Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 873, Issue 2, 2008, Pages 195-202

  Xu, Yang ^a   Musson, Donald G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CGRP receptor antagonist; Diastereomer; Enantiomer; LC MS MS; MK 0974 (1a); Reversed phase chiral assay; Solid phase extraction (SPE)

Indexed keywords

96-WELL; CALCITONIN GENE-RELATED PEPTIDE; CARBOXAMIDE; CGRP RECEPTOR ANTAGONIST; CHIRAL CENTERS; CHIRAL INTEGRITY; CHIRAL LIQUID CHROMATOGRAPHY; CHIRAL STATIONARY PHASE; CIRCULATORY SYSTEMS; CLINICAL SAMPLES; COEFFICIENT OF VARIATION; DETECTION SENSITIVITY; DIASTEREOMER; ENANTIOMER; FREEZE/THAW CYCLES; HUMAN CONTROL; HUMAN PLASMAS; LC-MS/MS; MATRIX EFFECTS; MK-0974 (1A); MOBILE PHASE; REVERSED-PHASE; REVERSED-PHASE CHIRAL ASSAY; SAMPLE PREPARATIONS; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTION; SOLID-PHASE EXTRACTION (SPE); STATIONARY PHASE; TANDEM MASS SPECTROMETRIC DETECTION; TANDEM MASS SPECTROMETRY; TRIFLUOROACETATE;

AMINES; AMMONIUM COMPOUNDS; CARDIOVASCULAR SYSTEM; CELLULOSE DERIVATIVES; CHROMATOGRAPHIC ANALYSIS; DATA STORAGE EQUIPMENT; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PHASE INTERFACES; PHASE SEPARATION; PLASMA (HUMAN); PLASMAS; POLYSACCHARIDES; POSITIVE IONS; RELIABILITY; SEPARATION; SPECTROMETRY; STEREOCHEMISTRY;

LIQUID PHASE EPITAXY;

AZEPINONE 3 CARBON; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CARBON; CELLULOSE; MK 0974; N [6 (2,3 DIFLUOROPHENYL) 2 OXO 1 (2,2,2 TRIFUOROETHYL)AZEPAN 3 YL] 4 (2 OXO 2,3 DIHYDRO 1H IMIDAZO[4,5 B]PYRIDINE 1 YL)PIPERIDINE 1 CARBOXAMIDE; POLYSACCHARIDE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; BLOOD STORAGE; CARDIOVASCULAR SYSTEM; CHIRAL CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EXPOSURE; DRUG STRUCTURE; FREEZE THAWING; HUMAN; ISOMER; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

AZEPINES; CHROMATOGRAPHY, LIQUID; HUMANS; IMIDAZOLES; SOLID PHASE EXTRACTION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

AMINES; AMMONIUM COMPOUNDS; BLOOD; CELLULOSE; ISOMERS; LIQUID CHROMATOGRAPHY; PEPTIDES; POLYSACCHARIDES; RELIABILITY; STEREOCHEMISTRY;

EID: 52149123494     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.08.019     Document Type: Article

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