Enantioselective synthesis of α-phosphono sulfonate squalene synthase inhibitors: Chiral recognition in the interactions of an α-phosphono sulfonate inhibitor with squalene synthase

Journal of the American Chemical Society

Volumn 118, Issue 46, 1996, Pages 11668-11669

  Lawrence, R Michael ^a   Biller, Scott A ^a   Dickson Jr , John K ^a   Logan, Janette V H ^a   Magnin, David R ^a   Sulsky, Richard B ^a   DiMarco, John D ^a   Gougoutas, Jack Z ^a   Beyer, Barbara D ^a   Taylor, Susan C ^a   Lan, Shih Jung ^a   Ciosek Jr , Carl P ^a   Harrity, Thomas W ^a   Jolibois, Kern G ^a   Kunselman, Lori K ^a   Slusarchyk, Dorothy A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; LIVER MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 10544241192     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja962505o     Document Type: Article

References (24)

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2. For reviews on squalene synthase inhibitors, see: Biller, S. A.; Neuenschwander, K.; Ponpipom, M. M.; Poulter, C. D. Curr. Pharm. Des. 1996, 2, 1-40. Abe, A.; Tomesch, J. C.; Wattanasain, S.; Prestwich, G. D. Nat. Prod. Rep. 1994, 279-302.
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