Hepatitis C virus and its complex interplay with hepatic glucose and lipid metabolism

Journal of Hepatology

Volumn 50, Issue 5, 2009, Pages 845-847

  Bartosch, Birke ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ LYON 1   (France)

^c HÔTEL DIEU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; LIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; VERY LOW DENSITY LIPOPROTEIN;

DOWN REGULATION; EDITORIAL; GENOTYPE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER BIOPSY; LIVER CELL CULTURE; PRIORITY JOURNAL; REPLICON; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; VIRUS REPLICATION;

GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 2; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIPID METABOLISM; LIVER; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

EID: 64749093727     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.02.009     Document Type: Editorial

References (30)

1. Alter M.J. Epidemiology of hepatitis C virus infection. World J Gastroenterol 13 (2007) 2436-2441
2. Fartoux L., Poujol-Robert A., Guechot J., Wendum D., Poupon R., Serfaty L., et al. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 54 (2005) 1003-1008
3. Hui J.M., Sud A., Farrell G.C., Bandara P., Byth K., Kench J.G., et al. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]. Gastroenterology 125 (2003) 1695-1704
4. Moucari R., Asselah T., Cazals-Hatem D., Voitot H., Boyer N., Ripault M.P., et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology 134 (2008) 416-423
5. Shintani Y., Fujie H., Miyoshi H., Tsutsumi T., Tsukamoto K., Kimura S., et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 126 (2004) 840-848
6. Bernsmeier C., Duong F.H., Christen V., Pugnale P., Negro F., Terracciano L., et al. Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. J Hepatol 49 (2008) 429-440
7. Duong F.H., Christen V., Berke J.M., Penna S.H., Moradpour D., and Heim M.H. Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. J Virol 79 (2005) 15342-15350
8. Kasai D., Adachi T., Deng L., Nagano-Fujii M., Sada K., Ikeda M., et al. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters. J Hepatol 50 (2009) 883-894
9. Zhao F.Q., and Keating A.F. Functional properties and genomics of glucose transporters. Curr Genomics 8 (2007) 113-128
10. Mueckler M., Hresko R.C., and Sato M. Structure, function and biosynthesis of GLUT1. Biochem Soc Trans 25 (1997) 951-954
11. Wright E.M., and Turk E. The sodium/glucose cotransport family SLC5. Pflugers Arch 447 (2004) 510-518
12. Kellett G.L., and Brot-Laroche E. Apical GLUT2: a major pathway of intestinal sugar absorption. Diabetes 54 (2005) 3056-3062
13. Guillam M.T., Hummler E., Schaerer E., Yeh J.I., Birnbaum M.J., Beermann F., et al. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet 17 (1997) 327-330
14. Bady I., Marty N., Dallaporta M., Emery M., Gyger J., Tarussio D., et al. Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes 55 (2006) 988-995
15. Uldry M., Ibberson M., Hosokawa M., and Thorens B. GLUT2 is a high affinity glucosamine transporter. FEBS Lett 524 (2002) 199-203
16. Guillam M.T., Burcelin R., and Thorens B. Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes. Proc Natl Acad Sci USA 95 (1998) 12317-12321
17. Hosokawa M., and Thorens B. Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. Am J Physiol Endocrinol Metab 282 (2002) E794-E801
18. Yang W., Hood B.L., Chadwick S.L., Liu S., Watkins S.C., Luo G., et al. Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production. Hepatology 48 (2008) 1396-1403
19. Jackel-Cram C., Babiuk L.A., and Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol 46 (2007) 999-1008
20. Oem J.K., Jackel-Cram C., Li Y.P., Zhou Y., Zhong J., Shimano H., et al. Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. J Gen Virol 89 (2008) 1225-1230
21. Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas M., et al. The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 9 (2007) 1089-1097
22. Moradpour D., Penin F., and Rice C.M. Replication of hepatitis C virus. Nat Rev Microbiol 5 (2007) 453-463
23. Dentin R., Girard J., and Postic C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 87 (2005) 81-86
24. Denechaud P.D., Dentin R., Girard J., and Postic C. Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett 582 (2008) 68-73
25. Dentin R., Pegorier J.P., Benhamed F., Foufelle F., Ferre P., Fauveau V., et al. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279 (2004) 20314-20326
26. Davies M.N., O'Callaghan B.L., and Towle H.C. Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity. J Biol Chem 283 (2008) 24029-24038
27. Iizuka K., and Horikawa Y. ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome. Endocr J 55 (2008) 617-624
28. Borowski P., Heiland M., Oehlmann K., Becker B., Kornetzky L., Feucht H., et al. Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase. Eur J Biochem 237 (1996) 611-618
29. Aoubala M., Holt J., Clegg R.A., Rowlands D.J., and Harris M. The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis. J Gen Virol 82 (2001) 1637-1646
30. Eisenberg M.L., Maker A.V., Slezak L.A., Nathan J.D., Sritharan K.C., Jena B.P., et al. Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Cell Physiol Biochem 15 (2005) 51-58