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This study provides evidence that the activation of endogenous self-reactive T cells is unlikely to result in major autoimmune pathology upon TCR gene transfer.
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Weinhold M., Sommermeyer D., Uckert W., and Blankenstein T. Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity. J Immunol 179 (2007) 5534-5542. This study provides evidence that the activation of endogenous self-reactive T cells is unlikely to result in major autoimmune pathology upon TCR gene transfer.
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Weinhold, M.1
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Facilitating matched pairing and expression of TCR chains introduced into human T cells
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Study describing the use of an engineered disulfide to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Kuball J., Dossett M.L., Wolfl M., Ho W.Y., Voss R.H., Fowler C., and Greenberg P.D. Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood 109 (2007) 2331-2338. Study describing the use of an engineered disulfide to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Blood
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Kuball, J.1
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Ho, W.Y.4
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Fowler, C.6
Greenberg, P.D.7
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40
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Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond
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Study describing the use of an engineered disulfide to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Cohen C.J., Li Y.F., El-Gamil M., Robbins P.F., Rosenberg S.A., and Morgan R.A. Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond. Cancer Res 67 (2007) 3898-3903. Study describing the use of an engineered disulfide to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Cancer Res
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Cohen, C.J.1
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Morgan, R.A.6
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41
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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability
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Study describing the use of murine constant domains to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Cohen C.J., Zhao Y., Zheng Z., Rosenberg S.A., and Morgan R.A. Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res 66 (2006) 8878-8886. Study describing the use of murine constant domains to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Cancer Res
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Cohen, C.J.1
Zhao, Y.2
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Morgan, R.A.5
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42
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Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells
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Study describing a TCR engineering strategy that may be utilized to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Voss R.H., Willemsen R.A., Kuball J., Grabowski M., Engel R., Intan R.S., Guillaume P., Romero P., Huber C., and Theobald M. Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells. J Immunol 180 (2008) 391-401. Study describing a TCR engineering strategy that may be utilized to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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J Immunol
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Voss, R.H.1
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Kuball, J.3
Grabowski, M.4
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Intan, R.S.6
Guillaume, P.7
Romero, P.8
Huber, C.9
Theobald, M.10
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43
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Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer
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Study describing the use of TCR fusion receptors to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Sebestyen Z., Schooten E., Sals T., Zaldivar I., San Jose E., Alarcon B., Bobisse S., Rosato A., Szollosi J., Gratama J.W., et al. Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer. J Immunol 180 (2008) 7736-7746. Study describing the use of TCR fusion receptors to limit the formation of auto-aggressive mixed TCR dimers, of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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Sebestyen, Z.1
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Bobisse, S.7
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Gratama, J.W.10
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44
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Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer
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Heemskerk M.H., Hoogeboom M., Hagedoorn R., Kester M.G., Willemze R., and Falkenburg J.H. Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer. J Exp Med 199 (2004) 885-894
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Falkenburg, J.H.6
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45
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Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR
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Willemsen R.A., Weijtens M.E., Ronteltap C., Eshhar Z., Gratama J.W., Chames P., and Bolhuis R.L. Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR. Gene Ther 7 (2000) 1369-1377
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Zhang T., He X., Tsang T.C., and Harris D.T. Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther 11 (2004) 487-496
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47
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Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity
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Study describing the use of gamma-delta T cells as recipient T cells to limit the formation of auto-aggressive mixed TCR dimers. Together with earlier work from this group based on the use of polyclonal T cell populations, this work is of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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van der Veken L.T., Hagedoorn R.S., van Loenen M.M., Willemze R., Falkenburg J.H., and Heemskerk M.H. Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity. Cancer Res 66 (2006) 3331-3337. Study describing the use of gamma-delta T cells as recipient T cells to limit the formation of auto-aggressive mixed TCR dimers. Together with earlier work from this group based on the use of polyclonal T cell populations, this work is of particular relevance in view of increasing concerns regarding mixed TCR dimer-mediated toxicity.
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van der Veken, L.T.1
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Falkenburg, J.H.5
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αβ T cell receptor transfer to γδ T cells generates functional effector cells without mixed TCR dimers in vivo
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van der Veken L.T., Coccoris M., Swart E., Falkenburg J.H.F., Schumacher T.N., and Heemskerk M.H.M. αβ T cell receptor transfer to γδ T cells generates functional effector cells without mixed TCR dimers in vivo. J Immunol 182 (2009) 164-170
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van der Veken, L.T.1
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A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
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Kieback E., Charo J., Sommermeyer D., Blankenstein T., and Uckert W. A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer. Proc Natl Acad Sci U S A 105 (2008) 623-628
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de Witte M.A., Jorritsma A., Swart E., Straathof K.C., de Punder K., Haanen J.B., Rooney C.M., and Schumacher T.N. An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease. J Immunol 180 (2008) 6365-6373
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Offringa R. Antigen choice in adoptive T-cell therapy of cancer. Curr Opin Immunol 21 (2009) 190-199
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