H.5
Howells, D.W.6
-
3
-
-
0036709869
-
Structure to function relationships in ceruloplasmin: A 'moonlighting' protein
-
Bielli P, Calabrese L. Structure to function relationships in ceruloplasmin: a 'moonlighting' protein. Cell Mol Life Sci. 2002;59:1413-1427.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 1413-1427
-
-
Bielli, P.1
Calabrese, L.2
-
4
-
-
0028267292
-
Intact human ceruloplasmin oxida-tively modifies low density lipoprotein
-
Ehrenwald E, Chisolm GM, Fox PL. Intact human ceruloplasmin oxida-tively modifies low density lipoprotein. J Clin Invest. 1994;93: 1493-1501.
-
(1994)
J Clin Invest
, vol.93
, pp. 1493-1501
-
-
Ehrenwald, E.1
Chisolm, G.M.2
Fox, P.L.3
-
5
-
-
0030851818
-
Identification of the prooxidant site of human ceruloplasmin: A model for oxidative damage by copper bound to protein surfaces
-
Mukhopadhyay CK, Mazumder B, Lindley PF, Fox PL. Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfaces. Proc Natl Acad Sci U S A. 1997;94:11546-11551.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 11546-11551
-
-
Mukhopadhyay, C.K.1
Mazumder, B.2
Lindley, P.F.3
Fox, P.L.4
-
6
-
-
33646186045
-
Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?
-
Shukla N, Maher J, Masters J, Angelini GD, Jeremy JY. Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor? Atherosclerosis. 2006;187:238-250.
-
(2006)
Atherosclerosis
, vol.187
, pp. 238-250
-
-
Shukla, N.1
Maher, J.2
Masters, J.3
Angelini, G.D.4
Jeremy, J.Y.5
-
7
-
-
0037024226
-
Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men
-
Engstrom G, Lind P, Hedblad B, Stavenow L, Janzon L, Lindgarde F. Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men. Circulation. 2002; 105:2632-2637.
-
(2002)
Circulation
, vol.105
, pp. 2632-2637
-
-
Engstrom, G.1
Lind, P.2
Hedblad, B.3
Stavenow, L.4
Janzon, L.5
Lindgarde, F.6
-
8
-
-
33748967907
-
Inflammatory markers and in-hospital mortality in acute ischaemic stroke
-
Rallidis LS, Vikelis M, Panagiotakos DB, Rizos I, Zolindaki MG, Kaliva K, Kremastinos DT. Inflammatory markers and in-hospital mortality in acute ischaemic stroke. Atherosclerosis. 2006;189:193-197.
-
(2006)
Atherosclerosis
, vol.189
, pp. 193-197
-
-
Rallidis, L.S.1
Vikelis, M.2
Panagiotakos, D.B.3
Rizos, I.4
Zolindaki, M.G.5
Kaliva, K.6
Kremastinos, D.T.7
-
9
-
-
33751225029
-
Variability of the systemic acute phase response after ischemic stroke
-
Smith CJ, Emsley HC, Vail A, Georgiou RF, Rothwell NJ, Tyrrell PJ, Hopkins SJ. Variability of the systemic acute phase response after ischemic stroke. J Neurol Sci. 2006;251:77-81.
-
(2006)
J Neurol Sci
, vol.251
, pp. 77-81
-
-
Smith, C.J.1
Emsley, H.C.2
Vail, A.3
Georgiou, R.F.4
Rothwell, N.J.5
Tyrrell, P.J.6
Hopkins, S.J.7
-
10
-
-
33947127602
-
Acute phase proteins and oxidised low-density lipoprotein in association with ischemic stroke subtype, severity and outcome
-
Vibo R, Korv J, Roose M, Kampus P, Muda P, Zilmer K, Zilmer M. Acute phase proteins and oxidised low-density lipoprotein in association with ischemic stroke subtype, severity and outcome. Free Radic Res. 2007;41:282-287.
-
(2007)
Free Radic Res
, vol.41
, pp. 282-287
-
-
Vibo, R.1
Korv, J.2
Roose, M.3
Kampus, P.4
Muda, P.5
Zilmer, K.6
Zilmer, M.7
-
11
-
-
0032910250
-
Serum caeruloplasmin as a coronary risk factor in the elderly: The Rotterdam Study
-
Klipstein-Grobusch K, Grobbee DE, Koster JF, Lindemans J, Boeing H, Hofman A, Witteman JC. Serum caeruloplasmin as a coronary risk factor in the elderly: the Rotterdam Study. Br J Nutr. 1999;81:139-144.
-
(1999)
Br J Nutr
, vol.81
, pp. 139-144
-
-
Klipstein-Grobusch, K.1
Grobbee, D.E.2
Koster, J.F.3
Lindemans, J.4
Boeing, H.5
Hofman, A.6
Witteman, J.C.7
-
12
-
-
0035477031
-
A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: Roles of lipid hydroperoxides, alpha-tocopherol, thiols, and ceruloplasmin
-
Burkitt MJ. A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: roles of lipid hydroperoxides, alpha-tocopherol, thiols, and ceruloplasmin. Arch Biochem Biophys. 2001;394: 117-135.
-
(2001)
Arch Biochem Biophys
, vol.394
, pp. 117-135
-
-
Burkitt, M.J.1
-
13
-
-
0035824113
-
Oxidative modification of human ceruloplasmin by peroxyl radicals
-
Kang JH, Kim KS, Choi SY, Kwon HY, Won MH. Oxidative modification of human ceruloplasmin by peroxyl radicals. Biochim Biophys Acta. 2001;1568:30-36.
-
(2001)
Biochim Biophys Acta
, vol.1568
, pp. 30-36
-
-
Kang, J.H.1
Kim, K.S.2
Choi, S.Y.3
Kwon, H.Y.4
Won, M.H.5
-
15
-
-
0028085998
-
Iron-related damage in acute ischemic stroke
-
Davalos A, Fernandez-Real JM, Ricart W, Soler S, Molins A, Planas E, Genis D. Iron-related damage in acute ischemic stroke. Stroke. 1994;25: 1543-1546.
-
(1994)
Stroke
, vol.25
, pp. 1543-1546
-
-
Davalos, A.1
Fernandez-Real, J.M.2
Ricart, W.3
Soler, S.4
Molins, A.5
Planas, E.6
Genis, D.7
-
16
-
-
0343134573
-
Body iron stores and early neurologic deterioration in acute cerebral infarction
-
Davalos A, Castillo J, Marrugat J, Fernandez-Real JM, Armengou A, Cacabelos P, Rama R. Body iron stores and early neurologic deterioration in acute cerebral infarction. Neurology. 2000;54:1568-1574.
-
(2000)
Neurology
, vol.54
, pp. 1568-1574
-
-
Davalos, A.1
Castillo, J.2
Marrugat, J.3
Fernandez-Real, J.M.4
Armengou, A.5
Cacabelos, P.6
Rama, R.7
-
17
-
-
0036836133
-
Serum ferritin levels and early prognosis of stroke
-
Erdemoglu AK, Ozbakir S. Serum ferritin levels and early prognosis of stroke. Eur J Neurol. 2002;9:633-637.
-
(2002)
Eur J Neurol
, vol.9
, pp. 633-637
-
-
Erdemoglu, A.K.1
Ozbakir, S.2
-
18
-
-
67649307592
-
-
Stroke Prevention and Educational Awareness Diffusion (SPREAD) collaboration. Italian Guidelines for Stroke Prevention and Management. IV Edition. Hyperphar Group SpA, 2005.
-
Stroke Prevention and Educational Awareness Diffusion (SPREAD) collaboration. Italian Guidelines for Stroke Prevention and Management. IV Edition. Hyperphar Group SpA, 2005.
-
-
-
-
19
-
-
20144371701
-
Excess of serum copper not related to ceruloplasmin in Alzheimer disease
-
Squitti R, Pasqualetti P, Dal Forno G, Moffa F, Cassetta E, Lupoi D, Vernieri F, Rossi L, Baldassini M, Rossini PM. Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology. 2005;64: 1040-1046.
-
(2005)
Neurology
, vol.64
, pp. 1040-1046
-
-
Squitti, R.1
Pasqualetti, P.2
Dal Forno, G.3
Moffa, F.4
Cassetta, E.5
Lupoi, D.6
Vernieri, F.7
Rossi, L.8
Baldassini, M.9
Rossini, P.M.10
-
20
-
-
41749102147
-
Quantification of atheromatous stenosis in the extracranial internal carotid artery
-
De Bray JM, Glatt B. Quantification of atheromatous stenosis in the extracranial internal carotid artery. Cerebrovasc Dis. 1995;5:414-426.
-
(1995)
Cerebrovasc Dis
, vol.5
, pp. 414-426
-
-
De Bray, J.M.1
Glatt, B.2
-
21
-
-
34249822830
-
What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia?
-
Altamura C, Squitti R, Pasqualetti P, Tibuzzi F, Silvestrini M, Ventriglia MC, Cassetta E, Rossini PM, Vernieri F. What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia? Eur J Neurol. 2007; 14:679-682.
-
(2007)
Eur J Neurol
, vol.14
, pp. 679-682
-
-
Altamura, C.1
Squitti, R.2
Pasqualetti, P.3
Tibuzzi, F.4
Silvestrini, M.5
Ventriglia, M.C.6
Cassetta, E.7
Rossini, P.M.8
Vernieri, F.9
-
22
-
-
33846269659
-
Mannheim carotid intima-media thickness consensus (2004-2006)
-
Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Jaff M, Kownator S, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M. Mannheim carotid intima-media thickness consensus (2004-2006). Cerebrovasc Dis. 2007; 23:75-80.
-
(2007)
Cerebrovasc Dis
, vol.23
, pp. 75-80
-
-
Touboul, P.J.1
Hennerici, M.G.2
Meairs, S.3
Adams, H.4
Amarenco, P.5
Bornstein, N.6
Csiba, L.7
Desvarieux, M.8
Ebrahim, S.9
Fatar, M.10
Hernandez Hernandez, R.11
Jaff, M.12
Kownator, S.13
Prati, P.14
Rundek, T.15
Sitzer, M.16
Schminke, U.17
Tardif, J.C.18
Taylor, A.19
Vicaut, E.20
Woo, K.S.21
Zannad, F.22
Zureik, M.23
more..
-
23
-
-
0037003044
-
d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients
-
Squitti R, Rossini PM, Cassetta E, Moffa F, Pasqualetti P, Cortesi M, Colloca A, Rossi L, Finazzi-Agró A. d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients. Eur J Clin Invest. 2002; 32:51-59.
-
(2002)
Eur J Clin Invest
, vol.32
, pp. 51-59
-
-
Squitti, R.1
Rossini, P.M.2
Cassetta, E.3
Moffa, F.4
Pasqualetti, P.5
Cortesi, M.6
Colloca, A.7
Rossi, L.8
Finazzi-Agró, A.9
-
24
-
-
0024558099
-
Sensitive, direct colorimetric assay for copper in serum
-
Abe A, Yamashita S, Noma A. Sensitive, direct colorimetric assay for copper in serum. Clin Chem. 1989;35:552-554.
-
(1989)
Clin Chem
, vol.35
, pp. 552-554
-
-
Abe, A.1
Yamashita, S.2
Noma, A.3
-
25
-
-
0000937035
-
The radical cation of N, N-Diethyl-para-phenylendiamine:a possible indicator of oxidative stress in biochemical samples
-
Alberti A, Bolognini L, Macciantelli D, Carratelli M. The radical cation of N, N-Diethyl-para-phenylendiamine:a possible indicator of oxidative stress in biochemical samples. Res Chem Intermed. 2000;26:253-267.
-
(2000)
Res Chem Intermed
, vol.26
, pp. 253-267
-
-
Alberti, A.1
Bolognini, L.2
Macciantelli, D.3
Carratelli, M.4
-
26
-
-
0028116941
-
Total antioxidant status in plasma and body fluids
-
Rice-Evans C, Miller NJ. Total antioxidant status in plasma and body fluids. Methods Enzymol. 1994;234:279-293.
-
(1994)
Methods Enzymol
, vol.234
, pp. 279-293
-
-
Rice-Evans, C.1
Miller, N.J.2
-
27
-
-
0020006080
-
Ceruloplasmin: Methods and clinical use
-
Wolf PL. Ceruloplasmin: methods and clinical use. Crit Rev Clin Lab Sci. 1982;17:229-245.
-
(1982)
Crit Rev Clin Lab Sci
, vol.17
, pp. 229-245
-
-
Wolf, P.L.1
-
28
-
-
0025271562
-
Serum transferrin receptor, a quantitative measure of tissue iron deficiency
-
Skikne BS, Flowers CH, Cole JD. Serum transferrin receptor, a quantitative measure of tissue iron deficiency. Blood. 1990;75:1870-1876.
-
(1990)
Blood
, vol.75
, pp. 1870-1876
-
-
Skikne, B.S.1
Flowers, C.H.2
Cole, J.D.3
-
29
-
-
0019609479
-
Novel chromogen for serum iron determinations
-
Higgins T. Novel chromogen for serum iron determinations. Clin Chem. 1981;27:1619-1620.
-
(1981)
Clin Chem
, vol.27
, pp. 1619-1620
-
-
Higgins, T.1
-
30
-
-
0037350153
-
Wilson's disease: The importance of measuring serum cae-ruloplasmin non-immunologically
-
Walshe JM. Wilson's disease: the importance of measuring serum cae-ruloplasmin non-immunologically. Ann Clin Biochem. 2003;40:115-121.
-
(2003)
Ann Clin Biochem
, vol.40
, pp. 115-121
-
-
Walshe, J.M.1
-
31
-
-
0030474271
-
A simulation study of the number of events per variable in logistic regression analysis
-
Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373-1379.
-
(1996)
J Clin Epidemiol
, vol.49
, pp. 1373-1379
-
-
Peduzzi, P.1
Concato, J.2
Kemper, E.3
Holford, T.R.4
Feinstein, A.R.5
-
32
-
-
0021696618
-
The antioxidant system of transferrin-ceruloplasmin in experimental hypercholes-terolemia
-
Kozlov AV, Sergienko VI, Vladimirov Iu A, Azizova OA. The antioxidant system of transferrin-ceruloplasmin in experimental hypercholes-terolemia. Biull Eksp Biol Med. 1984;98:668-671.
-
(1984)
Biull Eksp Biol Med
, vol.98
, pp. 668-671
-
-
Kozlov, A.V.1
Sergienko, V.I.2
Vladimirov, I.A.3
Azizova, O.A.4
-
33
-
-
1642371463
-
Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury
-
de Vries B, Walter SJ, von Bonsdorff L, Wolfs TG, van Heurn LW, Parkkinen J, Buurman WA. Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury. Transplantation. 2004;77:669-675.
-
(2004)
Transplantation
, vol.77
, pp. 669-675
-
-
de Vries, B.1
Walter, S.J.2
von Bonsdorff, L.3
Wolfs, T.G.4
van Heurn, L.W.5
Parkkinen, J.6
Buurman, W.A.7
-
34
-
-
0043204506
-
A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS)
-
RANTTAS Investigators
-
RANTTAS Investigators. A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). Stroke. 1996;27:1453-1458.
-
(1996)
Stroke
, vol.27
, pp. 1453-1458
-
-
-
35
-
-
0031781078
-
High-dose tirilazad for acute stroke (RANTTAS II)
-
Haley E. High-dose tirilazad for acute stroke (RANTTAS II). Stroke. 1998;29:1256-1257.
-
(1998)
Stroke
, vol.29
, pp. 1256-1257
-
-
Haley, E.1
-
36
-
-
0031876380
-
Effect of reactive oxygen species on iron regulatory protein activity
-
Cairo G, Tacchini L, Recalcati S, Azzimonti B, Minotti G, Bernelli-Zazzera A. Effect of reactive oxygen species on iron regulatory protein activity. Ann N Y Acad Sci. 1998;851:179-186.
-
(1998)
Ann N Y Acad Sci
, vol.851
, pp. 179-186
-
-
Cairo, G.1
Tacchini, L.2
Recalcati, S.3
Azzimonti, B.4
Minotti, G.5
Bernelli-Zazzera, A.6
-
37
-
-
0000655498
-
Identification of a hypoxia response element in the transferrin receptor gene
-
Lok CN, Ponka P. Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem. 1999;274:24147-24152.
-
(1999)
J Biol Chem
, vol.274
, pp. 24147-24152
-
-
Lok, C.N.1
Ponka, P.2
-
38
-
-
20444412608
-
Copper-dependent activation of hypoxia-inducible factor (HIF)-l: Implications for ceruloplasmin regulation
-
Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukho-padhyay CK, Eckhardt K, Troger J, Barth S, Camenisch G, Wenger RH. Copper-dependent activation of hypoxia-inducible factor (HIF)-l: implications for ceruloplasmin regulation. Blood. 2005;105:4613-4619.
-
(2005)
Blood
, vol.105
, pp. 4613-4619
-
-
Martin, F.1
Linden, T.2
Katschinski, D.M.3
Oehme, F.4
Flamme, I.5
Mukho-padhyay, C.K.6
Eckhardt, K.7
Troger, J.8
Barth, S.9
Camenisch, G.10
Wenger, R.H.11
-
39
-
-
0036703490
-
Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury
-
Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci. 2002;22:6578-6586.
-
(2002)
J Neurosci
, vol.22
, pp. 6578-6586
-
-
Patel, B.N.1
Dunn, R.J.2
Jeong, S.Y.3
Zhu, Q.4
Julien, J.P.5
David, S.6
-
40
-
-
33747602092
-
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
-
Shiva S, Wang X, Ringwood LA, Xu X, Yuditskaya S, Annavajjhala V, Miyajima H, Hogg N, Harris ZL, Gladwin MT. Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. Nat Chem Biol. 2006;2:486-493.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 486-493
-
-
Shiva, S.1
Wang, X.2
Ringwood, L.A.3
Xu, X.4
Yuditskaya, S.5
Annavajjhala, V.6
Miyajima, H.7
Hogg, N.8
Harris, Z.L.9
Gladwin, M.T.10
-
41
-
-
0034984521
-
Rethinking the role of ceruloplasmin in brain iron metabolism
-
Qian ZM, Ke Y. Rethinking the role of ceruloplasmin in brain iron metabolism. Brain Res Brain Res Rev. 2001;35:287-294.
-
(2001)
Brain Res Brain Res Rev
, vol.35
, pp. 287-294
-
-
Qian, Z.M.1
Ke, Y.2
-
42
-
-
0242415177
-
Role of ceruloplasmin in macrophage iron efflux during hypoxia
-
Sarkar J, Seshadri V, Tripoulas NA, Ketterer ME, Fox PL. Role of ceruloplasmin in macrophage iron efflux during hypoxia. J Biol Chem. 2003;278:44018-44024.
-
(2003)
J Biol Chem
, vol.278
, pp. 44018-44024
-
-
Sarkar, J.1
Seshadri, V.2
Tripoulas, N.A.3
Ketterer, M.E.4
Fox, P.L.5
-
43
-
-
0141641093
-
Antioxidant potential and transferrin, ceruloplasmin, and lipid peroxidation levels in women with preeclampsia
-
Aksoy H, Taysi S, Altinkaynak K, Bakan E, Bakan N, Kumtepe Y. Antioxidant potential and transferrin, ceruloplasmin, and lipid peroxidation levels in women with preeclampsia. J Investig Med. 2003;51: 284-287.
-
(2003)
J Investig Med
, vol.51
, pp. 284-287
-
-
Aksoy, H.1
Taysi, S.2
Altinkaynak, K.3
Bakan, E.4
Bakan, N.5
Kumtepe, Y.6
-
44
-
-
33646797408
-
Serum iron and copper status and oxidative stress in severe and mild preeclampsia
-
Serdar Z, Gtir E, Develioǧlu O. Serum iron and copper status and oxidative stress in severe and mild preeclampsia. Cell Biochem Funct. 2006;24:209-215.
-
(2006)
Cell Biochem Funct
, vol.24
, pp. 209-215
-
-
Serdar, Z.1
Gtir, E.2
Develioǧlu, O.3
-
45
-
-
0022973587
-
Transcriptional regulation of plasma protein synthesis during inflammation
-
Birch HE, Schreiber G. Transcriptional regulation of plasma protein synthesis during inflammation. J Biol Chem. 1986;261:8077-8080.
-
(1986)
J Biol Chem
, vol.261
, pp. 8077-8080
-
-
Birch, H.E.1
Schreiber, G.2
-
46
-
-
0035157347
-
Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke
-
Di Napoli M, Papa F, Bocola V. Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke. Stroke. 2001; 32:133-138.
-
(2001)
Stroke
, vol.32
, pp. 133-138
-
-
Di Napoli, M.1
Papa, F.2
Bocola, V.3
-
47
-
-
0036792815
-
Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke
-
Winbeck K, Poppert H, Etgen T, Conrad B, Sander D. Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke. Stroke. 2002;33:2459-2464.
-
(2002)
Stroke
, vol.33
, pp. 2459-2464
-
-
Winbeck, K.1
Poppert, H.2
Etgen, T.3
Conrad, B.4
Sander, D.5
-
48
-
-
33846590017
-
Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia
-
Nagaraja TN, Keenan KA, Brown SL, Fenstermacher JD, Knight RA. Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia. Neurol Res. 2007;29:78-80.
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(2007)
Neurol Res
, vol.29
, pp. 78-80
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Nagaraja, T.N.1
Keenan, K.A.2
Brown, S.L.3
Fenstermacher, J.D.4
Knight, R.A.5
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