Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds

British Journal of Dermatology

Volumn 135, Issue 1, 1996, Pages 52-59

  Vaalamo, M ^b   Weckroth, M ^b   Puolakkainen, P ^a   Kere, J ^b   Saarinen, P ^a   Lauharanta, J ^a   Saarialho Kere, U K ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; MESSENGER RNA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; UROKINASE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; WOUND HEALING;

EID: 0029943232     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.1996.tb03607.x     Document Type: Article

References (38)

1. Gailit J, Clark RAF. Wound repair in the context of extracellular matrix. Curr Opin Cell Biol 1994; 6: 717-25.
2. Matrisian LM. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 1990; 6: 121-5.
3. Woessner JF. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991; 5: 2145-54.
4. Schäfer BM, Maier K, Eickhoff U et al. Plasminogen activation in healing human wounds. Am J Pathol 1944; 144: 1269-80.
5. Saarialho-Kere UK, Kovacs SO, Pentland AP et al. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J Clin Invest 1993; 92: 2858-66.
6. Saarialho-Kere UK, Pentland AP, Birkedal-Hansen H et al. Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds. J Clin Invest 1994; 94: 79-88.
7. Ågren MS. Gelatinase activity during wound healing. Br J Dermatol 1994; 131: 634-40.
8. Salo T, Mäkelä M, Kylmäniemi M et al. Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab Invest 1994; 70: 176-82.
9. He CS, Wilhelm SM, Pentland AP et al. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci USA 1989; 86: 2632-6.
10. Stricklin GP, Welgus HG. Human skin fibroblast collagenase inhibitor: Purification and biochemical characterization. J Biol Chem 1983; 258: 12252-8.
11. Welgus HG, Campbell EJ, Cury JD et al. Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation and expression during cellular development. J Clin Invest 1990; 86: 1496-502.
12. Higley HR, Ksander GA, Gerhardt CO, Falanga V. Extravasation of macromolecules and possible trapping of transforming growth factor-β in venous ulceration. Br J Dermatol 1995; 132: 79-85.
13. Falanga V, Grinnell F, Gilchrest B et al. Workshop on the pathogenesis of chronic wounds. J Invest Dermatol 1994; 102: 125-7.
14. Wysocki AB, Staiano-Coico L, Grinnell F. Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J Invest Dermatol 1993; 101: 64-8.
15. Ceilley RI, Rinek MA, Zuehlke RL. Pinch grafting for chronic ulcers on lower extremities. J Dermatol Surg Oncol 1977; 3: 303-9.
16. Poskitt KR, James AH, Lloyd-Davies ERV et al. Pinch skin grafting or porcine dermis in venous ulcers: a randomised clinical trial. Br Med J 1987; 294: 674-6.
17. Winter GD. Formation of the scab and the rate of epithelialisation of superficial wounds in the skin of the young domestic pig. Nature 1962; 193: 293-4.
18. Schroder T, Hukki J, Castren M et al. Comparison of surgical lasers and conventional methods in skin incisions. Scand J Plast Reconstr Surg 1989; 23: 187-90
19. Prosser JW, Stenmark KR, Suthar M et al. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization. Am P Pathol 1989; 135: 1073-88.
20. Saarialho-Kere UK, Chang ES, Welgus HG, Parks WC. Distinct localization of collagenase and TIMP expression in wound healing associated with ulcerative pyogenic granuloma. J Clin Invest 1992; 90: 1952-7.
21. Airola K, Vaalamo M, Reunala T, Saarialho-Kere UK. Enhanced expression of interstitial collagenase. stromelysin-1, and urokinase plasminogen activator in lesions of dermatitis herpetiformis. J Invest Dermatol 1995; 105: 184-9.
22. Saarialho-Kere UK, Chang ES, Welgus HG, Parks WC. Expression of interstitial collagenase. 92kDa gelatinase, and TIMP-1 in granuloma annulare and necrobiosis lipoidica diabeticorum. J Invest Dermatol 1993; 100: 335-42.
23. Saarialho-Kere UK, Crouch EC, Parks WC. The matrix metalloproteinase matrilysin is constitutively expressed in adult human exocrine epithelium. J Invest Dermatol 1995; 105: 190-6.
24. Stricklin GP, Liying L, Jancic V et al. Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds. Am J Pathol 1993; 143: 1657-66.
25. Herrick SE, Sloan P, McGurk M et al. Sequential changes in histologic pattern and extracellular matrix deposition during the healing of chronic venous ulcers. Am J Pathol 1992; 141: 1085-95.
26. Inoue M, Kratz G, Haegerstrand A, Ståhle-Bäckdahl M. Collagenase expression is rapidly induced in wound-edge keratinocytes after acute injury in human skin, persists during healing, and stops at re-epithelialization. J Invest Dermatol 1995; 104: 479-83.
27. Stricklin GP, Nanney LB. Immunolocalization of collagenase and TIMP in healing human burn wounds. J Invest Dermatol 1994; 103: 488-92.
28. Ágren GS, Taplin CJ, Woessner JF et al. Collagenase in wound healing: Effect of wound age and type. J Invest Dermatol 1992; 99: 709-14.
29. Sudbeck BS, Parks WC, Welgus HG, Pentland AP. Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem 1994; 269: 30022-9.
30. Petersen MJ, Woodley DT, Stricklin GP, O'Keefe EJ. Enhanced synthesis of collagenase by human keratinocytes cultured on type I or type IV collagen. J Invest Dermatol 1990; 94: 341-6.
31. Young P, Grinnell F. Metalloproteinase activation cascade after burn injury: A longitudinal analysis of the human wound environment. J Invest Dermatol 1994; 103: 660-4.
32. Bullen EC, Longmaker MT, Updike DL et al. Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases increased in chronic wounds. J Invest Dermatol 1995; 104: 236-40.
33. Romer J, Lund LR, Eriksen J et al. Differential expression of urokinase-type plasminogen activator and its type-1 inhibitor during healing of mouse skin wounds. J Invest Dermatol 1991; 97: 803-11.
34. Grondahl-Hansen J, Lund LR, Ralfkiaer E et al. Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepitheliziation in vivo. J Invest Dermatol 1988; 90: 790-5.
35. Stacey MC, Burnand KG, Mahmoud-Alexandri M et al. Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers. Br J Surg 1993; 80: 596-9.
36. Szabo I, Simon M, Hunyadi J. Modulation of keratinocyte activation process by plasmin. J Invest Dermatol 1994; 103: 431 (Abstr.).
37. Tsuboi R, Sato C, Kurita Y et al. Keratinocyte growth factor (FGF-7) stimulates migration and plasminogen activator activity of normal human keratinocytes. J Invest Dermatol 1993; 101: 49-53.
38. Kovacs SO, Dunsmore S, Rubin JS et al. HGF/SF, a dermally derived growth factor stimulates keratinocyte metalloproteinase production. J Invest Dermatol 1995; 104: 581 (Abstr.).