A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

Antiviral Research

Volumn 82, Issue 3, 2009, Pages 141-147

  Paeshuyse, Jan ^a   Letellier, Carine ^b   Froeyen, Matheus ^a   Dutartre, Hélène ^c   Vrancken, Robert ^b   Canard, Bruno ^c   De Clercq, Erik ^a   Gueiffier, Alain ^g   Teulade, Jean Claude ^f   Herdewijn, Piet ^a   Puerstinger, Gerhard ^e   Koenen, Frank ^b   Kerkhofs, Pierre ^b   Baraldi, Pier Giovanni ^d   Neyts, Johan ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b VETERINARY AND AGROCHEMICAL RESEARCH CENTRE   (Belgium)

^c Centre National de la Recherche Scientifique   (France)

^d UNIVERSITY OF FERRARA   (Italy)

^e UNIVERSITY OF INNSBRUCK   (Austria)

^f UNIVERSITÉ DE TOURS   (France)

^g UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Bovine viral diarrhea virus; Inhibitor; Pyrazolotriazolopyrimidinamine; RNA dependent RNA polymerase

Indexed keywords

5 [(4 BROMOPHENYL)METHYL] 2 PHENYL 5H IMIDAZO[4,5 C]PYRIDINE; 7 [3 (1,3 BENZODIOXOL 5 YL)PROPYL] 2 (2 FURYL) 7H PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 AMINE; AG 110; ANTIVIRUS AGENT; CARBOXYLIC ACID DERIVATIVE; ETHYL 2 METHYLIMIDAZO[1,2 A]PYRROLO[2,3 C]PYRIDIN 8 CARBOXYLATE; IMIDAZOPYRIDINE DERIVATIVE; LZ 37; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; BOVINE DIARRHEA VIRUS; CONTROLLED STUDY; COW; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG TARGETING; HEPATITIS C VIRUS; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA SYNTHESIS; VIRUS MUTATION; VIRUS RECOMBINANT; VIRUS REPLICATION; YELLOW FEVER FLAVIVIRUS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIVIRAL AGENTS; BENZODIOXOLES; CATTLE; CELL LINE; DIARRHEA VIRUS 1, BOVINE VIRAL; DIARRHEA VIRUS 2, BOVINE VIRAL; DRUG RESISTANCE, VIRAL; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MUTATION, MISSENSE; RNA REPLICASE; TRIAZOLES; VIRAL PROTEINS; VIRUS REPLICATION; YELLOW FEVER VIRUS;

BOVINE VIRAL DIARRHEA VIRUS 1; FLAVIVIRUS; HEPATITIS C VIRUS; HUMAN ECHOVIRUS 1; PESTIVIRUS;

EID: 64749086152     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.02.192     Document Type: Article

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