α-Phosphonosulfonic acids: Potent and selective inhibitors of squalene synthase

Journal of Medicinal Chemistry

Volumn 39, Issue 3, 1996, Pages 657-660

  Magnin, D R ^a   Biller, S A ^a   Chen, Y ^a   Dickson Jr , J K ^a   Fryszman, O M ^a   Lawrence, R M ^a   Logan, J V H ^a   Sieber McMaster, E S ^a   Sulsky, R B ^a   Traeger, S C ^a   Hsieh, D C ^a   Lan, S J ^a   Rinehart, J K ^a   Harrity, T W ^a   Jolibois, K G ^a   Kunselman, L K ^a   Rich, L C ^a   Slusarchyk, D A ^a   Ciosek Jr , C P ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA PHOSPHONOSULFONIC ACID DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CHOLESTEROL SYNTHESIS; DRUG BIOAVAILABILITY; DRUG INHIBITION; ENZYME INHIBITION; LIVER TOXICITY;

ANIMALS; ANTILIPEMIC AGENTS; CHOLESTEROL; CRICETINAE; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; MICROSOMES, LIVER; MOLECULAR CONFORMATION; RATS; SULFONIC ACIDS;

EID: 19244368781     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9507340     Document Type: Article

References (0)