Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc

Journal of Physiology

Volumn 560, Issue 1, 2004, Pages 51-62

  Clarke, Catherine E ^a   Veale, Emma L ^a   Green, Paula J ^b   Meadows, Helen J ^b   Mathie, Alistair ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; COMPLEMENTARY DNA; GLUTAMIC ACID; HISTIDINE; LYSINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; TANDEM PORE DOMAIN POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; ZINC CHLORIDE; CALCIUM ION; SODIUM ION; TASK 1 CHANNEL; TASK 2 CHANNEL; TASK 3 CHANNEL; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN NERVE CELL; CEREBELLUM CORTEX; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SELECTIVITY; FEMALE; GENE MUTATION; GRANULE CELL; HUMAN; IC 50; MALE; NERVE CELL MEMBRANE POTENTIAL; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PH MEASUREMENT; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; REVERTANT; SENSITIVITY ANALYSIS; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; ACIDIFICATION; CEREBELLAR GRANULE NEURON; CONCENTRATION RESPONSE; EFFECTIVE CONCENTRATION; EXCITABILITY; IC50; IKSO CURRENT; ION PERMEABILITY; MEMBRANE STEADY POTENTIAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; REVERSAL POTENTIAL; XENOPUS LAEVIS;

ANIMALS; CALCIUM; CEREBELLUM; HISTIDINE; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; NERVE TISSUE PROTEINS; NEURONS; OOCYTES; POTASSIUM; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN STRUCTURE, TERTIARY; XENOPUS; ZINC;

EID: 6444219991     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.070292     Document Type: Article

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