Reactive oxygen species and the hypomotility of the gall bladder as targets for the treatment of gallstones with melatonin: A review

Digestive Diseases and Sciences

Volumn 53, Issue 10, 2008, Pages 2592-2603

  Koppisetti, Sreedevi ^a   Jenigiri, Bharat ^b   Terron, M Pilar ^a   Tengattini, Sandra ^a   Tamura, Hiroshi ^a   Flores, Luis J ^a   Tan, Dun Xian ^a   Reiter, Russel J ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Antioxidant; Cholelithiasis; Gallstones; Melatonin

Indexed keywords

ACETYLSALICYLIC ACID; ANTIOXIDANT; CELECOXIB; LARREA TRIDENTATA EXTRACT; MELATONIN; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

CHOLECYSTECTOMY; CHOLELITHIASIS; DRUG MECHANISM; GALLBLADDER; GALLSTONE; HUMAN; HYPERCHOLESTEROLEMIA; INCIDENCE; LARREA; NONHUMAN; OBESITY; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; RISK FACTOR;

ANTIOXIDANTS; CHOLELITHIASIS; CHOLESTEROL; GALLBLADDER EMPTYING; GALLSTONES; HUMANS; MELATONIN; REACTIVE OXYGEN SPECIES;

EID: 50949127067     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-0195-5     Document Type: Review

References (145)

1. WH Shehadi 1979 The biliary system through the ages Int Surg 64 63 78
2. National Institutes of Health Consensus Development Conference Statement on Gallstones and Laparoscopic Cholecystectomy. Am J Surg 165:390-396, 1993
3. CE Cross B Halliwell ET Borish WA Pryor BN Ames RL Saul JM McCord D Harman 1987 Oxygen radicals and human disease Ann Intern Med 107 526 545
4. Ahmed A, Cheung RC, Keefe EB (2000) Management of gallstones and their complications. Am Fam Physician 61:1673-1680, 1687-1688
5. SG Corradini W Elisei L Giovannelli C Ripani P Della Guardia A Corsi A Cantafora L Capocaccia V Ziparo V Stipa P Chirletti D Lomanto AF Attili 2000 Impaired human gallbladder lipid absorption in cholesterol gallstone disease and its effect on cholesterol solubility in bile Gastroenterology 118 912 920
6. FX Caroli-Bosc C Deveau EP Peten B Delabre H Zanaldi X Hebuterne P Hastier F Viudes F Belanger C Caroli-Bosc A Harris M Hardion P Rampal JP Delmont 1998 Cholelithiasis and dietary risk factors (an epidemiologic investigation in Vidauban, Southeast France) Dig Dis Sci 43 2131 2137
7. RT Holzbach M Marsh M Olszewski K Holan 1973 Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man J Clin Invest 52 1467 1479
8. M Jirsa AK Groen 2001 Role of biliary proteins and non-protein factors in kinetics of cholesterol crystallisation and gallstone growth Front Biosci 6 154 167
9. P Portincasa A Di Ciaula G Baldassarre V Palmieri A Gentile A Cimmino G Palasciano 1994 Gallbladder motor function in gallstone patients: sonographic and in vitro studies on the role of gallstones, smooth muscle function and gallbladder wall inflammation J Hepatol 21 430 440
10. N Hoogerbrugge-vd Linden FW de Rooy H Jansen M van Blankenstein 1990 Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia Gut 31 348 350
11. WW LaMorte EA Brotschi TE Scott LF Williams Jr 1985 Pigment gallstone formation in the cholesterol-fed guinea pig Hepatology 5 21 27
12. SA Hussain 2007 Effect of melatonin on cholesterol absorption in rats J Pineal Res 42 267 271
13. TY Chan PL Tang 1995 Effect of melatonin on the maintenance of cholesterol homeostasis in the rat Endocr Res 21 681 696
14. SA Hussain KI Hussein BN Saieed 2004 Improvement of the hypolipidemic effect of lovastatin with melatonin Iraqi Postgrad Med J 3 343 346
15. HM Al-Mahabashy SA Hussain NM Numan 2006 The effects of melatonin on the oxidative stress, protein glycation, microalbuminuria and lipid profile in type 2 diabetes mellitus Iraqi J Pharm Sci 15 27 32
16. SH Ismail SA Hussain NA Numan 2004 Hypolipidemic effect of melatonin in dyslipidemia associated with diabetes Iraqi Postgrad Med J 3 223 226
17. ML Pita M Hoyos I Martin-Lacave C Osuna JM Fernández-Santos JM Guerrero 2002 Long-term melatonin administration increases polyunsaturated fatty acid percentage in plasma lipids of hypercholesterolemic rats J Pineal Res 32 179 186
18. PJ Gomez-Pinilla C Camello-Almaraz R Moreno PJ Camello MJ Pozo 2006 Melatonin treatment reverts age-related changes in guinea pig gallbladder neuromuscular transmission and contractility J Pharmacol Exp Ther 319 847 856
19. S Morales PJ Camello S Alcon GM Salido G Mawe MJ Pozo 2004 Coactivation of capacitative calcium entry and L-type calcium channels in guinea pig gallbladder Am J Physiol Gastrointest Liver Physiol 286 G1090 -G1100
20. S Morales PJ Camello GM Mawe MJ Pozo 2005 Characterization of intracellular Ca2+ stores in gallbladder smooth muscle Am J Physiol Gastrointest Liver Physiol 288 G507 G513
21. KJ van Erpecum GP vanBerge-Henegouwen 1999 Gallstones: an intestinal disease? Gut 44 435 438
22. P Portincasa KJ van Erpecum GP vanBerge-Henegouwen 1997 Cholesterol crystallisation in bile Gut 41 138 141
23. QW Xu EA Shaffer 1996 The potential site of impaired gallbladder contractility in an animal model of cholesterol gallstone disease Gastroenterology 110 251 257
24. BJM van de Heijning P van de Meeberg P Portincasa H Doornewaard FJP Hoebers KJ van Erpecum GP Vanberge-Henegouwen 1999 Effects of ursodeoxycholic acid therapy on in vitro gallbladder contractility in patients with cholesterol gallstones Dig Dis Sci 44 190 196
25. Q Chen J Amaral P Biancani J Behar 1999 Excess membrane cholesterol alters human gallbladder muscle contractility and membrane fluidity Gastroenterology 116 678 685
26. J Jaworek K Nawrot SJ Konturek A Leja-Szpak P Thor WW Pawlik 2004 Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro J Pineal Res 36 155 164
27. D Tan LC Manchester RJ Reiter W Qi MA Hanes NJ Farley 1999 High physiological levels of melatonin in the bile of mammals Life Sci 65 2523 2529
28. M Messner G Huether T Lorf G Ramadori H Schwörer 2001 Presence of melatonin in the human hepatobiliary-gastrointestinal tract Life Sci 69 543 551
29. S Aust T Thalhammer S Humpeler W Jager M Klimpfinger G Tucek P Obrist W Marktl E Penner C Ekmekcioglu 2004 The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia J Pineal Res 36 43 48
30. C Von Gall JH Stehle DR Weaver 2002 Mammalian melatonin receptors: molecular biology and signal transduction Cell Tissue Res 309 151 162
31. KJ van Erpecum NG Venneman P Portincasa GP vanBerge-Henegouwen 2000 Review article: agents affecting gall-bladder motility-role in treatment and prevention of gallstones Aliment Pharmacol Ther 14 66 70
32. XW Chen JT Cai 2003 The impact of selective cycloxygenase-2 inhibitor celecoxib on the formation of cholesterol gallstone Zhonghua Nei Ke Za Zhi 42 797 799
33. JI Kourie 1998 Interaction of reactive oxygen species with ion transport mechanisms Am J Physiol 275 C1 C24
34. SP Lee AJ Scott 1982 The evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterol-cholic acid diet Am J Pathol 108 1 8
35. SP Lee JT Lamont MC Carey 1981 Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones: Studies in the prairie dog J Clin Invest 67 1712 1723
36. AJ Scott 1978 Epithelial cell proliferation in diverse models of experimental cholelithiasis Gut 19 558 562
37. SP Lee AJ Scott 1982 The evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterolcholic acid diet Am J Pathol 108 1 8
38. SP Lee JF Nicholls 1986 Nature and composition of biliary sludge Gastroenterology 90 677 686
39. MJ Burnstein RG Ilson CN Petrunke RD Taylor SM Strasberg 1983 Evidence for a potent nucleating factor in the gallbladder bile of patients with cholesterol stones Gastroenterology 85 801 807
40. IA Bouchier SR Cooperband BM El Kodsi 1965 Mucous substances and viscosity of normal and pathological human bile Gastroenterology 49 343 353
41. SP Lee JT LaMont MC Carey 1981 Role of gallbladder mucin hyper secretion in the evolution of cholesterol gallstones: studies in the prairie dog J Clin Invest 67 1712 1723
42. HJ Kim SK Lee MH Kim DW Seo YI Min 2003 Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder Dig Dis Sci 48 726 732
43. KT Lee TS Liu 2001 Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas Dig Dis Sci 46 2166 2172
44. BJ Van Klinken J Dekker SA Van Gool J Van Marle HA Buller AW Einerhand 1998 MUC5B is the prominent mucin in human gallbladder and is also expressed in a subset of colonic goblet cells Am J Physiol 274 G871 878
45. A Vilkin I Nudelman S Morgenstern A Geller YB Dayan Z Levi G Rodionov B Hardy F Konikoff D Gobbic Y Niv 2007 Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation Dig Dis Sci 52 1613 1620
46. DP Nunes NH Afdhal GD Offner 1999 A recombinant bovine gallbladder mucin polypeptide binds biliary lipids and accelerates cholesterol crystal appearance time Gastroenterology 116 936 942
47. NH Afdhal JD Ostrow R Koehler N Niu AK Groen A Veis DP Nunes GD Offner 1995 Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation Gastroenterology 109 1661 1672
48. JT LaMont BF Smith JR Moore 1984 Role of gallbladder mucin in pathophysiology of gallstones Hepatology 4 51S 56S
49. M Rhodes A Allen RH Dowling G Murphy TW Lennard 1992 Inhibition of human gall bladder mucus synthesis in patients undergoing cholecystectomy Gut 33 1113 1117
50. WC Chapman GA Peterkin 3rd WW LaMorte LF Williams Jr 1989 Alterations in biliary motility correlate with increased gallbladder prostaglandin synthesis in early cholelithiasis in prairie dog Dig Dis Sci 34 1420 1424
51. SB Ho LL Shekels NW Toribara IK Gipson YS Kim PP Purdum 3rd DL Cherwitz 2000 Altered mucin core peptide expression in acute and chronic cholecystitis Dig Dis Sci 45 1061 1071
52. R Jansson G Steen J Svanvik 1978 Effects of intravenous vasoactive intestinal polypeptide (VIP) on gallbladder function in the cat Gastroenterology 75 47 50
53. SC Shiesh CY Chen XZ Lin ZA Liu HC Tsao 2000 Melatonin prevents pigment gallstone formation induced by bile duct ligation in guinea pigs Hepatology 32 455 460
54. JC Mayo RM Sainz DX Tan R Hardeland J Leon C Rodriguez RJ Reiter 2005 Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl- 5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK) in macrophages J Neuroimmunol 165 139 149
55. KK Wu 2005 Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators Prostaglandins Leukot Essent Fatty Acids 72 89 93
56. QW Xie R Whisnant C Nathan 1993 Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide J Exp Med 177 1779 1784
57. CJ Lowenstein EW Alley P Raval AM Snowman SH Snyder SW Russell WJ Murphy 1993 Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide Proc Natl Acad Sci USA 90 9730 9734
58. DJ Wadleigh ST Reddy E Kopp S Ghosh HR Herschman 2000 Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages J Biol Chem 275 6259 6266
59. HR Herschman 1996 Prostaglandin synthase 2 Biochim Biophys Acta 1299 125 140
60. V Dixit TW Mak 2002 NF-kappaB signaling: many roads lead to Madrid Cell 111 615 619
61. RL Conter JL Washington CC Liao GL Kauffman Jr 1992 Gallbladder mucosal blood flow increases during early cholesterol gallstone formation Gastroenterology 102 1764 1770
62. S Nash J Stafford JL Madara 1987 Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers J Clin Invest 80 1104 1113
63. WB Hale B Turner JT Lamont 1987 Oxygen radicals stimulate guinea pig gallbladder glycoprotein secretion in vitro Am J Physiol 253 G627 G630
64. D Lichtenberg S Ragimova Y Peled Z Halpern 1988 Phospholipid peroxidation as a factor in gallstone pathogenesis FEBS Lett 228 179 181
65. KR Holan RT Holzbach RE Hermann AM Cooperman WJ Claffey 1979 Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease Gastroenterology 77 611 617
66. MI Eder JF Miquel D Jungst G Paumagartner C VonRitter 1996 Reactive oxygen metabolites promote cholesterol crystal formation in model bile: role of lipid peroxidation Free Radic Biol Med 20 743 749
67. SJ Weiss 1989 Tissue destruction by neutrophils N Engl J Med 320 365 376
68. MC Carey DM Small 1978 The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man J Clin Invest 61 998 1026
69. H Esterbauer RJ Schaur H Zollner 1991 Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic Biol Med 11 81 128
70. WB Hale B Turner JT LaMont 1987 Oxygen radicals stimulate guinea pig gallbladder glycoprotein secretion in vitro Am J Physiol 235 G627 G630
71. A Geetha 2002 Evidence for oxidative stress in the gall bladder mucosa of gallstone patients J Biochem Mol Biol Biophys 6 427 432
72. RJ Reiter DX Tan LC Manchester MR El Sawi 2002 Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging Ann NY Acad Sci 959 238 250
73. R Hardeland RJ Reiter B Poeggeler DX Tan 1993 The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances Neurosci Biobehav Rev 17 347 357
74. RJ Reiter DX Tan MP Terron LJ Flores Z Czarnocki 2007 Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions Acta Biochim Pol 54 1 9
75. H Ozturk H Öztürk Y Yagmur AK Uzunlar 2006 Effects of melatonin administration on intestinal adaptive response after massive bowel resection in rats Dig Dis Sci 51 333 337
76. D Bilici H Süleyman Z Nur Banoǧlu A Kiziltunç B Avci A Çiftçioǧlu S Bilici 2002 Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect Dig Dis Sci 47 856 861
77. W Qi DX Tan RJ Reiter SJ Kim LC Manchester J Cabrera RM Sainz JC Mayo 1999 Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats Dig Dis Sci 44 2257 2262
78. G Şener-Muratoǧlu K Paskaloǧlu S Arbak C Hürdaǧ G Ayanoǧlu-Dülger 2001 Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats Dig Dis Sci 46 318 330
79. G Sener FO Goren NB Ulusoy Y Ersoy S Arbak GA Dólger 2005 Protective effect of melatonin and omeprazole against alendronat-induced gastric damage Dig Dis Sci 50 1506 1512
80. GA Bubenik 2002 Gastrointestinal melatonin: localization, function, and clinical relevance Dig Dis Sci 47 2336 2348
81. G Contuk F Ercan S Çetinel E Çikler G Sener 2005 Role of melatonin in reducing water avoidance stress-induced degeneration of the liver Dig Dis Sci 50 738 744
82. HV Worthington LP Hunt RF McCloy JB Ubbink JM Braganza 1997 A pilot study of antioxidant intake in patients with cholesterol gallstones Nutrition 13 118 127
83. C Lin T Shen X Fu X Zhou 1996 The ability of bile to scavenge superoxide radicals and pigment gallstone formation in guinea pigs HPB Surg 10 73 76
84. EA Vagner VV Khlebnikov NA Terekhina LF Palatova 1997 Antioxidants in the treatment of cholelithiasis patients Vestn Khir Im II Grek 156 36 39
85. DX Tan B Poeggeler RJ Reiter LD Chen S Chen LC Manchester LR Barlow-Walden 1993 The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo Cancer Lett 70 65 71
86. S Arteaga A Carmona J Luis A Andrade-Cetto R Cárdenas 2005 Effect of Larrea tridentata (creosote bush) on cholesterol gallstones and bile secretion in hamsters J Pharm Pharmacol 57 1093 1099
87. H Abou-Gazar E Bedir S Takamatsu D Ferreira IA Khan 2004 Antioxidant lignans from Larrea tridentata Phytochemistry 65 2499 2505
88. JL Thistle PA Cleary JM Lachin MP Tyor T Hersh 1984 The natural history of cholelithiasis: the national cooperative gallstone study Ann Intern Med 101 171 175
89. N Lawrentschuk PM Hewitt MG Pritchard 2003 Elective laparoscopic cholecystectomy: implications of prolonged waiting times for surgery ANZ J Surg 73 890 893
90. Olson DW, de Gara CJ (2002) How long do patients wait for elective general surgery? Can J Surg 45:31-33
91. D Rutledge D Jones R Rege 2000 Consequences of delay in surgical treatment of biliary disease Am J Surg 180 466 469
92. B Salman O Yuksel O Irkorucu N Akyurek T Tezcaner I Dogan O Erdem E Tatlicioglu 2005 Urgent laparoscopic cholecystectomy is the best management for biliary colic: a prospective randomized study of 75 cases Dig Surg 22 95 99
93. T Sauerbruch M Delius G Paumgartner J Holl O Wess W Weber W Hepp W Brendel 1986 Fragmentation of gallstones by extracorporeal shock waves N Engl J Med 314 818 822
94. N Villanova F Bazzoli F Taroni R Frabboni G Mazzella D Festi L Barbara E Roda 1989 Gallstone recurrence after successful oral bile acid treatment: a 12 year follow-up study and evaluation of long term postdissolution treatment Gastroenterology 97 726 731
95. M Sackmann H Niller U Klueppelberg C von Ritter J Pauletzki J Holl F Berr M Neubrand T Sauerbruch G Paumgartner 1994 Gallstone recurrence after shock-wave therapy Gastroenterology 106 225 230
96. F Berr M Mayer MF Sackmann T Sauerbruch J Holl G Paumgartner 1994 Pathogenic factors in early recurrence of cholesterol gallstones Gastroenterology 106 215 224
97. GS Tint G Salen A Colalillo D Graber D Verga J Speck S Shefer 1982 Ursodeoxycholic acid: a safe and effective agent for dissolving cholesterol gallstones Ann Intern Med 97 351 356
98. WH Bachrach AF Hofmann 1982 Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part I Dig Dis Sci 27 737 761
99. TJ Meredith GV Williams PN Maton GM Murphy HM Saxton RH Dowling 1982 Retrospective comparison of 'Cheno' and 'Urso' in the medical treatment of gallstones Gut 23 382 389
100. S Tomida M Abei T Yamaguchi Y Matsuzaki J Shoda N Tanaka T Osuga 1999 Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: a cohort analysis Hepatology 30 6 13
101. NG Venneman MG Besselink YC Keulemans GP Vanberge-Henegouwen MA Boermeester IA Broeders PM Go KJ van Erpecum 2006 Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy Hepatology 43 1276 1283
102. JL Thistle NF Larusso AF Hofmann J Turcotte GL Carlson BJ Ott 1982 Differing effects of ursodeoxycholic or chenodeoxycholic acid on biliary cholesterol saturation and bile acid metabolism in man. A dose-response study Dig Dis Sci 27 161 168
103. JL Thistle AF Hofmann PY Yu B Ott 1977 Effect of varying doses of chenodeoxycholic acid on bile lipid and biliary bile acid composition in gallstone patients: a dose-response study Am J Dig Dis 22 1 6
104. LJ Schoenfield JW Marks 1993 Oral and contact dissolution of gallstones Am J Surg 165 427 430
105. RG Danzinger AF Hofmann LJ Schoenfield JL Thistle 1972 Dissolution of cholesterol gallstones by chenodeoxycholic acid N Engl J Med 286 1 8
106. HB Anderson 1914 The medical treatment of cholelithiasis Can Med Assoc J 4 1 8
107. S Lee 2004 Gallstones: how do we translate an old story into future therapy? Nat Clin Pract Gastroenterol Hepatol 1 2 3
108. Q Chen J Amaral P Biancani J Behar 1999 Excess membrane cholesterol alters human gallbladder muscle contractility and membrane fluidity Gastroenterology 116 678 685
109. Strasberg S (1995), Acute calculus cholecystitis. In: Berk JE (ed) Gastroenterology, 5th edn. Saunders, Philadelphia, pp 2635-2664
110. NA Womack EM Bricker 1944 Pathogenesis of cholecystitis Arch Surg 44 658
111. ZL Xiao AK Rho P Biancani J Behar 2002 Effects of bile acids on the muscle functions of guinea pig gallbladder Am J Physiol Gastrointest Liver Physiol 283 G87 G94
112. ZL Xiao J Amaral P Biancani J Behar 2005 Impaired cytoprotective function of muscle in human gallbladders with cholesterol stones Am J Physiol Gastrointest Liver Physiol 288 G525 G532
113. JR Lane EM Starbuck AK Johnson DA Fitts 1999 Effects of bile duct ligation and captopril on salt appetite and renin-aldosterone axis in rats Physiol Behav 66 419 425
114. NZ Canturk Z Canturk G Ozbilim C Yenisey 2000 Protective effect of vitamin E on gastric mucosal injury in rats with biliary obstruction Can J Gastroenterol 14 499 503
115. P Montilla A Cruz FJ Padillo I Tunez F Gascon MC Munoz M Gomez C Pera 2001 Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats J Pineal Res 31 138 144
116. A Polat MH Emre 2006 Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats J Gastroenterol 41 433 439
117. Y Ohta M Kongo T Kishikawa 2003 Therapeutic effect of melatonin on cholestatic liver injury in rats with bile duct ligation Adv Exp Med Biol 527 559 565
118. Y Ohta Y Imai T Matsura K Yamada K Tokunaga 2005 Successively postadministered melatonin in prevents disruption of hepatic antioxidant status with bile duct ligation J Pineal Res 39 367 374
119. Y Ohta M Kongo-Nishimura Y Imai T Matsura A Kitagawa K Yamada 2006 Alpha-tocopherol protects against alpha-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin Chem Biol Interact 161 115 124
120. L Vitetta A Sali P Little L Mrazek 2000 Gallstones and gall bladder carcinoma Aust NZ J Surg 70 667 673
121. F Nervi I Duarte G Gomez G Rodriguez G Del Pino O Ferrerio C Covarrubias V Valdivieso MI Torres A Urzua 1988 Frequency of gallbladder cancer in Chile, a high-risk area Int J Cancer 41 657 660
122. I Serra AK Diehl 2002 Number and size of stones in patients with asymptomatic and symptomatic gallstones and gallbladder carcinoma J Gastrointest Surg 6 272 273
123. AB Lowenfels P Maisonneuve P Boyle WA Zatonski 1999 Epidemiology of gallbladder cancer Hepatogastroenterology 46 1529 1532
124. CM Lam AW Yuen AC Wai RM Leung AY Lee KK Ng ST Fan 2005 Gallbladder cancer presenting with acute cholecystitis: a population-based study Surg Endosc 19 697 701
125. A Abou-Saif FH Al-Kawas 2002 Complications of gallstone disease: Mirizzi syndrome, cholecystocholedochal fistula, and gallstone ileus Am J Gastroenterol 97 249 254
126. Tucker L, Tangedahl TN (1979) Manifestations of gallstone disease. Postgrad Med 66:179-180, 183-184
127. JE Losanoff BW Richman JW Jones 2002 Complications of gallstone disease: gallstone ileus Am J Gastroenterol 97 1843 1844
128. Centers for Disease Control and Prevention (2003) Trends in Aging-United States and worldwide. MMWR Morb Mortal Wkly Rep 52:101-104,106
129. DQ Wang 2002 Aging per se is an independent risk factor for cholesterol gallstone formation in gallstone susceptible mice J Lipid Res 43 1950 1959
130. M Karasek 2004 Melatonin, human aging, and age-related diseases Exp Gerontol 39 1723 1729
131. M Karasek K Winczyk 2006 Melatonin in humans J Physiol Pharmacol 57 19 39
132. AK Diehl WH Schwesinger DR Holleman Jr JB Chapman WE Kurtin 1994 Gallstone characteristics in Mexican Americans and non-Hispanic whites Dig Dis Sci 39 2223 2228
133. S Puppala GD Dodd S Fowler R Arya J Schneider VS Farook R Granato TD Dyer L Almasy CP Jenkinson AK Diehl MP Stern J Blangero R Duggirala 2006 A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans Am J Hum Genet 78 377 392
134. S Mann 2003 Melatonin for ulcerative colitis? Am J Gastroenterol 98 232 233
135. MD Maldonado F Murillo-Cabezas MP Terron LJ Flores DX Tan LC Manchester RJ Reiter 2007 The potencial of melatonin in reducing morbidity-mortality alter craniocerebral trauma J Pineal Res 42 1 11
136. DX Tan LC Manchester MP Terron LJ Flores RJ Reiter 2007 One molecule, many derivatives: a never-ending interaction of melatonin with oxygen and reactive nitrogen species? J Pineal Res 42 28 42
137. K Manda M Ueno K Anzai 2007 AFMK, a melatonin metabolite, attenuates X-ray-induces oxidative damageg to DNA, proteins and lipids in mice J Pineal Res 42 386 394
138. S Cuzzocrea RJ Reiter 2002 Pharmacological actions of melatonin in acute and chronic inflammation Curr Top Med Chem 2 153 166
139. MI Rodriguez G Escamez LC Lopez A Lopez JA Garcia F Ortiz D Acuna-Castroviejo 2007 Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice J Pineal Res 42 272 279
140. V Nosalova M Zeman S Cerna J Novarova M Zakalova 2007 Protective effect of melatonin in acetic acid induces colitis in rats J Pineal Res 42 364 370
141. E Gitto M Karbownik RJ Reiter DX Tan S Cuzzocrea P Chiurazzi S Cordaro G Corona G Trimarchi I Barberi 2001 Effects of melatonin treatment in septic newborns Pediatr Res 50 756 760
142. E Gitto RJ Reiter G Sabatino G Buonocore C Romero P Gitto C Bugge G Trimarchi J Barberi 2005 Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment J Pineal Res 39 387 393
143. E Gitto RJ Reiter SP Cordaro M La Rosa P Chiurazzi G Trimanchi P Gitto MP Calabro I Barberi 2004 Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin Am J Perinatol 21 209 216
144. G Klupinska T Poplawski J Drzewoski A Harasiuk RJ Reiter J Blasiak J Chojnacki 2007 Therapeutic effect of melatonin in patients with functional dyspepsia J Clin Gastroenterol 41 270 274
145. A Cutando G Gomez-Moreno C Arana G Escames D Acuna-Castroviejo 2007 Melatonin reduces oxidative stress because of tooth removal J Pineal Res 42 419 420