Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetaseby adenylate analogs

Biochimie

Volumn 91, Issue 5, 2009, Pages 596-603

  Messmer, Marie ^a   Blais, Sébastien P ^b   Balg, Christian ^b   Chênevert, Robert ^b   Grenier, Luc ^b   Lagüe, Patrick ^b   Sauter, Claude ^a   Sissler, Marie ^a   Giegé, Richard ^a   Lapointe, Jacques ^b   Florentz, Catherine ^a  

^a INST DE BIOL MOLEC ET CELLULAIRE   (France)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Adenylate analogs; Aspartyl tRNA synthetase; Human mitochondria; Inhibition; Molecular docking

Indexed keywords

5' O (N ASPARTYLSULFAMOYL)ADENOSINE; ADENOSINE DERIVATIVE; ASPARTATE TRANSFER RNA LIGASE; ASPARTOLADENYLATE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; NONHUMAN; PSEUDOMONAS AERUGINOSA;

ADENOSINE MONOPHOSPHATE; ANIMALS; ASPARTATE-TRNA LIGASE; CATALYTIC DOMAIN; CATTLE; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); BOVINAE; ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; PSEUDOMONAS AERUGINOSA;

EID: 64449088136     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2009.02.005     Document Type: Article

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