A flexible and high throughput liquid chromatography-tandem mass spectrometric assay for the quantitation of telcagepant in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 14-15, 2009, Pages 1465-1471

  Du, Lihong ^a   Miller Stein, Cynthia M ^a   Valesky, Robert J ^a   Martucci, Ashley N ^a   Woolf, Eric J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Human plasma; LC MS MS; Protein precipitation; Telcagepant (MK 0974)

Indexed keywords

96 WELLS; ATMOSPHERIC PRESSURE CHEMICAL IONIZATIONS; CALCITONIN GENE-RELATED PEPTIDES; CALIBRATION CURVES; CALIBRATION STANDARDS; CLINICAL DEVELOPMENT; CLINICAL SAMPLES; CLINICAL TRIALS; COEFFICIENT OF VARIATIONS; DIASTEREOMER; HIGH THROUGHPUTS; HUMAN CONTROLS; HUMAN PLASMA; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LC-MS/MS; LINEAR CALIBRATIONS; LIQUID HANDLINGS; PROTEIN PRECIPITATION; RECEPTOR ANTAGONISTS; SAMPLE PROCESSING; TANDEM MASS SPECTROMETRIC; TANDEM MASS SPECTROMETRIES; TELCAGEPANT (MK-0974);

ACETONITRILE; AMINES; ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BODY FLUIDS; CALIBRATION; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC ACIDS; PLASMA (HUMAN); PLASMAS; PRECIPITATION (CHEMICAL); THROUGHPUT;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ACETONITRILE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; FORMIC ACID; MK 0974; TELCAGEPANT; UNCLASSIFIED DRUG; WATER;

ARTICLE; CALIBRATION; DIAGNOSTIC ACCURACY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MIGRAINE; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY;

AZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMIDAZOLES; MIGRAINE DISORDERS; TANDEM MASS SPECTROMETRY;

EID: 65249095338     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.03.019     Document Type: Article

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