A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab

Modern Rheumatology

Volumn 19, Issue 2, 2009, Pages 199-203

  Sugiura, Fumiaki ^a   Kojima, Toshihisa ^b   Oguchi, Takeshi ^a   Urata, Shirou ^a   Yuzawa, Yukio ^b   Sakakibara, Akihiro ^b   Hayashi, Hiroki ^b   Nishimoto, Norihiro ^c   Ishiguro, Naoki ^b  

^a ANJO KOSEI HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Peripheral neuropathy; Rheumatoid arthritis; Skin ulcer; Tocilizumab

Indexed keywords

ATLIZUMAB; C REACTIVE PROTEIN; CARBAMAZEPINE; INTERLEUKIN 6; METHOTREXATE; METHYLPREDNISOLONE; PREDNISOLONE; PROSTAVASIN; STEROID; SULFADIAZINE; VASCULOTROPIN;

AGED; ARTICLE; CASE REPORT; CLINICAL TRIAL; COLD SENSATION; CREATININE CLEARANCE; CYANOSIS; DEBRIDEMENT; DISEASE ACTIVITY; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG PULSE THERAPY; DRUG WITHDRAWAL; FEMALE; GRANULATION TISSUE; HUMAN; HUMAN TISSUE; JOINT SWELLING; KIDNEY DYSFUNCTION; KNEE PAIN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PURPURA; RHEUMATOID ARTHRITIS; SINGLE DRUG DOSE; SKIN BIOPSY; SKIN NECROSIS; SKIN PAIN; SKIN ULCER; SPONDYLOSIS; WOUND CARE;

AGED; ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; BLOOD PLATELETS; C-REACTIVE PROTEIN; FEMALE; FIBRINOGEN; HUMANS; INTERLEUKIN-6; NECROSIS; PERIPHERAL NERVOUS SYSTEM DISEASES; SKIN ULCER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 64449088500     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-008-0132-2     Document Type: Article

References (11)

1. Nishimoto N. Interleukin-6 in rheumatoid arthritis. Curr Opin Rheumatol. 2006;18:277-81.
2. Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 2004;50:1761-9.
3. Maini RN, Taylor PC, Szechinski J, Pavelka K, Bröll J, Balint G, et al. for the CHARISMA study group. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 2006;54:2817-29.
4. Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an X-ray reader-blinded randomized controlled trial of tocilizumab. Ann Rheum Dis. 2007;66:1162-7.
5. Ogawa J, Harigai M, Akashi T, Nagasaka K, Suzuki F, Tominaga S, et al. Exacerbation of chronic active Epstein-Barr virus infection in a patient with rheumatoid arthritis receiving humanized anti-interleukin-6 receptor monoclonal antibody. Ann Rheum Dis. 2006;65:1667-9.
6. Viac J, Pernet I, Schmitt D, Claudy A. Overexpression of circulating vascular endothelial growth factor (VEGF) in leukocytoclastic vasculitis. Arch Dermatol Res. 1999;291:622-3.
7. Jarrett SJ, Cunnane G, Conaghan PG, Bingham SJ, Buch MH, Quinn MA, et al. Anti-tumor necrosis factor-α therapy-induced vasculitis: Case series. J Rheumatol. 2003;30:2287-91.
8. Saint Marcoux B, De Bandtl M. On behalf of the CRI (club rhumatismes et inflammation). Vasculitides induced by TNFα antagonists: A study in 39 patients in France. Joint Bone Spine. 2006;73:710-3.
9. Richette P, Dieudé P, Damiano J, Lioté F, Orcel P, Bardin T. Sensory neuropathy revealing necrotizing vasculitis during Infliximab therapy for rheumatoid arthritis. J Rheumatol. 2004;31:2079-81.
10. Mohan N, Edwards ET, Cupps TR, Slifman N, Lee J, Siegel JN, et al. Leukocytoclastic vasculitis associated with tumor necrosis factor-alpha blocking agents. J Rheumatol. 2004;31:1955-8.
11. Tamm M, Bihl M, Eickelberg O, Stulz P, Perruchoud AP, Roth M. Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells. Am J Respir Cell Mol Biol. 1998;19:653-61.