Pharmacological inhibition of poly(ADP-ribose) polymerase activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells

International Journal of Oncology

Volumn 34, Issue 3, 2009, Pages 861-872

  Lacal, Pedro M ^a   Tentori, Lucio ^b   Muzi, Alessia ^b   Ruffini, Federica ^a   Dorio, Annalisa Susanna ^b   Xu, Weizheng ^c   Arcelli, Diego ^a   Zhang, Jie ^c   Graziani, Grazia ^b  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c EISAI INC   (United States)

Author keywords

Angiogenesis; Endothelial cell; Poly(ADP ribose) polymerase

Indexed keywords

10 (4 METHYLPIPERAZIN 1 YLMETHYL) 2H 7 OXA 1,2 DIAZABENZO[DE]ANTHRACEN 3 ONE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; GPI 15427; INHIBITOR OF DIFFERENTIATION 1; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OCTAMER TRANSCRIPTION FACTOR 1; SYNDECAN 4; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CELL LINE, TUMOR; DOWN-REGULATION; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; POLY(ADP-RIBOSE) POLYMERASES; SYNDECAN-4;

EID: 64549160302     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000213     Document Type: Article

References (45)

1. Hassa PO and Hottiger MO: The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci 13: 3046-3082, 2008.
2. Yélamos J, Schreiber V and Dantzer F: Toward specific functions of poly(ADP-ribose) polymerase-2. Trends Mol Med 14: 169-178, 2008.
3. Schreiber V, Amé JC, Dollé P, et al: Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem 277: 23028-23036, 2002.
4. Tentori L and Graziani G: Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacol Res 52: 25-33, 2005.
5. Galande S and Kohwi-Shigematsu T: Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences. J Biol Chem 274: 20521-20528, 1999.
6. Malanga M and Althaus FR: Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and induces DNA strand break resealing. J Biol Chem 279: 5244-5248, 2004.
7. Ghodgaonkar MM, Zacal N, Kassam S, Rainbow AJ and Shah GM: Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts. DNA Repair 7: 617-632, 2008.
8. Farmer H, McCabe N, Lord CJ, et al: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434: 917-921, 2005.
9. Bryant HE, Schultz N, Thomas HD, et al: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434: 913-917, 2005.
10. Tentori L, Lacal PM, Muzi A, et al: Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis. Eur J Cancer 43: 2124-2133, 2007.
11. Rajesh M, Mukhopadhyay P, Godlewski G, Bátkai S, Haskó G, Liaudet L and Pacher P: Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. Biochem Biophys Res Commun 350: 1056-1062, 2006.
12. Rajesh M, Mukhopadhyay P, Bátkai S, Godlewski G, Haskó G, Liaudet L and Pacher P: Pharmacological inhibition of poly (ADP-ribose) polymerase inhibits angiogenesis. Biochem Biophys Res Commun 350: 352-357, 2006.
13. Pyriochou A, Olah G, Deitch EA, Szabó C and Papapetropoulos A: Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34. Int J Mol Med 22: 113-118, 2008.
14. Tentori L, Muzi A, Dorio AS, et al: Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity. Eur J Cancer 44: 1302-1314, 2008.
15. Tentori L, Vergati M, Muzi A, et al: Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs. Int J Oncol 27: 525-535, 2005.
16. Tentori L, Leonetti C, Scarsella M, et al: Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin Cancer Res 9: 5370-5379, 2003.
17. Bakondi E, Bai P, Szabo EE, Hunyadi J, Gergely P, Szabo C and Virag L: Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using bio-tinylated NAD substrate. J Histochem Cytochem 50: 91-98, 2002.
18. Tibshirani R, Hastie T, Narasimhan B and Chu G: Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci USA 99: 6567-6572, 2002.
19. Gentleman R and Carey VJ: Visualization and annotation of genomic experiments. In: The Analysis of Gene Expression Data. Parmigiani G, Garrett ES, Irizarry RA and Zeger SL (eds). Springer, New York, pp46-72, 2003.
20. Al-Shahrour F, Minguez P, Tárraga J, et al: BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments. Nucleic Acids Res 34: W472-W476, 2006.
21. Bernfield M, Götte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J and Zako M: Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 68: 729-777, 1999.
22. Tkachenko E, Elfenbein A, Tirziu D and Simons M: Syndecan-4 clustering induces cell migration in a PDZ-dependent manner. Circ Res 98: 1398-1404, 2006.
23. Nunes SS, Outeiro-Bernstein MA, Juliano L, et al: Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1. J Cell Physiol 214: 828-837, 2008.
24. Benezra R, Rafii S and Lyden D: The Id proteins and angiogenesis. Oncogene 20: 8334-8341, 2001.
25. Nishiyama K, Takaji K, Kataoka K, et al: Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis. Circulation 112: 2840-2850, 2005.
26. Sakurai D, Tsuchiya N, Yamaguchi A, et al: Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. J Immunol 173: 5801-5809, 2004.
27. Wiley SR, Cassiano L, Lofton T, et al: A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15: 837-846, 2001.
28. Horsley V and Pavlath GK: NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol 156: 771-774, 2002.
29. Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P and Shuai K: Specific inhibition of Stat3 signal transduction by PIAS3. Science 278: 1803-1805, 1997.
30. Bartoli M, Platt D, Lemtalsi T, Gu X, Brooks SE, Marrero MB and Caldwell RB: VEGF differentially activates STAT3 in microvascular endothelial cells. FASEB J 17: 1562-1564, 2003.
31. Aguilar-Quesada R, Muñoz-Gámez JA, Martín-Oliva D, et al: Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation. Curr Med Chem 14: 1179-1187, 2007.
32. Kraus WL and Lis JT: PARP goes transcription. Cell 113: 677-683, 2003.
33. Malanga M, Pleschke JM, Kleczkowska HE and Althaus FR: Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J Biol Chem 273: 11839-11843, 1998.
34. Malanga M and Althaus FR: The role of poly(ADP-ribose) in the DNA damage signaling network. Biochem Cell Biol 83: 354-364, 2005.
35. Jagtap P and Szabo C: Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 4: 421-440, 2005.
36. Andreone TL, O'Connor M, Denenberg A, Hake PW and Zingarelli B: Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts. J Immunol 170: 2113-2120, 2003.
37. Martin-Oliva D, Aguilar-Quesada R, O'valle F, et al: Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. Cancer Res 66: 5744-5756, 2006.
38. Pleschke JM, Kleczkowska HE, Strohm M and Althaus FR: Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem 275: 40974-40980, 2000.
39. Nie J, Sakamoto S, Song D, Qu Z, Ota K and Taniguchi T: Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase. FEBS Lett 424: 27-32, 1998.
40. Ha HC: Defective transcription factor activation for pro-inflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia. Proc Natl Acad Sci USA 101: 5087-5092, 2004.
41. Villano CM and White LA: Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Toxicol Appl Pharmacol 214: 219-229, 2006.
42. Ling M-T, Kwok W-K, Fung MK, Xianghong W and Wong Y-C: Proteasome mediated degradation of Id-1 is associated with TNFα-induced apoptosis in prostate cancer cells. Carcinogenesis 27: 205-215, 2006.
43. Nemetski SM and Gardner LB: Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma. J Biol Chem 282: 240-248, 2007.
44. Ogino H, Nozaki T, Gunji A, et al: Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells. BMC Genomics 8: 41, 2007.
45. Carrillo A, Monreal Y, Ramírez P, Marin L, Parrilla P, Oliver FJ and Yélamos J: Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells. Nucleic Acids Res 32: 757-766, 2004.