-
1
-
-
0033864011
-
Molecular genetics of Alzheimer's disease: The role of beta-amyloid and the presenilins
-
Tandon A, Rogaeva E, Mullan M, St George-Hyslop PH. (2000) Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins. Curr. Opin. Neurol. 13:377-84.
-
(2000)
Curr. Opin. Neurol
, vol.13
, pp. 377-384
-
-
Tandon, A.1
Rogaeva, E.2
Mullan, M.3
St George-Hyslop, P.H.4
-
2
-
-
0242412140
-
Plasma Aβ40 and Aβ42 and Alzheimer's disease: Relation to age, mortality, and risk
-
Mayeux R, et al. (2003) Plasma Aβ40 and Aβ42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology. 61:1185-9.
-
(2003)
Neurology
, vol.61
, pp. 1185-1189
-
-
Mayeux, R.1
-
3
-
-
34247266089
-
Release of beta-amyloid from high-density platelets: Implications for Alzheimer's disease pathology
-
Casoli T, et al. (2007) Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology. Ann. N. Y. Acad. Sci. 1096:170-8.
-
(2007)
Ann. N. Y. Acad. Sci
, vol.1096
, pp. 170-178
-
-
Casoli, T.1
-
5
-
-
36048982129
-
Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: Prediction by plasma amyloid beta 42, medial temporal lobe atrophy and ho-mocysteine
-
Blasko I, et al. (2008) Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and ho-mocysteine. Neurobiol. Aging. 29:1-11.
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 1-11
-
-
Blasko, I.1
-
6
-
-
35748972941
-
The influence of diagnosis, intra- and inter-person variability on serum and plasma Aβ levels
-
Abdullah L, et al. (2007) The influence of diagnosis, intra- and inter-person variability on serum and plasma Aβ levels. Neurosci. Lett. 428:53-8.
-
(2007)
Neurosci. Lett
, vol.428
, pp. 53-58
-
-
Abdullah, L.1
-
7
-
-
84868920786
-
-
Luis CA, et al. (2008) Serum β-amyloid levels correlate with cognitive impairment. Neuropsychol Dev. Cogn. B. Aging Neuropsychol. Cogn. 15:1-16.
-
Luis CA, et al. (2008) Serum β-amyloid levels correlate with cognitive impairment. Neuropsychol Dev. Cogn. B. Aging Neuropsychol. Cogn. 15:1-16.
-
-
-
-
8
-
-
0034703979
-
Linkage of plasma Aβp42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
Ertekin-Taner N, et al. (2000) Linkage of plasma Aβp42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 290:2303-4.
-
(2000)
Science
, vol.290
, pp. 2303-2304
-
-
Ertekin-Taner, N.1
-
9
-
-
39749090577
-
-
Plasma amyloid β protein is elevated in late-onset Alzheimer disease families
-
Ertekin-Taner N, et al. (2008) Plasma amyloid β protein is elevated in late-onset Alzheimer disease families. Neurology 70:596-606.
-
(2008)
Neurology
, vol.70
, pp. 596-606
-
-
Ertekin-Taner, N.1
-
10
-
-
0032587237
-
Evidence that Aβ42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phe-notype
-
De Jonghe C, et al. (1999) Evidence that Aβ42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phe-notype. Neurobiol. Dis. 6:280-7.
-
(1999)
Neurobiol. Dis
, vol.6
, pp. 280-287
-
-
De Jonghe, C.1
-
11
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, et al. (1996). Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:864-70.
-
(1996)
Nat. Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
-
12
-
-
3142621163
-
Familial clustering and genetic risk for dementia in a genetically isolated Dutch population
-
Sleegers K, et al. (2004). Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. Brain. 127(Pt 7):1641-9.
-
(2004)
Brain
, vol.127
, Issue.PART 7
, pp. 1641-1649
-
-
Sleegers, K.1
-
13
-
-
0028340614
-
-
Houlden H, et al. (1994). Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipopro-tein E locus. Neurosci. Lett. 174:222-4.
-
Houlden H, et al. (1994). Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipopro-tein E locus. Neurosci. Lett. 174:222-4.
-
-
-
-
14
-
-
0030614816
-
Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons
-
Evans DA, et al. (1997). Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA. 277:822-4.
-
(1997)
JAMA
, vol.277
, pp. 822-824
-
-
Evans, D.A.1
-
16
-
-
0030003819
-
15-year longitudinal study of blood pressure and dementia
-
Skoog I, et al. (1996). 15-year longitudinal study of blood pressure and dementia. Lancet. 347:1141-5.
-
(1996)
Lancet
, vol.347
, pp. 1141-1145
-
-
Skoog, I.1
-
17
-
-
0034594441
-
Midlife blood pressure and dementia: The Honolulu-Asia aging study
-
Launer LJ, et al. (2000). Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol. Aging 21:49-55.
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 49-55
-
-
Launer, L.J.1
-
18
-
-
0035897938
-
Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study
-
Kivipelto M, et al. (2001). Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ 322:1447-51.
-
(2001)
BMJ
, vol.322
, pp. 1447-1451
-
-
Kivipelto, M.1
-
19
-
-
0031976318
-
Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
-
Notkola IL, et al. (1998). Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology 17:14-20.
-
(1998)
Neuroepidemiology
, vol.17
, pp. 14-20
-
-
Notkola, I.L.1
-
20
-
-
57749116386
-
β-amyloid deposition in brain is enhanced in mouse models of arterial hypertension
-
Gentile MT, et al. (2009) β-amyloid deposition in brain is enhanced in mouse models of arterial hypertension. Neurobiol. Aging 30:222-8.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 222-228
-
-
Gentile, M.T.1
-
21
-
-
7644225312
-
RAGE (yin) versus LRP (yang) balance regulates Alzheimer amyloid β-peptide clearance through transport across the blood-brain barrier
-
Deane R, Wu Z, Zlokovic BV. (2004) RAGE (yin) versus LRP (yang) balance regulates Alzheimer amyloid β-peptide clearance through transport across the blood-brain barrier. Stroke 35(11 Suppl 1):2628-31.
-
(2004)
Stroke
, vol.35
, Issue.11 SUPPL. 1
, pp. 2628-2631
-
-
Deane, R.1
Wu, Z.2
Zlokovic, B.V.3
-
22
-
-
0025869153
-
Analysis of apolipoprotein E genotypes by the Amplification Refractory Mutation System
-
Wenham PR, Newton CR, Price WH. (1991) Analysis of apolipoprotein E genotypes by the Amplification Refractory Mutation System. Clin. Chem. 37:241-4.
-
(1991)
Clin. Chem
, vol.37
, pp. 241-244
-
-
Wenham, P.R.1
Newton, C.R.2
Price, W.H.3
-
23
-
-
34548635537
-
Cognitive domain decline in healthy apolipoprotein E epsilon4 homozy-gotes before the diagnosis of mild cognitive impairment
-
Caselli RJ, et al. (2007) Cognitive domain decline in healthy apolipoprotein E epsilon4 homozy-gotes before the diagnosis of mild cognitive impairment. Arch. Neurol. 64:1306-11.
-
(2007)
Arch. Neurol
, vol.64
, pp. 1306-1311
-
-
Caselli, R.J.1
-
24
-
-
43249124446
-
APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease
-
Cosentino S, et al. (2008) APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology. 70(19 Pt 2):1842-9.
-
(2008)
Neurology
, vol.70
, Issue.19 PART 2
, pp. 1842-1849
-
-
Cosentino, S.1
-
25
-
-
33745741303
-
Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease
-
Rockwood K. (2006) Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease. Acta. Neurol. Scand. Suppl. 185:71-7.
-
(2006)
Acta. Neurol. Scand. Suppl
, vol.185
, pp. 71-77
-
-
Rockwood, K.1
-
26
-
-
65249130278
-
Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
-
Oct 17 [Epub ahead of print
-
Haag MD, Hofman A, Koudstaal PJ, Stricker BH, Breteler MM. (2008) Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J. Neurol. Neurosurg. Psychiatry. 2008, Oct 17 [Epub ahead of print].
-
(2008)
J. Neurol. Neurosurg. Psychiatry. 2008
-
-
Haag, M.D.1
Hofman, A.2
Koudstaal, P.J.3
Stricker, B.H.4
Breteler, M.M.5
-
27
-
-
48749096049
-
Reduced risk of incident AD with elective statin use in a clinical trial cohort
-
Sparks DL, et al. (2008) Reduced risk of incident AD with elective statin use in a clinical trial cohort. Curr. Alzheimer Res. 5:416-21.
-
(2008)
Curr. Alzheimer Res
, vol.5
, pp. 416-421
-
-
Sparks, D.L.1
-
28
-
-
34548299453
-
Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
-
Wolozin B, et al. (2007) Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 5:20.
-
(2007)
BMC Med
, vol.5
, pp. 20
-
-
Wolozin, B.1
-
29
-
-
34249825804
-
Effect of HMG-CoA reductase inhibitors on beta-amyloid pep-tide levels: Implications for Alzheimer's disease
-
Hoglund K, Blennow K. (2007) Effect of HMG-CoA reductase inhibitors on beta-amyloid pep-tide levels: implications for Alzheimer's disease. CNS Drugs 21:449-62.
-
(2007)
CNS Drugs
, vol.21
, pp. 449-462
-
-
Hoglund, K.1
Blennow, K.2
-
30
-
-
47649124352
-
Effects of medications on plasma amyloid β (Aβ) 42: Longitudinal data from the VITA cohort
-
Blasko I, et al. (2008) Effects of medications on plasma amyloid β (Aβ) 42: longitudinal data from the VITA cohort. J. Psychiatr. Res. 42:946-55.
-
(2008)
J. Psychiatr. Res
, vol.42
, pp. 946-955
-
-
Blasko, I.1
-
31
-
-
0033976870
-
Transthyretin in high density lipoproteins: Association with apolipoprotein A-I
-
Sousa M, Berglund ML, Saraiva MJ. (2000) Transthyretin in high density lipoproteins: association with apolipoprotein A-I. J. Lipid Res. 41:58-65.
-
(2000)
J. Lipid Res
, vol.41
, pp. 58-65
-
-
Sousa, M.1
Berglund, M.L.2
Saraiva, M.J.3
-
32
-
-
0028921915
-
Characterization of apolipoprotein J-Alzheimer's Aβ interaction
-
Matsubara E, Frangione B, Ghiso J. (1995) Characterization of apolipoprotein J-Alzheimer's Aβ interaction. J. Biol. Chem. 270:7563-7.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 7563-7567
-
-
Matsubara, E.1
Frangione, B.2
Ghiso, J.3
-
33
-
-
0028609448
-
The soluble form of Alzheimer's amyloid β protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma
-
Koudinov A, Matsubara E, Frangione B, and Ghiso J. (1994) The soluble form of Alzheimer's amyloid β protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma. Biochem. Biophys. Res. Commun. 205:1164-71.
-
(1994)
Biochem. Biophys. Res. Commun
, vol.205
, pp. 1164-1171
-
-
Koudinov, A.1
Matsubara, E.2
Frangione, B.3
Ghiso, J.4
-
34
-
-
33645502137
-
High density lipoproeins bind Aβ and apolipoprotein C-II amyloid fibrils
-
Wilson LM, et al. (2006). High density lipoproeins bind Aβ and apolipoprotein C-II amyloid fibrils. J. Lipid Res. 47:755-60.
-
(2006)
J. Lipid Res
, vol.47
, pp. 755-760
-
-
Wilson, L.M.1
-
35
-
-
33644592540
-
Plasma Aβ42 correlates positively with increased body fat in healthy individuals
-
Balakrishnan K, et al. (2005). Plasma Aβ42 correlates positively with increased body fat in healthy individuals. J. Alzheimers Dis. 8:269-82.
-
(2005)
J. Alzheimers Dis
, vol.8
, pp. 269-282
-
-
Balakrishnan, K.1
-
36
-
-
0036630803
-
Serum creatinine levels correlate with plasma amyloid amyloid β protein
-
Arvanitakis Z, Lucas JA, Younkin LH, Younkin SG, Graff-Radford NR. (2002) Serum creatinine levels correlate with plasma amyloid amyloid β protein Alzheimer Dis. Assoc. Disord. 16:187-90.
-
(2002)
Alzheimer Dis. Assoc. Disord
, vol.16
, pp. 187-190
-
-
Arvanitakis, Z.1
Lucas, J.A.2
Younkin, L.H.3
Younkin, S.G.4
Graff-Radford, N.R.5
-
37
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen S, et al. (2001). A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414:212-6.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
-
38
-
-
46049108790
-
No advantage of Aβ 42- lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
-
Szekely CA, et al. (2008) No advantage of Aβ 42- lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology 70:2291-8.
-
(2008)
Neurology
, vol.70
, pp. 2291-2298
-
-
Szekely, C.A.1
-
39
-
-
65249098696
-
Safety and efficacy of tarenflurbil in subjects with mild Alzheimer's disease: Results from an 18-month multi-center phase 3 trial
-
Green RC, Schneider LS, Hendrix SB, Zavitz KH, Swabb E. (2008) Safety and efficacy of tarenflurbil in subjects with mild Alzheimer's disease: results from an 18-month multi-center phase 3 trial. Alzheimers Dement. 4(4 Suppl):T165.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.4 SUPPL.
-
-
Green, R.C.1
Schneider, L.S.2
Hendrix, S.B.3
Zavitz, K.H.4
Swabb, E.5
-
40
-
-
61849132050
-
Onset of Alzheimer's dementia occurs commonly without prior cognitive impairment: Results from the Alzheimer's disease anti-inflammatory prevention trial (ADAPT)
-
Breitner JCS (2008). Onset of Alzheimer's dementia occurs commonly without prior cognitive impairment: results from the Alzheimer's disease anti-inflammatory prevention trial (ADAPT). Alzheimers Dement. 4(4 Suppl):T130-1.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.4 SUPPL.
-
-
Breitner, J.C.S.1
|