Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: A randomised, double-blind, controlled pilot study

Complementary Therapies in Medicine

Volumn 17, Issue 3, 2009, Pages 141-146

  Cho, J H ^a   Cho, C K ^a   Shin, J W ^a   Son, J Y ^a   Kang, W ^b   Son, C G ^a  

^a East West Cancer Center   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Astragalus membranaceus; Chronic fatigue; Herbal medicine; Salvia miltiorrhiza

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; CYTOKINE; MYELOPHIL; PLACEBO; PLANT EXTRACT; SALVIA MILTIORRHIZA EXTRACT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTRAGALUS MEMBRANACEUS; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; FATIGUE; FEMALE; HUMAN; LOW DRUG DOSE; MALE; PILOT STUDY; PLANT ROOT; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SALVIA MILTIORRHIZA; TRADITIONAL MEDICINE; TREATMENT OUTCOME;

ADULT; ASTRAGALUS MEMBRANACEUS; CYTOKINES; DOUBLE-BLIND METHOD; DRUGS, CHINESE HERBAL; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; SALVIA MILTIORRHIZA; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 65049088110     PISSN: 09652299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ctim.2008.11.003     Document Type: Article

References (33)

1. Fukuda K., Straus S.E., Hickie I., Sharpe M.C., Dobbins J.G., and Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 121 (1994) 953-959
2. Martin A., Chalder T., Rief W., and Braehler E. The relationship between chronic fatigue and somatization syndrome: a general population survey. J Psychosom Res 63 2 (2007) 147-156
3. Loge J.H., Ekeberg O., and Kaasa S. Fatigue in the general Norwegian population: normative data and associations. J Psychosom Res 45 1 spec. no. (1998) 53-65
4. Kim C.H., Shin H.C., and Won C.W. Prevalence of chronic fatigue and chronic fatigue syndrome in Korea: community-based primary care study. J Korean Med Sci 20 (2005) 529-534
5. Reeves W.C., Jones J.F., Maloney E., et al. Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia. Popul Health Metr 8 (2007) 5
6. Jones J.F., Maloney E.M., Boneva R.S., Jones A.B., and Reeves W.C. Complementary and alternative medical therapy utilization by people with chronic fatiguing illnesses in the United States. BMC Complement Altern Med 25 (2007) 7-12
7. Yiu Y.M., and Qiu M.Y. A preliminary epidemiological study and discussion on traditional Chinese medicine pathogenesis of chronic fatigue syndrome in Hong Kong. Zhong Xi Yi Jie He Xue Bao 3 (2005) 359-362
8. Hartz A.J., Bentler S., Noyes R., et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 34 (2004) 51-61
9. Sekiya N., Shimada Y., Shintani T., et al. Reduction of perception of chronic fatigue in an observational study of patients receiving 12 weeks of Kampo therapy. J Altern Complement Med 11 (2005) 895-901
10. Lijue Z. Acupuncture and Chinese patent drugs for treatment of chronic fatigue syndrome. J Tradit Chin Med 25 (2005) 99-101
11. Cho W.C., and Leung K.N. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol 113 (2007) 132-141
12. Li R.J., Qiu S.D., Chen H.X., Tian H., and Wang H.X. The immunotherapeutic effects of Astragalus polysaccharide in type 1 diabetic mice. Biol Pharm Bull 30 (2007) 470-476
13. Lei H., Wang B., Li W.P., Yang Y., Zhou A.W., and Chen M.Z. Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacol Sin 24 (2003) 230-234
14. Cho W.C., and Leung K.N. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett 252 (2007) 43-54
15. Ji X., Tan B.K., Zhu Y.C., Linz W., and Zhu Y.Z. Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats. Life Sci 73 (2003) 1413-1426
16. Liu J., Shen H.M., and Ong C.N. Role of intracellular thiol depletion, mitochondrial function and reactive oxygen species in Salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells. Life Sci 69 (2001) 1833-1850
17. Koo B.S., Kwon T.S., and Kim C.H. Salviae miltiorrhizae radix inhibits superoxide generation by activated rat microglias and mimics the action of amphetamine on in vitro rat striatal dopamine release. Neurochem Res 29 (2004) 1837-1845
18. Chalder T., Berelowitz G., Pawlikowska T., et al. Development of a fatigue scale. J Psychosom Res 37 (1993) 147-153
19. Morriss R.K., Wearden A.J., and Mullis R. Exploring the validity of the Chalder fatigue scale in chronic fatigue syndrome. J Psychosom Res 45 (1998) 411-417
20. ® system for mixed models (1996), SAS Institute Inc., Cary, NC
21. Bentler S.E., Hartz A.J., and Kuhn E.M. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry 66 (2005) 625-632
22. Weatherley-Jones E., Nicholl J.P., Thomas K.J., et al. A randomised, controlled, triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndrome. J Psychosom Res 56 (2004) 189-197
23. Spector R., and Vesell E.S. Pharmacology and statistics: recommendations to strengthen a productive partnership. Pharmacology 78 (2006) 113-122 [Epub 27 September 2006]
24. Tirelli U., Marotta G., Improta S., and Pinto A. Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol 40 (1994) 601-608
25. Robertson M.J., Schacterle R.S., Mackin G.A., et al. Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression. Clin Exp Immunol 141 (2005) 326-332
26. Tomoda A., Joudoi T., Rabab el-M, Matsumoto T., Park T.H., and Miike T. Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls. Psychiatry Res 134 (2005) 101-104
27. Mihaylova I., Deruyter M., Rummens J.L., Bosmans E., and Maes M. Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells. Neuro Endocrinol Lett 11 (2007) 28(4)
28. Chao C.C., Janoff E.N., Hu S.X., et al. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome. Cytokine 3 (1991) 292-298
29. Amel Kashipaz M.R., Swinden D., Todd I., and Powell R.J. Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells. Clin Exp Immunol 132 (2003) 360-365
30. Baker R., and Shaw E.J. Diagnosis and management of chronic fatigue syndrome or myalgic encephalomyelitis (or encephalopathy): summary of NICE guidance. BMJ 335 (2007) 446-448
31. Zhu X.L., and Zhu B.D. Mechanisms by which Astragalus membranaceus injection regulates hematopoiesis in myelosuppressed mice. Phytother Res 21 (2007) 663-667
32. Tang M.K., Ren D.C., Zhang J.T., and Du G.H. Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats. Phytomedicine 9 (2002) 405-409
33. Park J.W., Lee S.H., Yang M.K., et al. 15,16-Dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch Pharm Res 31 (2008) 47-53