Transient inhibition of foot-and-mouth disease virus replication by siRNAs silencing VP1 protein coding region

Research in Veterinary Science

Volumn 86, Issue 3, 2009, Pages 443-452

  Lv, Ke ^a   Guo, Yingjun ^a   Zhang, Yiliang ^a   Wang, Kaiyu ^a   Li, Ka ^a   Zhu, Yan ^a   Sun, Shuhan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Flow cytometry; Foot and mouth disease virus; Real time quantitative PCR; Small interfering RNA; T7 RNA polymerase

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; NUCLEOTIDE; PROTEIN VP1; RNA POLYMERASE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; ASSAY; CELL STRAIN BHK; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DESIGN; FOOT AND MOUTH DISEASE VIRUS; GENE SEQUENCE; GENETIC TRANSFECTION; HAND FOOT AND MOUTH DISEASE; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POSTTRANSCRIPTIONAL GENE SILENCING; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; VIRUS REPLICATION; VIRUS TITRATION; VIRUS VIABILITY;

ANIMALS; CAPSID PROTEINS; CATTLE; CATTLE DISEASES; CELL LINE; DNA PRIMERS; DNA, VIRAL; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; GENES, REPORTER; GOAT DISEASES; GOATS; HUMANS; KIDNEY; PLASMIDS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SHEEP; SHEEP DISEASES; SWINE; SWINE DISEASES; VIRUS REPLICATION;

ANIMALIA; FOOT-AND-MOUTH DISEASE VIRUS;

EID: 64449085557     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2008.10.011     Document Type: Article

References (38)

1. Akerstrom S., Mirazimi A., and Tan Y.J. Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S. Antiviral Res. 73 3 (2007) 219-227
2. Balamurugan V., Kumar R.M., and Suryanarayana V.V. Past and present vaccine development strategies for the control of foot-and-mouth disease. Acta Virol. 48 4 (2004) 201-214
3. Belsham G.J. Translation and replication of FMDV RNA. Curr. Top. Microbiol. Immunol. 288 (2005) 43-70
4. Bennasser Y., Yeung M.L., and Jeang K.T. RNAi therapy for HIV infection: principles and practicalities. BioDrugs 21 1 (2007) 17-22
5. Betz N. Produce functional siRNAs and hairpin siRNAs using the T7 RiboMAX™ express RNAi system. Promega Notes 85 (2003) 15-18
6. Brass A.L., Dykxhoorn D.M., Benita Y., Yan N., Engelman A., Xavier R.J., Lieberman J., and Elledge S.J. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319 5865 (2008) 921-926
7. Chen S.P., Sun Y.F., Lee M.C., Cheng I.C., Yang P.C., Huang T.S., Jong M.H., Robertson I.D., Edwards J.R., and Ellis T.M. Immune responses to foot-and-mouth disease virus in pig farms after the 1997 outbreak in Taiwan. Vet Microbiol 126 1-3 (2007) 82-90
8. Chen W., Liu M., Jiao Y., Yan W., Wei X., Chen J., Fei L., Liu Y., Zuo X., Yang F., Lu Y., and Zheng Z. Adenovirus-mediated RNA interference against foot-and-mouth disease virus infection both in vitro and in vivo. J. Virol. 80 7 (2006) 3559-3566
9. Chen W., Yan W., Du Q., Fei L., Liu M., Ni Z., Sheng Z., and Zheng Z. RNA interference targeting VP1 inhibits foot-and-mouth disease virus replication in BHK-21 cells and suckling mice. J. Virol. 78 13 (2004) 6900-6907
10. Cogoni C., and Macino G. Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa. Proc. Natl. Acad. Sci. USA 94 19 (1997) 10233-10238
11. de los Santos T., Wu Q., a Botton S., and Grubman M.J. Short hairpin RNA targeted to the highly conserved 2B nonstructural protein coding region inhibits replication of multiple serotypes of foot-and-mouth disease virus. Virology 335 2 (2005) 222-231
12. DeVincenzo J., Cehelsky J.E., Alvarez R., Elbashir S., Harborth J., Toudjarska I., Nechev L., Murugaiah V., Van Vliet A., Vaishnaw A.K., and Meyers R. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res. 77 3 (2008) 225-231
13. Donze O., and Picard D. RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Res. 30 10 (2002) e46
14. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 6669 (1998) 806-811
15. Giering J.C., Grimm D., Storm T.A., and Kay M.A. Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Mol. Ther. 16 9 (2008) 1630-1636
16. Gitlin L., Stone J.K., and Andino R. Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches. J. Virol. 79 2 (2005) 1027-1035
17. Grubman M.J., and de los Santos T. Rapid control of foot-and-mouth disease outbreaks: is RNAi a possible solution?. Trends Immunol. 26 2 (2005) 65-68
18. Haydon D.T., Kao R.R., and Kitching R.P. The UK foot-and-mouth disease outbreak - the aftermath. Nat. Rev. Microbiol. 2 8 (2004) 675-681
19. Kahana R., Kuznetzova L., Rogel A., Shemesh M., Hai D., Yadin H., and Stram Y. Inhibition of foot-and-mouth disease virus replication by small interfering RNA. J. Gen. Virol. 85 Pt 11 (2004) 3213-3217
20. Kim Y.H., Lee J.H., Paik N.W., and Rho H.M. RNAi-based knockdown of HBx mRNA in HBx-transformed and HBV-producing human liver cells. DNA Cell Biol. 25 7 (2006) 412-417
21. Manjunath N., Kumar P., Lee S.K., and Shankar P. Interfering antiviral immunity: application, subversion, hope?. Trends Immunol. 27 7 (2006) 328-335
22. Mason P.W., Grubman M.J., and Baxt B. Molecular basis of pathogenesis of FMDV. Virus Res. 91 1 (2003) 9-32
23. Meyers, R.E., Alvarez, R., Tripp, R., Hadwiger, P., Constein, R., Elbashir, S.J.M., Borland, T., Toudjarska, I., DeVincenzo, J., 2007. ALN-RSV01, an RNAi therapeutic for the treatment of respiratory syncytial virus (RSV) infection. E-PAS, 616295.616212.
24. Mohapatra J.K., Sanyal A., Hemadri D., Tosh C., Kumar R.M., and Bandyopadhyay S.K. Evaluation of in vitro inhibitory potential of small interfering RNAs directed against various regions of foot-and-mouth disease virus genome. Biochem. Biophys. Res. Commun. 329 3 (2005) 1133-1138
25. Napoli C., Lemieux C., and Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2 4 (1990) 279-289
26. Nekhai S., and Jerebtsova M. Therapies for HIV with RNAi. Curr. Opin. Mol. Ther. 8 1 (2006) 52-61
27. Qin Z.L., Zhao P., Zhang X.L., Yu J.G., Cao M.M., Zhao L.J., Luan J., and Qi Z.T. Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cells. Biochem. Biophys. Res. Commun. 324 4 (2004) 1186-1193
28. Radhakrishnan S.K., Layden T.J., and Gartel A.L. RNA interference as a new strategy against viral hepatitis. Virology 323 2 (2004) 173-181
29. Reed L.J., and Muench H.A. A simple method of estimating fifty percent end points. Am. J. Hyg. 27 (1938) 493-497
30. Rendall G. Progress toward the therapy of hepatitis with RNAi. Hepatology 41 6 (2005) 1220-1222
31. Saiz M., Nunez J.I., Jimenez-Clavero M.A., Baranowski E., and Sobrino F. Foot-and-mouth disease virus: biology and prospects for disease control. Microbes Infect 4 11 (2002) 1183-1192
32. Shih S.R., Ho M.S., Lin K.H., Wu S.L., Chen Y.T., Wu C.N., Lin T.Y., Chang L.Y., Tsao K.C., Ning H.C., Chang P.Y., Jung S.M., Hsueh C., and Chang K.S. Genetic analysis of enterovirus 71 isolated from fatal, non-fatal cases of hand, foot, mouth disease during an epidemic in Taiwan, 1998. Virus Res. 68 2 (2000) 127-136
33. Thompson D., Muriel P., Russell D., Osborne P., Bromley A., Rowland M., Creigh-Tyte S., and Brown C. Economic costs of the foot, mouth disease outbreak in the United Kingdom in 2001. Rev. Sci. Technol. 21 3 (2002) 675-687
34. Van Rensburg H.G., and Mason P.W. Construction and evaluation of a recombinant foot-and-mouth disease virus: implications for inactivated vaccine production. Ann. NY Acad. Sci. 969 (2002) 83-87
35. van Rij R.P., and Andino R. The silent treatment: RNAi as a defense against virus infection in mammals. Trends Biotechnol. 24 4 (2006) 186-193
36. Ward G., Rieder E., and Mason P.W. Plasmid DNA encoding replicating foot-and-mouth disease virus genomes induces antiviral immune responses in swine. J. Virol. 71 10 (1997) 7442-7447
37. Westerhout E.M., Ooms M., Vink M., Das A.T., and Berkhout B. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res. 33 2 (2005) 796-804
38. Wu C.J., Huang H.W., Liu C.Y., Hong C.F., and Chan Y.L. Inhibition of SARS-CoV replication by siRNA. Antiviral Res. 65 1 (2005) 45-48