Physical activity in leisure time: Impact on mortality. Risk and benefits

Danish Medical Bulletin

Volumn 56, Issue 1, 2009, Pages 40-71

  Schnohr, Peter ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ATHLETE; CARDIOVASCULAR RISK; CIGARETTE SMOKING; DEATH; DOPING; EXERCISE; EXERCISE INTENSITY; FITNESS; HEART ARREST; HUMAN; ISCHEMIC HEART DISEASE; JOGGING; LEISURE; LIFE SATISFACTION; LIFE STRESS; LONGEVITY; MORTALITY; PHYSICAL ACTIVITY; REVIEW; RISK ASSESSMENT; RISK REDUCTION; SOCIAL STATUS; SUDDEN DEATH; WELLBEING; ADULT; AGED; DENMARK; FEMALE; MALE; MIDDLE AGED; MOTOR ACTIVITY; SPORT; STATISTICS;

ADULT; AGED; AGED, 80 AND OVER; DENMARK; FEMALE; HUMANS; LEISURE ACTIVITIES; MALE; MIDDLE AGED; MORTALITY; MOTOR ACTIVITY; RISK ASSESSMENT; SPORTS; YOUNG ADULT;

EID: 64549107646     PISSN: 16039629     EISSN: 16039629     Source Type: Journal    
DOI: None     Document Type: Review

References (190)

1. Aadahl M, Jørgensen T. Validation of a new self-report instrument for measuring physical activity. Med Sci Sports Exerc. 2003;35:1196-1202.
2. Aadahl M, Kjær M, Kristensen JH, Mollerup B. Jørgensen T. Self-reported physical activity compared with maximal oxygen uptake in adults. Eur J Cardiovasc Prev Rehabil 2007;14:422-428.
3. Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H. Walking and dementia in physically capable elderly men. JAMA 2004;292:1447-1453.
4. Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R, Hollenbeck A, Leitzmann MF. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006;355:763-778.
5. Albert CM, Mittleman MA, Chae CU, Lee I-M, Hennekens CH, Manson JE. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med 2000;343:1355-1361.
6. Andersen LB, Schnohr P, Schroll M, Hein HO. All-cause mortality associated with physical activity during leisure time, work, sports and cycling to work. Arch Intern Med 2000;160:1621-1628.
7. Anderson KM, Wilson PWF, Odell PM, Kannel WB. An updated coronary risk profile:A statement for health professionals. Circulation 1991;83:356-362.
8. Appleyard M, Hansen AT, Schnohr P, Jensen G, Nyboe J. The Copenhagen City Heart Study. Østerbroundersøgelsen. A book of tables with data from the first examination (1976-78) and a five year follow-up (1981-83). Scand J Soc Med 1989; 170 (suppl 41):1-160.
9. Backlund E, Sorlie PD, Johnson NJ. A comparison of the relationships of education and income with mortality:the national longitudinal mortality study. Social Science & Medicine 149;49:1373-1384.
10. Barisal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007;298:309-316.
11. Barengo NC, Hu G, Lakka TA. Pekkarinen H, Nissinen A, Tuomilehto J. Low physical activity as a predictor for total and cardiovascular disease mortality in middle-aged men and women in Finland: Eur Heart J 2004;25:2204-2211.
12. Barengo NC, Kastarinen M, Lakka T, Nissinen A, Tuomilehto J. Different forms of physical activity and cardiovascular risk factors among 24-64-year-old men and women in Finland. Eur J Cardiovasc Prev Rehabil 2006;13:51-59.
13. Bassler TJ. Marathon running and immunity to atherosclerosis. Ann N Y Sci. 1977:301:579-592.
14. Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Eng J Med 2000:342:1878-1886
15. Bijnen FCH, Caspersen CJ, Feskens EJM, Saris WHM, Mosterd WL, Kromhout D. Physical activity and 10-year mortality from cardiovascular diseases and all causes. The Zutphen Elderly Study. Arch Intern Med 1998; 158:1499-1505.
16. Bijnen FCH, Feskens EJM, Caspersen CJ, Nagelkerke N, Mosterd WL, Kromhout D. Baseline and previous physical activity in relation to mortality in elderly men. The Zutphen Elderly Study. Am J Epidemiol 1999;150:1289-1296.
17. Blair SN, Haskell WL, Ho P, Paffenbarger RS Jr, Vranizan KM, Farquhar JW, Wood PD. Assessment of habitual physical activity by a seven day recall in a community survey and controlled experiments. Am J Epidemiol 1985; 122:794-804.
18. Blair SN, Kohl HW III, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989;262:2395-2401.
19. Blair SN, Kohl HW III, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality. JAMA 1995;273: 1093-1098.
20. Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc 2001;33, Suppl S379-S399.
21. Bouchard C, Warwick DE, Treva R, Pérusse L, Gagnon J, Province MA, Leon AS, Rao DC, Skinner JS, Wilmore JH. Familial resemblance for VO2max in the sedentary state:the HERITAGE family study. Med Sci Sports Exerc 1998;30:252-258.
22. Bucksch J. Physical activity of moderate intensity in leisure time and the risk of all cause mortality. Br J Sports Med 2005;39:632-638.
23. Bøje O. Idrætsmedicin. Copenhagen 1942. Einar Munksgaard.
24. Chave SPW, Morris JN, Moss S. Sernmence AM. Vigorous exercise in leisure time and the death rate:a study of male civil servants. J Epidemiol Community Health 1978:32:239-243.
25. Clayton D, Hills M. Statistical models in epidemiology. Oxford, United Kingdom:Oxford University Press, 1993.
26. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 1999;341:1351-1357.
27. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000;342: 1887-1892.
28. Corrado D, Basso C, Rizzoli G, Schiavon M, Thieme G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003;42:1959-1963.
29. Curb JD, Abbott RD, Rodriguez BL, Masaki KH, Chen R. Popper JS, Petrovich H, Ross GW, Schatz IJ, Belleau GC, Yano K. High density lipoprotein cholesterol and the risk of stroke in elderly men. The Honolulu Heart Program. Am J Epidemiol 2004;160:150-157.
30. Dansk Sportslexicon, Lundqvist Andersen A, Budtz-Jorgensen J, Gay V, editors. Standard Forlaget, 1944, Copenhagen.
31. De Geus EJC, Kluft C, De Bart ACW, Van Doornen LJP. Effects of exercise training on plasminogen activator inhibitor activity. Med Sci Sports Exerc 1992;24:1210-1219.
32. Doll R, Hill AB. The mortality of doctors in relation to their smoking habits. BMJ 1954;1:1451-1455.
33. Dunne AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO. Exercise treatment for depression. Efficacy and dose response. Am J Prev Med 2005;28:1-8.
34. Erikssen G, Liestol K, Bjørnholt J, Thaulow E, Sandvik L, Erikssen J. Changes in physical fitness and changes in mortality. Lancet 1998;352:759-762.
35. Farahmand BY, Ahlbom A, Ekblom Ö, Ekblom B, Hallmarker U, Aronson D, Brobert GP. Mortality amongst participants in Vasaloppet:a classical long-distance ski race in Sweden. J Intern Med 2003;253:276-283.
36. Farahmand B, Hllmarker U, Brobert GP, Ahlbom A. Acute mortality during long-distance ski races (Vasaloppet). Scand J Med Sports 2007;17:356-361
37. Feng JH, MacGregor GA. Blood pressure is the most important cause of death and disability in the world. Eur heart J 2007;9 (suppl. B):B23-B28.
38. Ferucci, L, Izmirlian G, Leveille S, Ph illips CL, Corti M-C, Brock DB, Guralnik JM. Smoking, physical activity, and active life expectancy. Am J Epidemiol 1999;149:645-653.
39. Fox K, Borer JS, Camm AJ, Danchin N, Ferrari R, Sendon JLL, Steg PG, Tardif J-C, Tavazzi, L, Tendera M, Resting heart rate in cardiovasclar disease. J Am Coll Cardiol 2007;50:823-830.
40. Geffken DF, Gusman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001;153:242-250.
41. Gotto AM, LaRosa JC, Hunninghake D, Grundy SM, Wilson PW, Clarkson TB, Hay JW, Goodman DS, The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. Circulation 1990;81:1721-1733.
42. Graham I, Atar A, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, Dallongeville J, De Backer G, Ebrahim S, Gjelsvik B, Herrmann-Lingen C, Hoes A, Humphries S, Knapton M, Perk J, Priori SG, Pyörälä K, Reiner Z, Ruilope L, Sans-Menendez S, Reimer WSO, Weissberg P, Wood D, Yarnell J. Zamorano JL. European guidelines on cardiovascular disease prevention in clinical practice:executive summary Fourth Joint Task Force of European Society of Cardiology and other Societies on cardiovascular disease prevention in clinical practice. Eur J Cardiovasc Prev Rehabil 2007;14 (Supp 2):E1-E40.
43. Gregg EW, Cauley JA, Stone K. Thompson TJ, Bauer DC, Cummings SR, Ensrud KE. Relationship of changes in physical activity and mortality among older women. JAMA 2003;289:2379-2386.
44. Gulati M, Pandey DK, Arnsdorf MF, Lauderdale DS, Thisted RA, Wicklund RH, Al-Hani AJ, Black HR. Exercise capacity and the risk of death in women. The St James women take heart project. Circulation 2003;108: 1554-1559.
45. Grønbæk M. Wine and mortality. Evidence for casual inference? Thesis. Dan Med Bull 2000;47:271-282.
46. Grønbæk M, Becker U, Johansen D, Gottschau A, Schnohr P, Hein HO, Jensen G, Sørensen TIA. Type of alcohol consumed and mortality from all causes, coronary heart disease and cancer. Ann Intern Med 2000;411-419.
47. Haapanen N, Miilunpalo S, Vuori I, Oja P, Pasanen M. Characteristics of leisure time physical activity associated with decreased risk of premature all-cause and cardiovascular disease mortality in middle-aged men. Am J Epidemiol 1996;143:870-880.
48. Hagerup L. Coronary heart disease risk factors in men and women. Thesis. Acta Med Scand 1974;Suppl 557.
49. Hakim AA, Petrovitch H, Burchfiel CM, Ross GW, Rodriguez BL, White LR, Yano K, Curb JD, Abbott RD. Effects of walking on mortality among non smoking retired meg. N Engl J Med 1998;338:94-99.
50. Hambrecht R, Niebauer J, Marburger C, Grunze M, Kälberer B, Hauer K, Schlierf G, Kübler W, Schuler G. Various intensities of leisure time physical activity in patients with coronary artery disease: Effects on cardio-respiratory fitness and progression of coronary atherosclerotic lesions. J AM Coll Cardiol 1993;22:468-477.
51. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000;342:454-460.
52. Haapanen N, Miilunpalo S, Vuori I, Oja P, Pasanen M. Characteristics of leisure time physical activity associated with decreased risk of premature all-cause and cardiovascular disease mortality in middle-aged men. Am J Epidemiol 1996;143:870-880.
53. Hartung GH, Foreyt JP, Mitchell RE, Vlasek I, Gotto AM. Relation of diet to high-density-lipoprotein cholesterol in middle-aged marathon runners, joggers and inactive men. N Engl J Med 1980;302:357-361.
54. Haskell WL, Taylor HL, Wood P D, Schrott H, Heiss G. Strenous physical activity, treadmill exercise test performance and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study Circulation 1980;62 (suppl IV):IV-53-IV-61.
55. Hein HO, Suadicani P, Gyntelberg F. Physical finess or physical activity as a predictor of ischaemic heart disease? A 17-year follow-up in the Copenhagen Male Study J Intern Med 1992;232:471-479.
56. Hill AB. The environment and disease:Association or causation? Proc Royal Soc Med. 1965;58:295-300.
57. Hu G, Qiau Q, Jousilahti P, Lakka TA, Barengo NC, Tuomilehto, J. Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes. Diabetes Care 2005:28:799-805.
58. Hull SS, Vanoli E, Adamson PB, Verrier RL, Foreman RD, Schwartz PJ. Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation 1994;89:548-552.
59. Iversen A, Jensen JS, Scharling, Schnohr P. Hypercholesterolaemia and risk of coronary heart disease in the elderly:Impact of age. The Copenhagen City Heart Study. For J Intern Med 2008. In press..
60. Jensen G. Epidemiology of chest pain and angina pectoris, with special reference to treatment needs. Thesis. Acta Med Scand 1984;suppl 682.
61. Jeppesen J, Hein HO, Suadicani P, Gyntelberg F. High triglycerides and low HDL cholesterol and blood pressure and risk of ischemic heart disease. Hypertension 2000;36:226-232.
62. Jouven X, Empana J-P, Schwartz PJ, Desnos M, Courbon D, Ducimetière P. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 2005;352:1951-1958.
63. Kannel WB, Dawber TR, Kagan A. Revotskie N, Stokes J, III. Factors of risk in the development of coronary heart disease - six-year follow-up experience. The Framingham Study. Ann Intern Med 1961:55:33-50.
64. Kannel WB, Gordon T Schwartz MJ. Systolic versus diastolic blood pressure and the risk of coronary heart disease. The Framingham Study. Amer J Cardiol 1971:27:335-346.
65. Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipo-proteins, and the risk of coronary heart disease. The Framingham Study Ann Intern Med 1971;74:1-12.
66. Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipo-proteins, and risk of coronary heart disease. The Framingham Study. Ann Intern Med 1971;74:1-12.
67. Kannel WB, Sorlie PS. Some health benefits of physical activity: the Framingham Study. Arch Intern Med 1979;139:857-861.
68. Kaplan GA, Strawbridge WJ, Cohen RD, Hungerford LR. Natural history of leisure-time physical activity and its correlates: Associations with mortality from all causes and cardiovascular disease over 28 years. Am J Epidemiol 1996;144:793-797.
69. Karmisholt K, Gyntelberg F, Gøtzsche PC. Physical activity for primary prevention of disease. Dan Med Bull 2005;52:86-89.
70. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers. J Am Coll Cardiol 2005;45:1563-1569.
71. Kay SJ, Singh MAF. The influence of physical activity on abdominal fat: a systematic review of the literature. Obesity 2006;7:183-200.
72. Kesaniemi YA, Danforth E Jr, Jensen MD, Kopelman PG, Lefebvre P, Reeder BA. Dose-response issues concerning physical activity and health: an evidence-based symposium. Consensus statement. Med Sci Sports Exerc 2001;33:S351-S358.
73. Keys A. ed. Coronary Heart Disease in seven countries. Circulation 1970;41 (suppl 1):I-1-I-211.
74. Kiens B, Jørgensen I, Lewis S, Jensen G, Lithell H, Vessby B, Hoe S, Schnohr P. Increased plasma HDL-cholesterol and apo A-1 in sedentary middle-aged men after physical conditioning. Eur J Clin Invest 1980;10:203-209.
75. Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K, Ohasi Y, Yamada N, Sone H. Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol. A meta-analysis. Arch Intern Med 2007; 167:999-1008.
76. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa GP, Otvos JD, Kulkarni KR, Sclentz CA. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002;347:1483-1492.
77. Kronmal RA, Cain KC, Ye Z, Omenn GS. Total serum cholesterol levels and mortality risk as a function of age. Arch Intern Med. 1993:153:1065-1073.
78. Kujala UM, Kaprio J, Sarna S, Koskenvuo M. Relationship of leisure-time physical activity and mortality. The Finnish twin cohort. JAMA 1998;279: 440-444.
79. Kull M. The relationships between physical activity, health status and psychological well-being of fertility-aged women. Scand J Med Sci Sports 2002;12:241-247.
80. Lantz PM, House JS, Lepkowski JM, Williams DR, Mero RP, Chen J. Socio-economic factors, health behaviours, and mortality Results from a Nationally Representative Prospective Study of US Adults. JAMA 1998;279: 1703-1708.
81. LaPorte RE, Montoye HJ, Caspersen CJ. Assessment of physical activity in epidemiologic research:problems and prospects. Public Health Rep 1985: 100:131-146. U.S, Government Printing Office,Washington, D.C.
82. Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression:systematic review and meta-regression analysis of randomised controlled trials. BMJ 2001;322:763-770.
83. Lee I-M, Hsieh C-C, Paffenbarger RS Jr. Exercise intensity and longevity in men. The Harvard Alumni Health Study JAMA 1995;273:1179-1184.
84. Lee. I-M, Skerrett PJ. Physical activity and all-cause mortality:what is the dose-response relation? Med Sci Sports Exerc 2001;33:S459-S471.
85. Lee I-M. Dose-response relation between physical activity and fitness. Even a little is good:more is better. JAMA 2007;297:2137-2139.
86. Lemaitre RN, Siscovick DS, Raghunathan TE, Weinmann S, Arbogast P, Lin D-Y. Leisure-time physical activity and the risk of primary cardiac arrest. Arch Intern Med 1999;159:686-690.
87. Leon AS, Blackburn H. The relationship of physical activity to coronary heart disease and life expectancy Ann N.Y. Acad Sci 1977;301:561-578.
88. Leon AS. Cornett J, Jacobs DR, Rauramaa R. Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial. JAMA 1987;258:2388-2395.
89. Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chron Dis 1979:12:563-576.
90. Lissner L, Bengtsson C, Björkelund C, Wedel H. Physical activity levels and changes in relation to longevity. Am J Epidemiol 1996;143:54-62.
91. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. Global and regional burden of disease and risk factors, 2001:systematic analysis of population health data. Lancet 2006;367:1747-1757.
92. Lundqvist Andersen A, Budtz-Jørgensen J. Dansk Sportsleksikon. Standard Forlaget, Copenhagen 1944.
93. Lynch JW, Kaplan GA, Panuk ER, Cohen RD, Heck KE, Balfour JL, Yen IH. Income inequality and mortality in metropolitan areas of the United States. Am J Public Health 1998;88:1074-1080.
94. Medical Research Council investigation. Streptomycin treatment of pulmonary tuberculosis. BMI 1948;2:769-782
95. Medicorum Graecorum, Galeni Opera (edited by Kühn CC) p.694. Leipzig, 1821.
96. Miller NE, Førde OH, Thelle DS, Mjøs OD. The Tromsø Heart-Study. High-density lipoprotein and coronary heart-disease:A prospective case-control study. Lancet 1977, i:965-968.
97. Morris JN, Heady JA, Raffle PAB, Roberts CG, Parks JW. Coronary heart-disease and physical activity of work. Lancet 1953:ii:1053-1057 and 1111-1120.
98. Morris JN, Chawe SPW, Adam C, Sirey C, Epstein L, Sheehan DJ. Vigorous exercise in leisure-time and the incidence of coronary heart-disease. Lancet 1973;i:333-339.
99. Montoye HJ, Taylor HL. Measurement of physical activity in population studies:A review. Human Biology 1984;56:195-216.
100. Muller A. Education, income inequality, and mortality:a multiple regression analysis. BMJ 2002;324:23-25.
101. Neaton JD, Blackburn H, Jacobs D, Kuller L, Lee D-J, Sherwin R, Shih J, Stamler J, Wentworth D. Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Arch Intern Med 1992;152:1490-1500.
102. Nilsson M. Maratonlöpning. In. Nordisk Familjeboks Sportslexicon. Förlagsaktiebolaget A. Sohlman & Co, Stockholm 1943;5:312-313.
103. Noakes TD, Lionel MB, Opie LH, Rose AG, Kleynhans HT, Schepers NJ, Dowdeswell R. Autopsy-proved coronary atherosclerosis in marathon runners. N Engl J Med 1979;301:86-89.
104. Nordestgaard BG, Benn M, Schnohr P, Tybjæg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007;298;299-308.
105. Opie LH. Sudden death and sport. Lancet 1975;i:263-266.
106. Osler M, Andersen A-M N, Lund R, Holstein B. Effect of grandparent's and parent's socioeconomic position on mortality among Danish men born in 1953. Eur J Public Health 2005;15:647-651.
107. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol 1999;515:287-291
108. Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh C-C. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med 1986;314:605-613.
109. Paffenbarger RS Jr, Hyde RT, Wing AL, Lee I-M, Jung DL, Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 1993;328:538-545.
110. Paffenbarger RS Jr, Blair SN, Lee I-M. A history of physical activity, cardiovascular health and longevity:the scientific contributions of Jeremy N Morris, DSc, DPH, FRCP. Int J Epidemiol 2001;30:1184-1192.
111. Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard D, Buchner D, Ettinger W, Heath GW, King AC, Kriska A, Leon AS, Marcus BH, Morris J, Paffenbarger RS Jr, Patrick K, Pollock ML, Rippe JM, Sallis J, Wilmore JH. Physical activity and public Health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995;273:402-407.
112. Pedersen BK, Saltin B. Fysisk aktivitet - håndbog om forebyggelse og behandling. Sundhedsstyrelsen. 2003.
113. Pedersen BK, Saltin B.Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 2006;16 (suppl.1):3-63.
114. Pérusse L, Tremblay A, Leblanc C, Bouchard C. Genetic and environmental influences on level of habitual physical activity and exercise participation. Am J Epidemiol 1989;129:1012-1022.
115. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelly GA, Ray CA. American College of Sports Medicine. Position Stand. Exercise and hypertension. Med Sci Sports Exerc 2004;36:533-553.
116. Peschel T, Sixt S, Beitz F, Sonnabend M, Muth G, Thiele H, Tarnok A, Schuler G., Niebauer J. High, but not moderate frequency and duration of exercise training induces downregulation of the expression of inflammatory and atherogenic adhesion molecules. Eur J Cardiovasc Prev Rehabil 2007;14:476-482.
117. Petersen L, Schnohr P, Sørensen TIA. Longitudinal study of the long-term relation between physical activity and obesity in adults. Int J Obes 2004;28:105-112.
118. Poikolainen K. Alcohol and mortality: a review. J Clin Eoidemiol 1995;48: 455-465.
119. President's Council on Physical Fitness. Adult physical fitness:a program for men and women. US Government Printing Office: 1965. Washington, D.C.
120. Prescott E, Osler M, Hein HO, Borch-Johnsen K, Schnohr P, Vestbo J. Life expectancy in Danish women and men related to smoking habits:smoking may affect women more. J Epidemiol Community Health 1998;52:131-132.
121. Prescott E, Scharlig H, Osler M, Schnohr P. Importance of light smoking and inhalation habits on risk of myocardial infarction and all cause mortality. A 22 year follow up of 12,149 men and women in The Copenhagen City Heart Study. J Epidemiol Community Health 2002;56:702-706.
122. Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and stroke:13 000 strokes in 450 000 people in 45 prospective cohorts. Lancet 1995;346:1647-1653.
123. Prospective Studies Collaboration. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality:a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903-1913.
124. Rockhill B, Willett WC, Manson JE, Leitzmann MF, Stampfer MJ, Hunter DJ, Colditz GA. Physical activity and mortality:A prospective study among women. Am J Public Health 2001;91:578-583.
125. Rose GA, Blackburn H. Cardiovascular survey methods. Wld Health Org Monogr Ser 56 1968, Geneva.
126. Rose G, Shipley M. Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study. BMJ 1986;293: 306-307.
127. Rosengren A, Wilhelmsen L. Physical activity protects against coronary death and deaths from all causes in middle-aged men. Evidence from a 20-year follow-up of the Primary Prevention Study in Göteborg. Ann Epidemiol 1997;7:69-75.
128. Ross NA, Wolfson MC, Dunn JR, Berthelot J-M, Kaplan GA, Lynch JW. Relation between income inequality and mortality in Canada and the United States: cross sectional assessment using census data and vital statistics. BMJ 2000;320:898-902.
129. Sallis JF, Haskell WL, Wood PD, Fortmann SP, Rogers T, Blair SN, Paffenbarger RS Jr. Physical activity assessment methodology in the five-city project. Am J Epidemiol 1985;121:91-106.
130. Salonen JT, Puska P, Tuomilehto J. Physical activity and risk of myocardial infarction, cerebral stroke and death. A longitudinal study in eastern Finland. Am J Epidemiol 1982;115:526-537.
131. Saltin B, Grimby G. Physiological analysis of middle-aged and old former athletes. Comparison with still active athletes of the same ages. Circulation 1968;38:1104-1115.
132. Saltin B. Physiological effects of physical conditioning. In: Hansen AT, Schnohr P, Rose G, eds. Ischaemic heart disease. The strategy of postponement. Chicago, IL:Year Book Medical Publishers, 1977:104-115.
133. Saltin B, Pilegaard H. Metabolic fitness:Physical activity and health. Ugeskr Læger 2002;164:2156-2162.
134. Sandvik L, Erikssen J, Thaulow E, Erikssen G, Mundal R, Rodahl K. Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men. N Engl J Med 1993;328:533-537.
135. Sarna S, Sahi T, Koskenvuo M, Kaprio J. Increased life expectancy of world class male athletes. Med Sci Sports Exerc 1993;25:237-244.
136. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt M, Khaw K-T, Gudnason V. Triglycerides and the risk of coronary heart disease. 10 158 incident cases among 262 525 participants in 29 western prospective studies. Circulation 2007;115:450-458.
137. Schatz IJ, Masaki K, Yano K, Chen R, Roderiguez BL, Curb JD. Cholesterol and all-cause mortality in elderly people from the Honolulu heart program: a cohort study. Lancet 2001;358:351-355.
138. Scheinfeld A. The mortality of men and women. Scientific American 1958;198:22-27.
139. Schnohr C, Højbjerre L, Riegels M, Ledet L, Larsen T, Schultz-Larsen K, Petersen L, Prescott E, Grønbæk M. Does educational level influence the effects of smoking, alcohol, physical activity, and obesity on mortality? A prospective population study. Scand J Public Health 2004;32:250-256.
140. Schnohr P. En undersøgelse af tidligere idrætsmænd. Ugeskr Læger 1968;130:539-541.
141. Schnohr P. En undersøgelse af tidligere idrætsmænd. Tidskr Legemsøvelser 1968;2:32-37. (secondary publication)
142. Schnohr P. An investigation of previous athletes. J Sport Med Phys Fitness 1968;8:241-244. (secondary publication)
143. Schnohr P. Une investigation chez des anciens athletes. Bull Féd Int d'Educat Phys 1968;3-4:3-9.(secondary publication)
144. Schnohr P. Dansk motionskampagne - Eremitageløbet. Ugeskr Læger 1969; 131:1436.
145. Schnohr P, Survival rates of nasopharyngeal cancer in California.. A review of 516 cases from 1942 through 1965. Cancer 1970;25:1099-1106
146. Schnohr P. Longevity and causes of death in male athletic champions. Lancet 1971;ii;1364-1366.
147. Schnohr P. International teaching seminar in cardio-vascular epidemiology. Ugeskr Læger 1973;135:2713-2714.
148. Schnohr P. Et kardiovaskulært populationsstudie. Amager-kvindeundersøgelsen 1973. Ugeskr Læger 1976; 138:188-192.
149. Schnohr P. Blodtrykket hos københavnske kvinder 25 til 65 år gamle. Amager-kvindeundersøgelsen 1973. Ugeskr Læger 1976;138:192-196.
150. Schnohr P, Rasmussen F. Hearing in women survivors of myocardial infarction. Scand Audiol 1980;9:179-182.
151. Schnohr P, Jensen G, Lange P, Scharling H, Appleyard M. The Copehagen City Heart Study. Østerbroundersøgelsen. Tables with data from the third examination 1991-1994. Eur Heart J 2001;3 (suppl H):H1-H83.
152. Schnohr P, Parner J, Lange P. Mortality in joggers:population based study of 4658 men. BMJ 2000;321:602-603.
153. Schnohr P, Parner J, Lange P. Motionsløbere lever længere. Østerbroundersøgelsen. Ugeskr Læger 2001; 163:2633-2635 (secondary publication).
154. Schnohr P, Parner J, Lange P. Motionslöpare lever längre. Läkartidnningen 2001;98;3133-3134 (secondary publication).
155. Schnohr P, Jensen JS, Scharling H, Nordestgaard BG. Coronary heart disease risk factors ranked by importance for the individual and community. A 21 year follow-up of 12,000 men and women from The Copenhagen City Heart Study. Eur Heart J 2002;23:620-626.
156. Schnohr P, Scharling, Jensen JS. Changes in leisure-time physical activity and risk of death:An observational study of 7,000 men and women. Am J Epidemiol 2003;158:639-644.
157. Schnohr P, Kristensen TS, Prescott E, Scharling H. Stress and life dissatisfaction are inversely associated with jogging and other types of physical activity in leisure time - The Copenhagen City Heart Study. Scand J Med Sci Sports 2005;15:107-112.
158. Schnohr P, Grønbæk M, Petersen L, Hein HO, Sørensen TIA. Physical activity in leisure time and risk of cancer:14-year follow-up of 28,000 Danish men and women. Scand I Publich Health 2005; 33:244-249.
159. Schnohr P, Lange P, Scharling H, Jensen JS. Long-term physical activity in leisure time and mortality from coronary heart disease, stroke, repiratory diseases, and cancer. The Copenhagen City Heart Study. Eur J Cardiovasc Prev Rehabil 2006;13:173-179.
160. Schnohr P, Scharling H, Jensen JS. Intensity versus duration of walking: Impact on mortality:the Copenhagen City Heart Study. Eur J Cardiovasc Prev Rehabil 2007;14:172-178.
161. Scully D, Kremer J, Meade MM, Graham R, Dudgeon K. Physical exercise and psychological well being: a critical review. Br J Sports Med 1998;32: 111-120.
162. Shepard RJ. Absolute versus relative intensity of physical activity in a doseresponse context. Med Sci Sports Exerc 2001;33:S400-S418.
163. Sherman SE, D'Agostino RB, Cobb JL, Kannel WB. Physical activity and mortality in women in the Framingham Heart Study. Am Heart J 1994; 128:879-884.
164. Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med 1984;311:874-877.
165. Smith GD, Shipley MJ, Batty GD, Morris JN, Marmot M. Physical activity and cause-specific mortality in the Whitehall study. Public Health 2000; 114:308-315.
166. Stefanick ML, Mackey S, Sheehan M, Ellsworth N, Haskell WL, Wood PD. Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. N Engl J Med 1998;339:12-20.
167. Stensvold I, Urdal P, Thürmer H, Tverdal A, Lund-Larsen PG, Foss OP. High-density lipoprotein cholesterol and coronary, cardiovascular and all cause mortality among middle-aged Norwegian men and women. Eur Heart J 1992;13:1155-1163.
168. Szymanski LM, Pate RR. Effects of exercise intensity, duration, and time of day on fibrinolytic activity in physically active men. Med Sci Sports Exerc 1994;26:1102-1108.
169. Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chron Dis 1978;31:741-755.
170. Thomsen TF, Davidsen M, Ibsen H, Jørgensen T, Jensen G, Borch-Johnsen K. A new method for CHD prediction and prevention based on regional risk scores and randomized clinical trials; PRECARD and the Copenhagen Risk Score. J Cardiovasc Risk 2001;8:291-297.
171. Thompson PD, Stern MP, Williams P, Duncan K, Haskell WL, Wood PD. Death during jogging or running. JAMA 1979;242:1265-1267.
172. Thompson PD, Funk EJ, Carleton RA, Sturner WQ. Incidence of death during jogging in Rhode Island from 1975 through 1980. JAMA 1982;247: 2535-2538.
173. Tibblin G. A population study of 50-year-old Men. An analysis of the non-participating group. Acta Med Scand 1965;178:453-459.
174. Trolle-Lagerros Y, Mucci LA, Kumle M, Braaten T, Weiderpass E, Hsieh C-C, Sandin S, Lagiou P, Trichopoulos D, Lund E, Adami H-O. Physical activity as a determinant of mortality in women. Epidemiology 2005;16:780-785.
175. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-1350.
176. Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H. Leisure activities and the risk of dementia in the elderly. N Engl J Med 2003;348:2508-2516.
177. Videbæk J, Madsen M. Heart statistics 2004. Danish Heart Foundation and National Institute of Public Health
178. Waller FB, Roberts Wc. Sudden death while running in conditioned runners aged 40 years or over. Am J Cardiol 1980;45:1292-1300.
179. Walsh J. Translation of Galen's Exhortatio ad Artes Addiscendas. Medical Life 1930;37:507-529.
180. Wannamethee SG, Shaper AG, Walker M. Changes in physical activity, mortality, incidence of coronary heart disease in older men. Lancet 1998;351: 1603-1608.
181. Wesslén L, Påhlson C, Lindquist O, Hjelm E, Gnarpe J, Larsson E, Baandrup U, Eriksson L, Fohlman J, Engstrand L, Linglöf T, Nyström-Rosander C, Gnarpe H, Magnius L, Rolf C, Friman G. An increase in sudden unexpected cardiac deaths among young Swedish orienteers during 1979-1992. Eur Heart J 1996;17:902-910.
182. Weuve J, Kang JH, Manson JE JE, Breteler MMB, Ware JH, Grodstein F. Physical activity, including walking and cognitive function in older women. JAMA 2004;292:1454-1461.
183. Weyerer S, Kupfer B. Physical exercise and psychological health. Sports Med 1994;17:108-116.
184. Whang W, Manson JE, Hu FB, Chae CU, Rexrode KM, Willett WC, Stampfer MJ, Albert CM. Physical exertion, exercise, and sudden cardiac death in women. JAMA 2006;295:1399-1403.
185. Wilhelmsen L, Tibblin G, Aurell M, Bjure J, Ekström-Jodal B, Grimby G. Physical activity, physical fitness and risk of myocardial infarction. Adv Cardiol 1976;18:217-230.
186. Williams RS, Logue EE, Lewis JL, Barton T, Stead NW, Wallace AG, Pizzo SV. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N Engl J Med 1980;302:987-991.
187. Yasin S, Alderson MR, Marr JW, Pattison DC, Morris JN. Assessment of habitual physical activity apart from occupation. Brit J Prev Soc Med 1967;21:163-169
188. Yu S, Yarnell JWG, Sweetnam PM, Murray L. What level of physical activity protects against premature cardiovascular death? The Caerphilly study. Heart 2003;89:502-506.
189. Østergård T, Nyholm B, Hansen TK, Rasmussen LM, Ingerslev J, Sørensen KE, Bøtker HE, Saltin B, Schmitz O. Endothelial function and biochemical vascular markers in first-degree relatives of type 2 diabetic patients: the effect of exercise training. Metabolism Clincal and Experimental 2006; 55:1508-1515.
190. Åstrand P-O, Rodahl K eds. Textbook of work physiology. McGraw-Hill Book Company, 1970.