Combined intratumoral regulatory T-cell depletion and transforming growth factor-Β neutralization induces regression of established AE17 murine mesothelioma tumors

Journal of Interferon and Cytokine Research

Volumn 29, Issue 4, 2009, Pages 209-215

  Kissick, Haydn T ^a   Ireland, Demelza J ^a   Beilharz, Manfred W ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MESOTHELIOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; TUMOR REGRESSION;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; MESOTHELIOMA; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

MURINAE;

EID: 64549117428     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2008.0055     Document Type: Article

References (19)

1. Barnett B, Kryczek I, Cheng P, Zou W, Curiel TJ. 2005. Regulatory T cells in ovarian cancer: biology and therapeutic potential. Am J Reprod Immunol 54(6):369-377.
2. Beven. 2004. Helping the CD8+ T-cell response. Nat Rev Immunol 4(9):595-602.
3. Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. 2005. Regulatory T cells suppress tumour-specifi c CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci USA 102(2):419-424.
4. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, Zhu Y, Wei S. 2004. Specifi c recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10(9):942-949.
5. Hegmans JP, Hemmes A, Hammad H, Boon L, Hoogsteden HC, Lambrecht BN. 2006. Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses. Eur Respir J 27(6):1086-1095.
6. Mahnke K, Schonfeld K, Fondel S, Ring S, Karakhanova S, Wiedemeyer K, Bedke T, Johnson TS, Storn V, Schallenberg S, Enk AH. 2007. Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro. Int J Cancer 120(12):2723-2733.
7. Needham DJ, Lee JX, Beilharz MW. 2006. Intra-tumoural regulatory T cells: a potential new target in cancer immunotherapy. Biochem Biophys Res Commun 343(3):684-691.
8. Rabinovich GA, Gabrilovich D, Sotomayor EM. 2007. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol. 25:267-296.
9. Ruddle JB, Prince HM. 2007. Denileukin diftitox and vision loss. Leuk Lymphoma 48(4):655-656.
10. Sakaguchi S. 2004. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531-562.
11. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda, M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155(3):1151-1164.
12. Saunier EF, Akhurst RJ. 2006. TGF beta inhibition for cancer therapy. Curr Cancer Drug Targets 6(7):565-578.
13. Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S. 2008. Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res 177:137-150.
14. Smyth MJ, Teng MW, Swann J, Kyparissoudis K, Godfrey DI, Hayakawa Y. 2006. CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer. J Immunol 176(3):1582-1587.
15. Tadokoro CE, Shakhar G, Shen S, Ding Y, Lino AC, Maraver A, Lafaille JJ, Dustin ML. 2006. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med 203(3):505-511.
16. Takeuchi M, Keino H, Kezuka T, Usui M, Taguchi O. 2004. Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice. Invest Ophthalmol Vis Sci 45(6):1879-1886.
17. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. 2006. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 7(1):83-92.
18. Yu P, Lee Y, Liu W, Krausz T, Chong A, Schreiber H, Fu YX. 2005. Intra-tumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 201(5):779-791.
19. Zou W. 2006. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6(4):295-307.