Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 1, 2008, Pages 64-73

  Xu, Yang ^a   Willson, Kenneth J ^a   Musson, Donald G ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BIOMARIN PHARMACEUTICAL INC   (United States)

Author keywords

CGRP receptor antagonist; Cohesive technology; High turbulence liquid chromatograph (HTLC); MK 0974; On line extraction; Parallel validation

Indexed keywords

CGRP RECEPTOR ANTAGONIST; COHESIVE TECHNOLOGY; HIGH-TURBULENCE LIQUID CHROMATOGRAPH (HTLC); ON-LINE EXTRACTION;

EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); TURBULENT FLOW;

BIOASSAY;

BOVINE SERUM ALBUMIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; MK 0974; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; CONTAINER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; DYNAMICS; ELUTION; EXTRACTION; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INJECTION; IONIZATION; LIQUID; MONITORING; ONLINE ANALYSIS; PLASMA; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; ROOM TEMPERATURE; SAMPLE; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; TIME; TURBULENT FLOW; URINALYSIS; URINE; VALIDATION STUDY;

AZEPINES; CHROMATOGRAPHY, THIN LAYER; HUMANS; IMIDAZOLES; INDICATORS AND REAGENTS; ONLINE SYSTEMS; QUALITY CONTROL; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY;

EID: 39149139304     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.12.017     Document Type: Article

References (20)

1. Olesen J., Diener H., Husstedt I.W., Goadsby P.J., Hall D., Meier U., Pollentier S., and Lesko L.M. N. Engl. J. Med. 350 (2004) 1104
2. Wu D., Doods H., Arndt K., and Schindler M. Biochem. Soc. Trans. 30 (2002) 468
3. Durham P.L. N. Engl. J. Med. 350 (2004) 1073
4. Doggrell S.A. Exp. Opin. Investig. Drugs 10 (2001) 1131
5. C.S. Burgey, Z.J. Deng, D.N. Ngugen, D.V. Paone, A.W. Shaw, T.M. Williams, US Patent 6,953,790, The United State Patent and Trademark Office (USPTO), October 11, 2005.
6. Ho T.W., Mannix L.K., Fan X., Assaid C., Furtek C., Jones C.J., Lines C.R., and Rapoport A.M. Neurology October (3) (2007) (Epub ahead of print)
7. Ayrton J., Dear D.J., Leavens W.J., Mallett D.N., and Plumb R.S. Rapid Commun. Mass Spectrom. 11 (1997) 1953
8. Brignol N., Bakhtiar R., Dou L., Majumdar T., and Tse F.L.S. Rapid Commun. Mass Spectrom. 14 (2000) 14
9. Ramos L., Brignol N., Bakhtiar R., Ray T., McMahon L.M., and Tse F.L.S. Rapid Commun. Mass Spectrom. 14 (2000) 2282
10. Cass R.T., Villa J.S., Karr D.E., and Schmidt Jr. D.E. Rapid Commun. Mass Spectrom. 15 (2001) 406
11. Takino M., Daishina S., Yamaguchi K., and Nakahara T. Analyst 128 (2003) 46
12. Herman J.L. Rapid Commun. Mass Spectrom. 16 (2002) 421
13. Zeng W., Wang A.Q., Fisher A.L., and Mussion D.G. Rapid Commun. Mass Spectrom. 17 (2003) 2475
14. Xu X., Yan K.X., Song H., and Lo M.W. J. Chromatogr. B 814 (2005) 29
15. Zeng W., Mussion D.G., Fisher A.L., and Wang A.Q. Rapid Commun. Mass Spectrom. 20 (2006) 1169
16. Schwartz M., Kline W., and Matuszewski B. Anal. Chim. Acta 352 (1997) 299
17. Fisher A.L., DePuy E., Shih T., Stearns R., Lee Y., Gottesdiener K., Flattery S., Smet M.D., Keymeulen B., and Musson D.G. J. Pharm. Biomed. Anal. 26 (2001) 739
18. Xu Y., Du L., Rose M.J., Fu I., Woolf E.J., and Musson D.G. J. Chromatogr. B 818 (2005) 241
19. Zeng W., Mussion D.G., Fisher A.L., and Wang A.Q. J. Chromatogr. B 806 (2004) 177
20. Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation, US Department of Health and Human Servises, May 2001.