Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan

Journal of Pineal Research

Volumn 46, Issue 4, 2009, Pages 408-414

  Celinski, K ^a   Konturek, P C ^b   Slomka, M ^a   Cichoz Lach, H ^a   Gonciarz, M ^c   Bielanski, W ^c   Reiter, R J ^d   Konturek, S J ^c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d University of Texas Health Science Center at San Antonio   (United States)

Author keywords

Gastrin; Ghrelin; Liver cirrhosis; Melatonin; Portal hypertension

Indexed keywords

GASTRIN; GHRELIN; INSULIN; LEPTIN; MELATONIN; TRYPTOPHAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; GASTRIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIVER CIRRHOSIS; MALE; PORTAL HYPERTENSION; POSTPRANDIAL STATE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; BASAL METABOLISM; CASE-CONTROL STUDIES; DATA INTERPRETATION, STATISTICAL; GASTRINS; GHRELIN; HUMANS; HYPERTENSION, PORTAL; INSULIN; LEPTIN; LIVER CIRRHOSIS; MALE; MELATONIN; PEPTIDE HORMONES; POSTPRANDIAL PERIOD; TRYPTOPHAN;

EID: 64649106141     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2009.00677.x     Document Type: Article

References (53)

1. Kalaitzakis E, Bosaeus I, Ohman L et al. Altered postprandial glucose, insulin, leptin and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditure. Am J Clin Nutr 2007 85 : 808 815.
2. Bosch J. Vascular deterioration in cirrhosis. The big picture. J Clin Gastroenterol 2007 41 (Suppl. 3 S247 S253.
3. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, resistin. Clin Chem 2004 50 : 1511 1525.
4. Marchesini G, Bianchi G, Lucidi P et al. Plasma ghrelin concentration, food intake, and anorexia in liver failure. J Endocrinol Metab 2004 89 : 2136 2141.
5. Ockenga J, Bichoff SC, Tillmannn HL et al. Elevated bound leptin correlates with energy expenditure in cirrhotics. Gastroenterology 2001 119 : 1656 1662.
6. McCullough AJ, Bugianesi E, Marchesini G et al. Gender-dependent alterations in serum leptin in alcoholic cirrhosis. Gastroenterology 1998 115 : 947 953.
7. Lin SY, Wang YY, Sheu HH. Increased serum leptin concentrations correlate with soluble tumor necrosis factor receptor levels in patients with cirrhosis. Clin Endocrinol 2002 57 : 805 811.
8. Testa R, Franceschini R, Giannini E et al. Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis. J Hepatol 2000 33 : 33 37.
9. Ben-Ari Z, Schafer Z, Sulkes J et al. Alterations in serum leptin inn chronic liver disease. Dig Dis Sci 2002 47 : 183 189.
10. Campillo B, Sherman E, Richardet JP et al. Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. Eur J Clin Nutr 2001 55 : 2923 2927.
11. Tacke F, Brabant G, Kruck E et al. Ghrelin in chronic liver disease. J Hepatol 2003 38 : 447 454.
12. Murdolo G, Lucidi P, Diloreto C et al. Insulin is required for prandial ghrelin suppression in humans. Diabetes 2003 52 : 2923 2927.
13. Flanagan DE, Evans ML, Monsod TP et al. The influence of insulin on circulating ghrelin. Am J Endocrinol Metab 2003 284 : E313 E316.
14. Blom WAS, Stafleu A, deGraaf C et al. Ghrelin response to carbohydrate-enriched breakfast is related to insulin. Am J Clin Nutr 2005 81 : 367 375.
15. Saad MF, Khan A, Sharma A et al. Physiological insulinemia acutely modulates plasma leptin. Diabetes 1998 47 : 544 549.
16. Erdmann J, Lippl F, Wagenpfeil S et al. Differential association of basal and postprandial plasma ghrelin with leptin, insulin and type 2 diabetes. Diabetes 2005 54 : 1371 1378.
17. Bubenik G. Thirty four years since the discovery of the gastrointestinal melatonin. J Physiol Pharmacol 2008 59 (Suppl. 2 33 51.
18. Konturek SJ, Konturek PC, Brzozowsli T et al. Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT). J Physiol Pharmacol 2007 58 : 381 405.
19. Konturek SJ, Brzozowki T, Konturek PC et al. Brain-Gut and appetite regulating hormones in the control of gastric secretion and mucosal protection. J Physiol Pharmacol 2008 59 (Suppl. 2 7 31.
20. Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology 2008 134 : 1842 1860.
21. Iguchi H, Kato KI, Ibayashi H. Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis. J Clin Endocrinol Metab 1982 54 : 1025 1027.
22. Lanea EA, Moss HB. Pharmacokinetics of melatonin in man: first pass hepatic Metabolism. J Clin Endocrinol Metab 1985 61 : 1214 1216.
23. Steindl PE, Finn B, Bendok B et al. Changes in the 24-hour rhythm of plasma melatonin in patients with liver cirrhosis - relation to sleep architecture. Wien Klin Wochenschr 1997 109 : 741 746.
24. Ardizzi A, Grugni G, Saglietti G et al. Circadian rhythm of melatonin in liver cirrhosis. Minerva Med 1998 89 : 1 4.
25. Pardridge WM, Mietus RJ. Transport of albumin-bound melatonin through the blood-brain barrier. J Neurochem 1980 34 : 1761 1763.
26. Cordoba J, Cabera J, Latif L et al. High prevalence of sleep disturbances in cirrhosis. Hepatology 1998 27 : 339 345.
27. Wang H, Wei W, Wang NP et al. Melatonin ameliorates carbonic tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life Sci 2005 77 : 1902 1915.
28. Cruz A, Padillo FJ, Torres E et al. Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats. J Pineal Res 2005 39 : 143 150.
29. Pan M, Song YL, Xu JM et al. Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats. J Pineal Res 2006 41 : 79 84.
30. Koppisetti S, Jenigiri B, Terron MP et al. Reactive oxygen species and the hypomotility of the gallbladder as targets for the treatment of gall stones with melatonin: a review. Dig Dis Sci 2008 53 : 2592 2603.
31. Tan DX, Manchhester LC, Reiter RJ et al. High physiological levels of melatonin in the bile of mammals. Life Sci 1999 65 : 2523 2529.
32. Wang F, Leng X, Du R. The level of serum gastrin and ulceration in cirrhotic patients with portal hypertension. Zhonghua Wai Ke Za Zhi, 1955 33 : 351 352.
33. Konturek SJ, Gonciarz M, Gonciarz Z et al. Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. Scand J Gastroenterol 2003 38 : 643 647.
34. Peyen JL, Cales P, Voigt JJ et al. Severe portal hypertensive gastropathy and antral vascular ectasia are distinct entities in patients with cirrhosis. Gastroenterology 1995 109 : 138 144.
35. Avgerinos A, Dimitrou-Youdri Y, Adamopoulos A et al. Urinary gastrin output and serum gastrin in patients with liver cirrhosis. Urinary gastrin output in cirrhosis. Hepatogastroenterology 1994 41 : 445 448.
36. Lenz HJ, Struck T, Greten H et al. Increased sensitivity of gastric acid secretion to gastrin in cirrhotic patients with portocaval shunt. J Clin Invest 1987 79 : 1120 1124.
37. Petersen B, Henriksen JH, Rehfeld JF et al. Removal of endogenous gastrin in man. Scand J Gastroenterol 1981 16 : 727 730.
38. Bosch J, Gomis R, Kravetz D et al. Role of spontaneous porto-systemic shunting in hyperinsulinism of cirrhosis. Am J Physiol 1984 247 : G206 G212.
39. Sirinek KR, O'Dorisio TM, Levine BA. Glucose intolerance and hyperinsulinemia of cirrhosis are not result of spontaneous or surgical portosystemic shunting. Am J Sur 1991 161 : 149 153.
40. Modi GK, Shah P, Acharya SK et al. Portal systemic shunting of insulin does not lead to insulin resistance in patients with extrahepatic portal vein obstruction. Horm Metab Res 1999 31 : 462 466.
41. del Olmo JA, Flor-Lorente B, Flor-Civera F et al. Risk factors for nonhepatic surgery in patients with cirrhosis. World J Surg 2003 27 : 647 652.
42. Suman A, Barbess DS, Zein NN et al. Predicting outcome after cardiac surgery in patients with cirrhosis: a comparison of Child-Pugh and MELD scores. Clin Gastroenterol Hepatol 2004 2 : 719 723.
43. Konturek PC, Konturek SJ, Starzyńska T et al. Helicobacter pylori, gastrin link in MALT lymphoma. Aliment Pharmacol Ther 2000 14 : 1311 1318.
44. Sanyal AJ, Bosch J, Blei A et al. Portal hyepertension and its complications. Gastroenterology 2008 134 : 1715 1728.
45. Waldhauser F, Waldhauser M, Lieberman HR et al. Bioavailability of oral melatonin in humans. Neuroendocrinology 1984 39 : 307 313.
46. Aldhous M, Franey C, Wright J et al. Plasma concentrations of melatonin in man following oral absorption of different preparations. Br J Clin Pharmacol 1985 19 : 517 521.
47. Messner M, Huenter G, Lorf R et al. Presence of melatonin in human hepatobiliary-gastrointestinal tract. Life Sci 2001 69 : 543 551.
48. Raikhlin NT, Kvetnoy IM. Melatonin and enterochromaffin cells. Acta Histochem 1976 55 : 19 24.
49. Huether G, Poeggeller B, Reimer R et al. Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci 1992 51 : 945 953.
50. Bubenik GA, Pang SF, Cokshut JR et al. Circadian variation of portal arterial and venous blood levels of melatonin in pigs and its relationship to food intake and sleep. J Pineal Res 2000 28 : 9 15.
51. Konturek PC, Konturek SJ, Burnat G et al. Dynamic physiological and molecular changes in gastric ulcer healing achieved by melatonin and its precursor l-tryptophan in rats. J Pineal Res 2008 45 : 180 190.
52. Tan DX, Manchester LC, Terron MP et al. One molecule many derivatives; a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 : 28 42.
53. Peyrot F, Ducrocq C. Potential of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 2008 45 : 235 246.