메뉴 건너뛰기




Volumn 15, Issue 4, 2009, Pages 353-361

The Potential Role of Erythropoietin in Chronic Heart Failure: From the Correction of Anemia to Improved Perfusion and Reduced Apoptosis?

Author keywords

Anemia; apoptosis; neovascularization

Indexed keywords

DARBE POIETIN ALFA; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ERYTHROPOIETIN; FERRIC HYDROXIDE SUCROSE; IRON; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG;

EID: 65249088498     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2008.10.024     Document Type: Review
Times cited : (26)

References (74)
  • 1
    • 4444256649 scopus 로고    scopus 로고
    • Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure. The Rotterdam Study
    • Bleumink G.S., Knetsch A.M., Sturkenboom M.C., et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure. The Rotterdam Study. Eur Heart J 25 (2004) 1614-1619
    • (2004) Eur Heart J , vol.25 , pp. 1614-1619
    • Bleumink, G.S.1    Knetsch, A.M.2    Sturkenboom, M.C.3
  • 2
    • 43749091242 scopus 로고    scopus 로고
    • The prevalence of anemia in chronic heart failure and its impact on the clinical outcomes
    • Tang Y.D., and Katz S.D. The prevalence of anemia in chronic heart failure and its impact on the clinical outcomes. Heart Fail Rev 13 (2008) 387-392
    • (2008) Heart Fail Rev , vol.13 , pp. 387-392
    • Tang, Y.D.1    Katz, S.D.2
  • 3
    • 17844403494 scopus 로고    scopus 로고
    • Prevalence of anemia and effects on mortality in patients with heart failure
    • Lindenfeld J. Prevalence of anemia and effects on mortality in patients with heart failure. Am Heart J 149 (2005) 391-401
    • (2005) Am Heart J , vol.149 , pp. 391-401
    • Lindenfeld, J.1
  • 4
    • 0043011312 scopus 로고    scopus 로고
    • Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure
    • Felker G.M., Gattis W.A., Leimberger J.D., et al. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. Am J Cardiol 92 (2003) 625-628
    • (2003) Am J Cardiol , vol.92 , pp. 625-628
    • Felker, G.M.1    Gattis, W.A.2    Leimberger, J.D.3
  • 5
    • 13944270337 scopus 로고    scopus 로고
    • Anemia in patients with heart failure: prevalence and prognostic role in a controlled trial and in clinical practice
    • Maggioni A.P., Opasich C., Anand I., et al. Anemia in patients with heart failure: prevalence and prognostic role in a controlled trial and in clinical practice. J Card Fail 11 (2005) 91-98
    • (2005) J Card Fail , vol.11 , pp. 91-98
    • Maggioni, A.P.1    Opasich, C.2    Anand, I.3
  • 6
    • 33748063277 scopus 로고    scopus 로고
    • Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy
    • Hamed S., Barshack I., Luboshits G., et al. Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy. Eur Heart J 27 (2006) 1876-1883
    • (2006) Eur Heart J , vol.27 , pp. 1876-1883
    • Hamed, S.1    Barshack, I.2    Luboshits, G.3
  • 7
    • 33745250458 scopus 로고    scopus 로고
    • Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs
    • Hirata A., Minamino T., Asanuma H., et al. Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs. J Am Coll Cardiol 48 (2006) 176-184
    • (2006) J Am Coll Cardiol , vol.48 , pp. 176-184
    • Hirata, A.1    Minamino, T.2    Asanuma, H.3
  • 8
    • 33644871048 scopus 로고    scopus 로고
    • Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy
    • Li L., Takemura G., Li Y., et al. Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy. Circulation 113 (2006) 535-543
    • (2006) Circulation , vol.113 , pp. 535-543
    • Li, L.1    Takemura, G.2    Li, Y.3
  • 9
    • 33745025709 scopus 로고    scopus 로고
    • A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study
    • Lipsic E., van der Meer P., Voors A.A., et al. A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study. Cardiovasc Drugs Ther 20 (2006) 135-141
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 135-141
    • Lipsic, E.1    van der Meer, P.2    Voors, A.A.3
  • 10
    • 37549020370 scopus 로고    scopus 로고
    • Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit
    • Lipsic E., Westenbrink B.D., van der Meer P., et al. Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit. Eur J Heart Fail. 10 (2008) 22-29
    • (2008) Eur J Heart Fail. , vol.10 , pp. 22-29
    • Lipsic, E.1    Westenbrink, B.D.2    van der Meer, P.3
  • 11
    • 33846188979 scopus 로고    scopus 로고
    • Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells
    • Prunier F., Pfister O., Hadri L., et al. Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. Am J Physiol Heart Circ Physiol 292 (2007) H522-H529
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Prunier, F.1    Pfister, O.2    Hadri, L.3
  • 12
    • 21344459065 scopus 로고    scopus 로고
    • Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction
    • van der Meer P., Lipsic E., Henning R.H., et al. Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction. J Am Coll Cardiol 46 (2005) 125-133
    • (2005) J Am Coll Cardiol , vol.46 , pp. 125-133
    • van der Meer, P.1    Lipsic, E.2    Henning, R.H.3
  • 13
    • 34848832453 scopus 로고    scopus 로고
    • Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization
    • Westenbrink B.D., Lipsic E., van der Meer P., et al. Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization. Eur Heart J 28 (2007) 2018-2027
    • (2007) Eur Heart J , vol.28 , pp. 2018-2027
    • Westenbrink, B.D.1    Lipsic, E.2    van der Meer, P.3
  • 14
    • 48349123947 scopus 로고    scopus 로고
    • Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    • Westenbrink B.D., Oeseburg H., Kleijn L., et al. Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia. Cardiovasc Drugs Ther 22 (2008) 265-274
    • (2008) Cardiovasc Drugs Ther , vol.22 , pp. 265-274
    • Westenbrink, B.D.1    Oeseburg, H.2    Kleijn, L.3
  • 15
    • 33748137740 scopus 로고    scopus 로고
    • Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase
    • Burger D., Lei M., Geoghegan-Morphet N., et al. Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovasc Res 72 (2006) 51-59
    • (2006) Cardiovasc Res , vol.72 , pp. 51-59
    • Burger, D.1    Lei, M.2    Geoghegan-Morphet, N.3
  • 16
    • 0037447256 scopus 로고    scopus 로고
    • Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
    • Calvillo L., Latini R., Kajstura J., et al. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci U S A 100 (2003) 4802-4806
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4802-4806
    • Calvillo, L.1    Latini, R.2    Kajstura, J.3
  • 17
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong Z.Z., Kang J.Q., and Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106 (2002) 2973-2979
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 18
    • 0141593556 scopus 로고    scopus 로고
    • Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats
    • Moon C., Krawczyk M., Ahn D., et al. Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats. Proc Natl Acad Sci U S A 100 (2003) 11612-11617
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11612-11617
    • Moon, C.1    Krawczyk, M.2    Ahn, D.3
  • 19
    • 85047691007 scopus 로고    scopus 로고
    • A novel protective effect of erythropoietin in the infarcted heart
    • Parsa C.J., Matsumoto A., Kim J., et al. A novel protective effect of erythropoietin in the infarcted heart. J Clin Invest 112 (2003) 999-1007
    • (2003) J Clin Invest , vol.112 , pp. 999-1007
    • Parsa, C.J.1    Matsumoto, A.2    Kim, J.3
  • 20
    • 2442714969 scopus 로고    scopus 로고
    • Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts
    • Parsa C.J., Kim J., Riel R.U., et al. Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts. J Biol Chem 279 (2004) 20655-20662
    • (2004) J Biol Chem , vol.279 , pp. 20655-20662
    • Parsa, C.J.1    Kim, J.2    Riel, R.U.3
  • 21
    • 0041659121 scopus 로고    scopus 로고
    • Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway
    • Tramontano A.F., Muniyappa R., Black A.D., et al. Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway. Biochem Biophys Res Commun 308 (2003) 990-994
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 990-994
    • Tramontano, A.F.1    Muniyappa, R.2    Black, A.D.3
  • 22
    • 0033604519 scopus 로고    scopus 로고
    • Signal transduction in the erythropoietin receptor system
    • Wojchowski D.M., Gregory R.C., Miller C.P., et al. Signal transduction in the erythropoietin receptor system. Exp Cell Res. 253 (1999) 143-156
    • (1999) Exp Cell Res. , vol.253 , pp. 143-156
    • Wojchowski, D.M.1    Gregory, R.C.2    Miller, C.P.3
  • 23
    • 40049100802 scopus 로고    scopus 로고
    • Anemia in chronic heart failure: etiology and treatment options
    • Westenbrink B.D., de Boer R.A., Voors A.A., et al. Anemia in chronic heart failure: etiology and treatment options. Curr Opin Cardiol 23 (2008) 141-147
    • (2008) Curr Opin Cardiol , vol.23 , pp. 141-147
    • Westenbrink, B.D.1    de Boer, R.A.2    Voors, A.A.3
  • 24
    • 33745961565 scopus 로고    scopus 로고
    • Anemia, renal dysfunction, and their interaction in patients with chronic heart failure
    • de Silva R., Rigby A.S., Witte K.K., et al. Anemia, renal dysfunction, and their interaction in patients with chronic heart failure. Am J Cardiol 98 (2006) 391-398
    • (2006) Am J Cardiol , vol.98 , pp. 391-398
    • de Silva, R.1    Rigby, A.S.2    Witte, K.K.3
  • 25
    • 27544491237 scopus 로고    scopus 로고
    • Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure
    • Opasich C., Cazzola M., Scelsi L., et al. Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. Eur Heart J 26 (2005) 2232-2237
    • (2005) Eur Heart J , vol.26 , pp. 2232-2237
    • Opasich, C.1    Cazzola, M.2    Scelsi, L.3
  • 26
    • 33847053226 scopus 로고    scopus 로고
    • Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well
    • Westenbrink B.D., Visser F.W., Voors A.A., et al. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur Heart J 28 (2007) 166-171
    • (2007) Eur Heart J , vol.28 , pp. 166-171
    • Westenbrink, B.D.1    Visser, F.W.2    Voors, A.A.3
  • 28
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G., and Goodnough L.T. Anemia of chronic disease. N Engl J Med 352 (2005) 1011-1023
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 29
    • 4444303194 scopus 로고    scopus 로고
    • The interaction between heart failure, renal failure and anemia-the cardio-renal anemia syndrome
    • Silverberg D.S., Wexler D., Blum M., et al. The interaction between heart failure, renal failure and anemia-the cardio-renal anemia syndrome. Blood Purif 22 (2004) 277-284
    • (2004) Blood Purif , vol.22 , pp. 277-284
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 30
    • 0037458095 scopus 로고    scopus 로고
    • Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12065 patients with new-onset heart failure
    • Ezekowitz J.A., McAlister F.A., and Armstrong P.W. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12065 patients with new-onset heart failure. Circulation 107 (2003) 223-225
    • (2003) Circulation , vol.107 , pp. 223-225
    • Ezekowitz, J.A.1    McAlister, F.A.2    Armstrong, P.W.3
  • 31
    • 33845299533 scopus 로고    scopus 로고
    • Etiology of anemia in patients with advanced heart failure
    • Nanas J.N., Matsouka C., Karageorgopoulos D., et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 48 (2006) 2485-2489
    • (2006) J Am Coll Cardiol , vol.48 , pp. 2485-2489
    • Nanas, J.N.1    Matsouka, C.2    Karageorgopoulos, D.3
  • 32
    • 13244268473 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction
    • Ishani A., Weinhandl E., Zhao Z., et al. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 45 (2005) 391-399
    • (2005) J Am Coll Cardiol , vol.45 , pp. 391-399
    • Ishani, A.1    Weinhandl, E.2    Zhao, Z.3
  • 33
    • 0032792965 scopus 로고    scopus 로고
    • The role of ACE inhibitors and angiotensin II receptor blockers in the response to epoetin
    • Macdougall I.C. The role of ACE inhibitors and angiotensin II receptor blockers in the response to epoetin. Nephrol Dial Transplant 14 (1999) 1836-1841
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 1836-1841
    • Macdougall, I.C.1
  • 34
    • 32944454579 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for chronic renal failure anaemia in pre-dialysis patients
    • CD003266
    • Cody J., Daly C., Campbell M., et al. Recombinant human erythropoietin for chronic renal failure anaemia in pre-dialysis patients. Cochrane Database Syst Rev 3 (2005) CD003266
    • (2005) Cochrane Database Syst Rev , vol.3
    • Cody, J.1    Daly, C.2    Campbell, M.3
  • 35
    • 0033928280 scopus 로고    scopus 로고
    • Erythroid progenitors differentiate and mature in response to endogenous erythropoietin
    • Sato T., Maekawa T., Watanabe S., et al. Erythroid progenitors differentiate and mature in response to endogenous erythropoietin. J Clin Invest 106 (2000) 263-270
    • (2000) J Clin Invest , vol.106 , pp. 263-270
    • Sato, T.1    Maekawa, T.2    Watanabe, S.3
  • 36
    • 33751002326 scopus 로고    scopus 로고
    • Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    • Drueke T.B., Locatelli F., Clyne N., et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355 (2006) 2071-2084
    • (2006) N Engl J Med , vol.355 , pp. 2071-2084
    • Drueke, T.B.1    Locatelli, F.2    Clyne, N.3
  • 37
    • 56149104881 scopus 로고    scopus 로고
    • Effects of darbepoetin-alpha on quality of life and emotional stress in anemic patients with chronic heart failure
    • Kourea K., Parissis J.T., Farmakis D., et al. Effects of darbepoetin-alpha on quality of life and emotional stress in anemic patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 15 (2008) 365-369
    • (2008) Eur J Cardiovasc Prev Rehabil , vol.15 , pp. 365-369
    • Kourea, K.1    Parissis, J.T.2    Farmakis, D.3
  • 38
    • 0037458127 scopus 로고    scopus 로고
    • Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure
    • Mancini D.M., Katz S.D., Lang C.C., et al. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation 107 (2003) 294-299
    • (2003) Circulation , vol.107 , pp. 294-299
    • Mancini, D.M.1    Katz, S.D.2    Lang, C.C.3
  • 39
    • 33845216454 scopus 로고    scopus 로고
    • Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia
    • 1096.e9-15
    • Palazzuoli A., Silverberg D., Iovine F., et al. Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. Am Heart J 152 (2006) 1096.e9-15
    • (2006) Am Heart J , vol.152
    • Palazzuoli, A.1    Silverberg, D.2    Iovine, F.3
  • 40
    • 34548767764 scopus 로고    scopus 로고
    • Effects of beta-erythropoietin treatment on left ventricular remodeling, systolic function, and B-type natriuretic peptide levels in patients with the cardiorenal anemia syndrome
    • 645.e9-15
    • Palazzuoli A., Silverberg D.S., Iovine F., et al. Effects of beta-erythropoietin treatment on left ventricular remodeling, systolic function, and B-type natriuretic peptide levels in patients with the cardiorenal anemia syndrome. Am Heart J 154 (2007) 645.e9-15
    • (2007) Am Heart J , vol.154
    • Palazzuoli, A.1    Silverberg, D.S.2    Iovine, F.3
  • 41
    • 33846936320 scopus 로고    scopus 로고
    • Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial
    • Ponikowski P., Anker S.D., Szachniewicz J., et al. Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 49 (2007) 753-762
    • (2007) J Am Coll Cardiol , vol.49 , pp. 753-762
    • Ponikowski, P.1    Anker, S.D.2    Szachniewicz, J.3
  • 42
    • 0034128813 scopus 로고    scopus 로고
    • The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations
    • Silverberg D.S., Wexler D., Blum M., et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol 35 (2000) 1737-1744
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1737-1744
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 43
    • 0035370037 scopus 로고    scopus 로고
    • The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study
    • Silverberg D.S., Wexler D., Sheps D., et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study. J Am Coll Cardiol 37 (2001) 1775-1780
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1775-1780
    • Silverberg, D.S.1    Wexler, D.2    Sheps, D.3
  • 44
    • 11344262637 scopus 로고    scopus 로고
    • Effects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure
    • Silverberg D.S., Wexler D., Blum M., et al. Effects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure. Kidney Blood Press Res 28 (2005) 41-47
    • (2005) Kidney Blood Press Res , vol.28 , pp. 41-47
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3
  • 45
    • 34548798205 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia
    • van Veldhuisen D.J., Dickstein K., Cohen-Solal A., et al. Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia. Eur Heart J 28 (2007) 2208-2216
    • (2007) Eur Heart J , vol.28 , pp. 2208-2216
    • van Veldhuisen, D.J.1    Dickstein, K.2    Cohen-Solal, A.3
  • 46
    • 41049115024 scopus 로고    scopus 로고
    • Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia
    • Ghali J.K., Anand I.S., Abraham W.T., et al. Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia. Circulation 117 (2008) 526-535
    • (2008) Circulation , vol.117 , pp. 526-535
    • Ghali, J.K.1    Anand, I.S.2    Abraham, W.T.3
  • 47
    • 17844369963 scopus 로고    scopus 로고
    • Rationale-Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT): evolving the management of cardiovascular risk in patients with chronic kidney disease
    • Mix T.C., Brenner R.M., Cooper M.E., et al. Rationale-Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT): evolving the management of cardiovascular risk in patients with chronic kidney disease. Am Heart J 149 (2005) 408-413
    • (2005) Am Heart J , vol.149 , pp. 408-413
    • Mix, T.C.1    Brenner, R.M.2    Cooper, M.E.3
  • 48
    • 24644520622 scopus 로고    scopus 로고
    • Expression of the erythropoietin receptor in human heart
    • Depping R., Kawakami K., Ocker H., et al. Expression of the erythropoietin receptor in human heart. J Thorac Cardiovasc Surg 130 (2005) 877-878
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 877-878
    • Depping, R.1    Kawakami, K.2    Ocker, H.3
  • 49
    • 9144258353 scopus 로고    scopus 로고
    • Erythropoietin regulates endothelial progenitor cells
    • Bahlmann F.H., de G.K., Spandau J.M., et al. Erythropoietin regulates endothelial progenitor cells. Blood 103 (2004) 921-926
    • (2004) Blood , vol.103 , pp. 921-926
    • Bahlmann, F.H.1    de, G.K.2    Spandau, J.M.3
  • 50
    • 4143052506 scopus 로고    scopus 로고
    • Endothelial progenitor cells: characterization and role in vascular biology
    • Urbich C., and Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 95 (2004) 343-353
    • (2004) Circ Res , vol.95 , pp. 343-353
    • Urbich, C.1    Dimmeler, S.2
  • 51
    • 41349098142 scopus 로고    scopus 로고
    • Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension
    • Watson T., Goon P.K., and Lip G.Y. Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension. Antioxid Redox Signal 10 (2008) 1079-1088
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1079-1088
    • Watson, T.1    Goon, P.K.2    Lip, G.Y.3
  • 52
    • 24344442873 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells and cardiovascular outcomes
    • Werner N., Kosiol S., Schiegl T., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 353 (2005) 999-1007
    • (2005) N Engl J Med , vol.353 , pp. 999-1007
    • Werner, N.1    Kosiol, S.2    Schiegl, T.3
  • 53
    • 33646433695 scopus 로고    scopus 로고
    • Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels
    • Zentilin L., Tafuro S., Zacchigna S., et al. Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels. Blood 107 (2006) 3546-3554
    • (2006) Blood , vol.107 , pp. 3546-3554
    • Zentilin, L.1    Tafuro, S.2    Zacchigna, S.3
  • 54
    • 0001377920 scopus 로고
    • Myocardial metabolism in congestive heart failure
    • Olson R.E. Myocardial metabolism in congestive heart failure. J Chronic Dis 9 (1959) 442-464
    • (1959) J Chronic Dis , vol.9 , pp. 442-464
    • Olson, R.E.1
  • 55
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley W.C., Recchia F.A., and Lopaschuk G.D. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85 (2005) 1093-1129
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 57
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart-an engine out of fuel
    • Neubauer S. The failing heart-an engine out of fuel. N Engl J Med 356 (2007) 1140-1151
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 58
    • 0033978052 scopus 로고    scopus 로고
    • Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy
    • van den Heuvel A.F., van Veldhuisen D.J., van der Wall E.E., et al. Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 35 (2000) 19-28
    • (2000) J Am Coll Cardiol , vol.35 , pp. 19-28
    • van den Heuvel, A.F.1    van Veldhuisen, D.J.2    van der Wall, E.E.3
  • 59
    • 85047677578 scopus 로고
    • Ischaemic myocardial injury and ventricular remodelling
    • Anversa P., Li P., Zhang X., et al. Ischaemic myocardial injury and ventricular remodelling. Cardiovasc Res 27 (1993) 145-157
    • (1993) Cardiovasc Res , vol.27 , pp. 145-157
    • Anversa, P.1    Li, P.2    Zhang, X.3
  • 60
    • 1042286928 scopus 로고    scopus 로고
    • The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities
    • de Boer R.A., Pinto Y.M., and van Veldhuisen D.J. The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities. Microcirculation 10 (2003) 113-126
    • (2003) Microcirculation , vol.10 , pp. 113-126
    • de Boer, R.A.1    Pinto, Y.M.2    van Veldhuisen, D.J.3
  • 61
    • 6344225691 scopus 로고    scopus 로고
    • Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury
    • Wright G.L., Hanlon P., Amin K., et al. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. FASEB J 18 (2004) 1031-1033
    • (2004) FASEB J , vol.18 , pp. 1031-1033
    • Wright, G.L.1    Hanlon, P.2    Amin, K.3
  • 62
    • 0026630603 scopus 로고
    • Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase
    • Clancy R.M., Leszczynska-Piziak J., and Abramson S.B. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 90 (1992) 1116-1121
    • (1992) J Clin Invest , vol.90 , pp. 1116-1121
    • Clancy, R.M.1    Leszczynska-Piziak, J.2    Abramson, S.B.3
  • 63
    • 18144387916 scopus 로고    scopus 로고
    • Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure
    • Razavi H.M., Hamilton J.A., and Feng Q. Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure. Pharmacol Ther 106 (2005) 147-162
    • (2005) Pharmacol Ther , vol.106 , pp. 147-162
    • Razavi, H.M.1    Hamilton, J.A.2    Feng, Q.3
  • 64
    • 34447513916 scopus 로고    scopus 로고
    • Positive effect of darbepoetin on peri-infarction remodeling in a porcine model of myocardial ischemia-reperfusion
    • Toma C., Letts D.P., Tanabe M., et al. Positive effect of darbepoetin on peri-infarction remodeling in a porcine model of myocardial ischemia-reperfusion. J Mol Cell Cardiol 43 (2007) 130-136
    • (2007) J Mol Cell Cardiol , vol.43 , pp. 130-136
    • Toma, C.1    Letts, D.P.2    Tanabe, M.3
  • 65
    • 33750983605 scopus 로고    scopus 로고
    • Correction of anemia with epoetin alfa in chronic kidney disease
    • Singh A.K., Szczech L., Tang K.L., et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355 (2006) 2085-2098
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3
  • 66
    • 0142186283 scopus 로고    scopus 로고
    • Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial
    • Henke M., Laszig R., Rübe C., et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 362 (2003) 1255-1260
    • (2003) Lancet , vol.362 , pp. 1255-1260
    • Henke, M.1    Laszig, R.2    Rübe, C.3
  • 67
    • 24944454286 scopus 로고    scopus 로고
    • Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study
    • Leyland-Jones B., Semiglazov V., Pawlicki M., et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol 23 (2005) 5960-5972
    • (2005) J Clin Oncol , vol.23 , pp. 5960-5972
    • Leyland-Jones, B.1    Semiglazov, V.2    Pawlicki, M.3
  • 68
    • 44949145219 scopus 로고    scopus 로고
    • Concern about the safety of erythropoietin in cancer patients
    • van der Lelie J. Concern about the safety of erythropoietin in cancer patients. Ned Tijdschr Geneeskd 152 (2008) 920-922
    • (2008) Ned Tijdschr Geneeskd , vol.152 , pp. 920-922
    • van der Lelie, J.1
  • 69
    • 33847785149 scopus 로고    scopus 로고
    • Are erythropoietin stimulating proteins safe and efficacious in heart failure? Why we need an adequately powered randomised outcome trial
    • van Veldhuisen D.J., and McMurray J.J. Are erythropoietin stimulating proteins safe and efficacious in heart failure? Why we need an adequately powered randomised outcome trial. Eur J Heart Fail 9 (2007) 110-112
    • (2007) Eur J Heart Fail , vol.9 , pp. 110-112
    • van Veldhuisen, D.J.1    McMurray, J.J.2
  • 70
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M., Ghezzi P., Grasso G., et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305 (2004) 239-242
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3
  • 71
    • 13844320400 scopus 로고    scopus 로고
    • A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury
    • Fiordaliso F., Chimenti S., Staszewsky L., et al. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci U S A 102 (2005) 2046-2051
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2046-2051
    • Fiordaliso, F.1    Chimenti, S.2    Staszewsky, L.3
  • 72
    • 33644775862 scopus 로고    scopus 로고
    • Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties
    • Moon C., Krawczyk M., Paik D., et al. Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties. J Pharmacol Exp Ther 316 (2006) 999-1005
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 999-1005
    • Moon, C.1    Krawczyk, M.2    Paik, D.3
  • 73
    • 33748438999 scopus 로고    scopus 로고
    • Intravenous iron alone for the treatment of anemia in patients with chronic heart failure
    • Bolger A.P., Bartlett F.R., Penston H.S., et al. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. J Am Coll Cardiol 48 (2006) 1225-1227
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1225-1227
    • Bolger, A.P.1    Bartlett, F.R.2    Penston, H.S.3
  • 74
    • 35248870765 scopus 로고    scopus 로고
    • Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    • Toblli J.E., Lombrana A., Duarte P., et al. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 50 (2007) 1657-1665
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1657-1665
    • Toblli, J.E.1    Lombrana, A.2    Duarte, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.