Parenteral water/oil emulsions containing hydrophilic compounds with enhanced in vivo retention: Formulation, rheological characterisation and study of in vivo fate using whole body gamma-scintigraphy

International Journal of Pharmaceutics

Volumn 215, Issue 1-2, 2001, Pages 13-27

  Bjerregaard, Simon ^a   Pedersen, Heidi ^c   Vedstesen, Helle ^c   Vermehren, Charlotte ^a   Söderberg, Ingrid ^b   Frokjaer, Sven ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c DANISH MEDICINES AGENCY   (Denmark)

Author keywords

Disappearance rates; Intramuscular administration; Rheology; Spreading mechanism; Sustained release; W o emulsions

Indexed keywords

APROTININ; INTRALIPID; PERTECHNETIC ACID TC 99M; WATER;

ARTICLE; DRUG BIOAVAILABILITY; DRUG FORMULATION; EMULSION; FIRST PASS EFFECT; FLOW KINETICS; GAMMA SCINTIGRAPHY; HYDROPHILICITY; INJECTION SITE; MUSCLE; PLASMA HALF LIFE; PRIORITY JOURNAL; RABBIT; SUSTAINED RELEASE PREPARATION; THIGH; VISCOELASTICITY;

ALGORITHMS; ANIMALS; APROTININ; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EMULSIONS; FEMALE; INJECTIONS, INTRAMUSCULAR; OILS; RABBITS; RHEOLOGY; SERINE PROTEINASE INHIBITORS; SURFACE PROPERTIES; TECHNETIUM COMPOUNDS; TISSUE DISTRIBUTION; WATER; WHOLE-BODY COUNTING;

EID: 0035857707     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00656-6     Document Type: Article

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