Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat

Diabetes Care

Volumn 30, Issue 10, 2007, Pages 2673-2678

  Wallace, Tara M ^a   Utzschneider, Kristina M ^a   Tong, Jenny ^a   Carr, Darcy B ^b   Zraika, Sakeneh ^a   Bankson, Daniel D ^a   Knopp, Robert H ^c   Kahn, Steven E ^a,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; LIVER ENZYME;

ABDOMINAL FAT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME BLOOD LEVEL; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MULTIPLE REGRESSION; NORMAL HUMAN; OBESITY; SEX DIFFERENCE; SUBCUTANEOUS FAT;

ADIPOSE TISSUE; ADULT; AGED; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; REFERENCE VALUES;

EID: 35148879567     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc06-1758     Document Type: Article

References (35)

1. Browning JD, Horton JD: Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114:147-152, 2004
2. Hilden M, Christoffersen P, Juhl E, Dalgaard JB: Liver histology in a 'normal' population - examinations of 503 consecutive fatal traffic casualties. Scand J Gastroenterol 12:593-597, 1977
3. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH: Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40:1387-1395, 2004
4. Utzschneider KM, Kahn SE: Review: The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 91:4753-4761, 2006
5. Daniel S, Ben-Menachem T, Vasudevan G, Ma CK, Blumenkehl M: Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 94:3010-3014, 1999
6. Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr, Kempf J, Zinman B, Haffner SM: Elevations in markers of liver injury and risk of type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetes 53:2623-2632, 2004
7. Perry IJ, Wannamethee SG, Shaper AG: Prospective study of serum γ-glutamyltransferase and risk of NIDDM. Diabetes Care 21:732-737, 1998
8. Nakanishi N, Nishina K, Li W, Sato M, Suzuki K, Tatara K: Serum γ-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men. J Intern Med 254:287-295, 2003
9. Lee DH, Silventoinen K, Jacobs DR Jr, Jousilahti P, Tuomileto J: γ-Glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women. J Clin Endocrinol Metab 89:5410-5414, 2004
10. Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M: γ-Glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem 49:1358-1366, 2003
11. Wannamethee G, Ebrahim S, Shaper AG: γ-Glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 142:699-708, 1995
12. Kissebah AH: Intra-abdominal fat: is it a major factor in developing diabetes and coronary artery disease? Diabetes Res Clin Pract 30:25-30, 1996
13. Knopp RH, Retzlaff B, Fish B, Walden C, Wallick S, Anderson M, Aikawa K, Kahn SE: Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding. Arterioscler Thromb Vasc Biol 23:1437-1443, 2003
14. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D Jr: Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993
15. Shuman WP, Morris LL, Leonetti DL, Wahl PW, Moceri VM, Moss AA, Fujimoto WY: Abnormal body fat distribution detected by computed tomography in diabetic men. Invest Radiol 21:483-487, 1986
16. Bergman R, Ider Y, Bowden C, Cobelli C: Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677, 1979
17. Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE: The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes 51:1005-1015, 2002
18. Despres JP, Lemieux I: Abdominal obesity and metabolic syndrome.Nature444:881-887, 2006
19. Nilssen O, Forde OH, Brenn T: The Tromso Study: distribution and population determinants of γ-glutamyltransferase. Am J Epidemiol 132:318-326, 1990
20. Machado M, Cortez-Pinto H: Non-alcoholic fatty liver disease and insulin resistance. Eur J Gastroenterol Hepatol 17:823-826, 2005
21. Thamer C, Tschritter O, Haap M, Shirkavand F, Machann J, Fritsche A, Schick F, Haring H, Stumvoll M: Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids. Horm Metab Res 37:246-251, 2005
22. Schindhelm RK, Diamant M, Bakker SJ, van Dijk RA, Scheffer PG, Teerlink T, Kostense PJ, Heine RJ: Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus. Eur J Clin Invest 35:369-374, 2005
23. Sattar N, Scherbakova O, Ford I, O'Reilly DS, Stanley A, Forrest E, Macfarlane PW, Packard CJ, Cobbe SM, Shepherd J: Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study. Diabetes 53:2855-2860, 2004
24. Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM, Stern MP, Ferrannini E: Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City Diabetes Study. Diabetes Care 28:1757-1762, 2005
25. Vozarova B, Stefan N, Lindsay RS, Saremi A, Pratley RE, Bogardus C, Tataranni PA: High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51:1889-1895, 2002
26. Lee DH, Ha MH, Kim JH, Christiani DC, Gross MD, Steffes M, Blomhoff R, Jacobs DR Jr: γ-Glutamyltransferase and diabetes - a 4 year follow-up study. Diabetologia 46:359-364, 2003
27. Andre P, Balkau B, Born C, Royer B, Wilpart E, Charles MA, Eschwege E: Hepatic markers and development of type 2 diabetes in middle aged men and women: a three-year follow-up study: the D.E.S.I.R. Study (Data from an Epidemiological Study on the Insulin Resistance Syndrome). Diabetes Metab 31:542-550, 2005
28. Pastore A, Federici G, Bertini E, Piemonte F: Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333:19-39, 2003
29. Karp DR, Shimooku K, Lipsky PE: Expression of γ-glutamyl transpeptidase protects Ramos B cells from oxidation-induced cell death. J Biol Chem 276:3798-3804, 2001
30. Lee DH, Jacobs DR Jr: Association between serum γ- glutamyltransferase and C-reactive protein. Atherosclerosis 178:327-330, 2005
31. Westerbacka J, Corner A, Tiikkainen M, Tamminen M, Vehkavaara S, Hakkinen AM, Fredriksson J, Yki-Jarvinen H: Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 47:1360-1369, 2004
32. Promrat K, Lutchman G, Uwaifo GI, Freedman RJ, Soza A, Heller T, Doo E, Ghany M, Premkumar A, Park Y, Liang TJ, Yanovski JA, Kleiner DE, Hoofnagle JH: A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology 39:188-196, 2004
33. Siest G, Schiele F, Galteau MM, Panek E, Steinmetz J, Fagnani F, Gueguen R: Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values. Clin Chem 21:1077-1087, 1975
34. Williams KM, Williams AE, Kline LM, Dodd RY: Stability of serum alanine aminotransferase activity. Transfusion 27:431-433, 1987
35. Clark JM, Brancati FL, Diehl AM: The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98:960-967, 2003