A new approach to four- and five-component Ugi condensations starting from nitriles

Tetrahedron Letters

Volumn 47, Issue 7, 2006, Pages 1205-1207

  Simoneau, Christopher A ^a   George, Elizabeth A ^a   Ganem, Bruce ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRILE; ORGANOMETALLIC COMPOUND;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; POLYMERIZATION;

EID: 30544450007     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.12.011     Document Type: Article

References (14)

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4. Q. Xia, and B. Ganem Org. Lett. 4 2002 1631
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6. B.J. Wakefield G. Wilkinson Comprehensive Organometallic Chemistry 1982 Pergamon Press Chapter 44
7. L. Banfi, A. Basso, G. Guanti, and R. Riva Tetrahedron Lett. 44 2003 7655
8. P. Canonne, G.B. Foscolos, and L. Gilles Tetrahedron Lett. 21 1980 155
9. Organolithiums: G. Sumrell J. Org. Chem. 19 1954 817
10. Grignard reagents: C.H. Hauser, and W.J. Humplett J. Org. Chem. 15 1950 359
11. I. Ugi Intra-Sci. Chem. Reports 5 1971 229
12. S. Marcaccini, D. Miguel, T. Torruba, and M. Garcia-Valverde J. Org. Chem. 68 2003 3315
13. 4, filtered and concentrated in vacuo to an oil, which was purified via silica gel flash column chromatography.
14. 3OH was removed in vacuo and the reaction worked up as described for the 4CC process (Ref. 10).