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This drawback can be clearly seen, for example, from the epothilone case; cf. discussion in ref 7a-c.
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(k) For a short review on alkyne metathesis in natural product chemistry, see: Lindel, T. In Organic Synthesis Highlights V; Schmaltz, H.-G., Wirth, T., Eds.; Wiley-VCH: Weinheim, Germany, 2003; pp 27-35.
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and ref 7e
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6-activator systems under microwave irradiation, see: Villemin, D.; Héroux, M.; Blot, V. Tetrahedron Lett. 2001, 42, 3701-3703 and ref 7e.
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6444239552
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note
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a program for 25 °C and zero ionic strength in aqueous solutions (Advanced Chemistry Development, Inc., 90 Adelaide Street West, Suite 600 Toronto, Ontario M5H 3V9, Canada).
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-
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61
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6444224562
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note
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See the Supporting Information for experimental details.
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65
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0034697702
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(b) Note that approach for keramaphidin C and manzamine C based on conventional diene RCM, though efficient in chemical terms, mainly afforded the unnatural (E)-isomer, see: Arisawa, M.; Kato, C.; Kaneko, H.; Nishida, A.; Nakagawa, M. J. Chem. Soc., Perkin Trans. 1 2000, 1873-1876.
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66
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6444220956
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note
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For a similar example, see ref 7f.
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