Comparative analysis of prognostic significance of molecular markers of apoptosis with clinical stage and tumor differentiation in patients with colorectal cancer: A single institute experience

Hepato-Gastroenterology

Volumn 56, Issue 89, 2009, Pages 94-98

  Ivanov, K ^a   Kolev, N ^a   Tonev, A ^a   Nikolova, G ^b   Krasnaliev, I ^b   Softova, E ^b   Tonchev, A ^b  

^a UNIVERSITY HOSPITAL ST MARINA   (Bulgaria)

^b MEDICAL UNIVERSITY OF VARNA   (Bulgaria)

Author keywords

Apoptosis; Colorectal cancer; Correlation; TNM

Indexed keywords

MOLECULAR MARKER; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER GRADING; CANCER STAGING; COLORECTAL CANCER; COLORECTAL SURGERY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR BIOPSY; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; ADULT; AGED; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOPSY; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 64949164868     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Kørner H, Søreide K, Stokkeland PJ, Traeland JH, Søreide JA: Surveillance after curative resection for colorectal cancer Tidsskr Nor Laegeforen 2007; 127:2959-2962.
2. Hasdemir O, Cöl C, Yalçin E, Tunç G, Bilgen K, Kuçukpinar T: Local recurrence and survival rates after extended systematic lymph-node dissection for surgical treatment of rectal cancer. Hepatogastroenterology 2005; 52:455-9.
3. Safioleas MC, Moulakakis KG, Stamatakos M, Kountouras J, Lygidakis NJ: Local recurrence following curative low anterior resection for rectal carcinoma. Hepatogastroenterology 2005; 52:94-96.
4. Søreide JA, Eiriksson K, Sandvik O, Viste A, Horn A, Johnsen G, Grønbech JE: Surgical treatment of liver metastases from colorectal cancer Tidsskr Nor Laegeforen. 2008;128:50-53.
5. Tanaka K, Shimada H, Ueda M, Matsuo K, Endo I, Togo S: Role of hepatectomy in treating multiple bilobar colorectal cancer metastases. Surgery 2008;143:259-270.
6. Quirke P, Williams GT, Ectors N, Ensari A, Piard F, Nagtegaal I. The future of the TNM staging system in colorectal cancer: time for a debate? Lancet Oncol. 2007; 8:651-657.
7. Fang WL, Chang SC, Lin JK, Wang HS, Yang SH, Jiang JK, Chen WC, Lin TC: Metastatic potential in T1 and T2 colorectal cancer. Hepatogastroenterology 2005; 52:1688-1691.
8. Fernandez-Cebrian JM, Nevado Santos M, Vorwald Kuborn P, Pardo de Lama M, Martin-Cavanna J, Pacheco Martinez P, Fernandez Escudero B, Ramos Fernandez M: Can the clinical outcome in stage II colon carcinomas be predicted by determination of molecular marker expression? Clin Transl Oncol. 2007; 9:663-670.
9. Otchy D, Hyman N, Simmang C, Anthony Th, Buie W, Cataldo P, Church J, Cohen J, Dentsman F, Ellis C, Kilkenny J, Ko Cl, Moore R, Orsay Ch, Place R, Rafferty J, Rakinic P, Savoca J, Tjandra M: Whiteford Practice Parameters for Colon Cancer Dis Colon Rectum 2004; 47: 1269-1284.
10. Compton CC, Fenoglio-Preiser CM, Pettigrew N, Fielding LP: American Joint Committee on Cancer Prognostic Factors consensus conference: Colorectal Working Group. Cancer 2000; 88:1739-1757.
11. Steele G, Ellenberg S, Ramming K et al: CEA monitoring among patients in multi-institutional adjuvant therapy protocols. Ann. Surg. 1982; 196:162-169.
12. Compton CC, Fielding LP, Burgart LJ, et al: Prognostic factors in colorectal cancer: College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 2000; 124:979-994.
13. Karam JA, Lotan Y, Karakiewicz PI, Ashfaq R, Sagalowsky AI, Roehrborn CG, Shariat SF: Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy. Lancet Oncol. 2007; 8: 28-36.
14. Scorrano L, Korsmeyer SJ: Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem. Biophys. Res. Commun. 2003; 304:437-444.
15. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lhidsten T, Korsmeyer SJ: BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001; 8:705-711.
16. Kondo et al: Expression of Phosphorylated Ser70 of Bcl-2 Correlates with Malignancy in Human Colorectal Neoplasms. Clinical Cancer Research 2005; 11:7255-7263.
17. Hastak K, Agarwal MK, Mukhtar H: Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate The FASEB Journal. Published online, 2005.
18. Lin Q., R. Lai, L. R. Chirieac, Ch. Li, et al: Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells American Journal of Pathology 2005; 167: no 4.
19. Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80:293-299.
20. Berberoglu U: Prognostic significance of total lymph node number in patients with T1-4N0M0 colorectal cancer. Hepatogastroenterology 2004; 51:1689-1693.
21. Yamamoto S, Watanabe M, Hasegawa H, Baba H, Yoshinare K, Shiraishi J, Kitajima M: The risk of lymph node metastasis in T1 colorectal carcinoma. Hepatogastroenterology 2004; 51:998-1000.
22. Green FL: Current TNM staging of colorectal cancer Lancet Oncol. 2007; 8:572-583.
23. Gross A, McDonnell TJ, Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13:1899-1911.
24. Troisi RJ, Freedman AN, Devesa SS: Incidence of colorectal carcinoma in the U.S.: an update of trends by gender, race, age, subsite, and stage, 1975-1994. Cancer 1999; 85: 1670-1676.
25. Zlobec I, Lugli A: Prognostic and predictive factors in colorectal cancer: A critical review. J Clin Pathol. 2008.
26. Landis SH, Murray T, Bolden S, Wingo PA: Camr tistics. CA Cancer J Clin 1999; 49:8-31.
27. Khafagy W, El-Ghazaly M, El-Shobaky M, Kh Colorectal cancer in Egypt - Does it differ? Colopractics 2000; 22:109-115.
28. Soliman AS, Bondy ML, El-Badawy SA, Eissa S, Bayoumy S, et al: Contrasting molecular piogy of colorectal carcinoma in Egyptian and Wed patients. Br J Cancer 2001; 85:1037-1046.
29. Gryfe R, Swallow C, Bapat B, Redston M, Gallingu Couture J: Molecular biology of colorectal cancer. C. Probl Cancer 1997; 21:233-300.