Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: The HEART2D trial

Diabetes Care

Volumn 32, Issue 3, 2009, Pages 381-386

  Raz, Itamar ^a   Jermendy, György ^g   Wilson, Peter W F ^b   Campaigne, Barbara N ^h   Strojek, Krzysztof ^c   Kerr, Lisa ^h   Kowalska, Irina ^d   Milicevic, Zvonko ^h   Bozikov, Velimir ^e   Jacober, Scott J ^h   Gitt, Anselm K ^f  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b EMORY UNIVERSITY   (United States)

^c MEDICAL UNIVERSITY OF SILESIA   (Poland)

^d MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^e University of Zagreb School of Medicine   (Croatia)

^f KLINIKUM LUDWIGSHAFEN   (Germany)

^g BAJCSY ZSILINSZKY HOSPITAL   (Hungary)

^h ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; HUMAN INSULIN; INSULIN GLARGINE; INSULIN LISPRO; ISOPHANE INSULIN; METFORMIN; SULFONYLUREA DERIVATIVE;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; BEDTIME DOSAGE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC PATIENT; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PERIPHERAL EDEMA; PNEUMONIA; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; RISK ASSESSMENT; SEPSIS; THORAX PAIN;

ADULT; AGED; BODY WEIGHT; CARDIOVASCULAR SYSTEM; DIABETES MELLITUS, TYPE 2; DRUG ADMINISTRATION SCHEDULE; FASTING; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; RISK FACTORS; TREATMENT OUTCOME;

EID: 64749114318     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc08-1671     Document Type: Article

References (25)

1. Stamler J, Vaccaro O, Neaton JD, et al: Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16:434-444, 1993
2. Haffner SM, Lehto S, Ronnemaa T, et al: Mortality from coronary heart disease in subjects with type 2 diabetes and in non-diabetic subjects with and without prior myocardial infarction. N Engl J Med 339: 229-234, 1998
3. Eberly LE, Cohen JD, Prineas R, et al: Impact of diabetes and incident nonfatal cardiovascular disease on 18-year mortality. Diabetes Care 26:848-854, 2003
4. Stratton IM, Adler AI, Neil HA, et al: Association of glycaemia with macro-vascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321:405-412,2000
5. Holman RR, Paul SK, Bethel MA, et al.: 10-Year follow-up of intensive glucose control in type 2 diabetes. N Engl] Med 359:1577-1589,2008
6. Beckman JA, Creager MA, Libby P: Diabetes and atherosclerosis: epidemiology, pathophysiology and management. JAMA 287:2570-2581, 2002
7. Lakka HM, Laaksonen DE, Lakka TA, et al.: Metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709-2716, 2002
8. DECODE: Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med 161:397-405, 2001
9. Meigs JB, Nathan DM, D'Agostino RB Sr, et al.: Fasting and postchallenge glycemia and cardiovascular disease risk: the Fra-mingham Offspring Study. Diabetes Care 25:1845-1850, 2002
10. Ceriello A: Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54:1-7, 2005
11. Chiasson JL, Josse RG, Gomis R, et al.: Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290:486-494, 2003
12. Malmberg K: Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes melli-tus: DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ 314:1512-1515,1997
13. Milicevic Z, Raz I, Strojek K, et al.: Hyperglycemia and its effect after acute myocardial infarction on cardiovascular outcomes in patients with type 2 diabetes mellitus (HEART2D) study design. J Diabetes Complications 19:80-87, 2005
14. Esposito K, Giugliamo D, Nappo F, et al.: Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus. Circulation 110:214-219, 2004
15. Shimabukuro M, Chinen I, Higa N, et al.: Effects of dietary composition on postprandial endothelial function and adi- ponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr 86:923-928, 2007
16. Mita T, Watada H, Shimizu T, et al.: Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control. Arterioscler Thromb Vasc Biol 27:2456-2462, 2007
17. Alssema M, Schindhelm RK, Dekker JM, et al: Postprandial glucose and not tri-glyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study. Atherosclerosis 196:712-719, 2008
18. Dormandy JA, Charbonnel B, Eckland DJ, et al.: Secondary prevention of macrovas-cular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglit Azone Clinical Trial In macro-Vascular Events): a randomised controlled trial. Lancet 366:1279-1289, 2005
19. Malmberg K, Ryden L, Wedel H, et al: Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 26:650-661, 2005
20. Van den Berghe G: Insulin vs. strict blood glucose control to achieve a survival benefit after AMI? Eur Heart J 26:639-641, 2005
21. The Action to Control Cardiovascular Risk in Diabetes Study Group: Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545-2559, 2008
22. The ADVANCE Collaborative Group: Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358:2560-2572, 2008
23. Duckworth W, Abraira C, Moritz T, et al.: Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360:129-139, 2009
24. Juutilainen A, Lehto S, Rönnemaa T, et al.: Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects. Diabetes Care 31: 714-719, 2008
25. Ceriello A, Assaloni R, Da Ros R, et al: Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation 111:2518-2524, 2005