Insulin vs. strict blood glucose control to achieve a survival benefit after AMI?

European Heart Journal

Volumn 26, Issue 7, 2005, Pages 639-641

  Van Den Berghe, G ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; POTASSIUM;

ACUTE HEART INFARCTION; BLOOD GLUCOSE MONITORING; EDITORIAL; GLYCOLYSIS; HEART PROTECTION; HUMAN; INSULIN TREATMENT; MORBIDITY; MORTALITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SURVIVAL RATE;

BLOOD GLUCOSE; DIABETIC ANGIOPATHIES; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MYOCARDIAL INFARCTION; SURVIVAL ANALYSIS;

EID: 17144378559     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1093/eurheartj/ehi232     Document Type: Editorial

References (10)

1. Sodi-Pallares D, Testelli MR, Fishleder B. Effects of an intravenous infusion of a potassium-insulin-glucose solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol 1962;9:166-181.
2. Opie L. The glucose hypothesis: relation to acute myocardial ischemia. J Mol Cell Cardiol 1970;1:107-114.
3. Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P, Waldenstrom A, Wedel H, Welin L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995;26:57-65.
4. Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, Macleod K, Laakso M, Torp-Pedersen C, Waldenström A for the DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on morbidity and mortality. Eur Heart J 2005;26:650-661. First published on February 23, 2005, doi:10.1093/eurheartj/ehi199.
5. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345: 1359-1367.
6. Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003;31:359-366.
7. Vanhorebeek I, De Vos R, Mesotten M, Wouters PJ, De Wolf-Peeters C, Van den Berghe G. Strict blood glucose control with insulin in critically ill patients protects hepatocytic mitochondrial ultrastructure and function. Lancet 2005;365:53-59.
8. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care? J Clin Invest 2004;114: 1187-1195.
9. Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe G. Intensive insulin therapy exerts anti-inflammatory effects in critically ill patients, as indicated by circulating mannan-binding lectin and C-reactive protein levels. J Clin Endocrinol Metab 2003;88:1082-1088.
10. Mesotten D, Swinnen J, Vanderhoydonc F, Wouters PJ, Van den Berghe G. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 2004;89:219-226.