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Volumn 16, Issue 10, 2006, Pages 2693-2698

Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus

Author keywords

Antiviral candidates; Bitriazolyl compounds; Huisgen 1,3 cyclcoaddition; Tobacco mosaic virus; Triazoles

Indexed keywords

ANTIVIRUS AGENT; RIBAVIRIN; TRIAZOLE DERIVATIVE;

EID: 33645885314     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.023     Document Type: Article
Times cited : (64)

References (23)
  • 9
    • 33645872330 scopus 로고    scopus 로고
    • note
    • -.
  • 10
    • 33645870931 scopus 로고    scopus 로고
    • note
    • 2)/3]. The X-ray structure data have been deposited in the Cambridge Crystallographic Data Center with deposition No. CCDC 297233. Copy of the data can be obtained, free of charge, on application to the CCDC, 12 Union Road, Cambridge CB2 1EZ UK (e-mail: deposit@ccdc.cam.ac.uk).
  • 12
    • 33645871536 scopus 로고    scopus 로고
    • note
    • -.
  • 14
    • 33645895817 scopus 로고    scopus 로고
    • note
    • -2 μg/mL. Then, the two separated half leaves were cultured at 25 °C for 72 h. Standard of 2,4-dioxohexahydro-1,3,5-triazine (DHT) and ribavirin were used as control. All treatments were repeated for three times at least. The inhibition percentage was calculated by comparing the average numbers of the viral inflammations on the two halves of leaves according to Formula 1.{A formula is presented}where Y is the antiviral inhibition percentage (%); CK is the average numbers of viral inflammations of the leaf treated with double distilled water; A is the average numbers of viral inflammations of the treated half leaf by title compound. The effects of direct antiviral activity were divided into four levels: excellent, Y > 50%; good, Y: 50-30%; bad, Y: 20-30%; no activity, Y < 20%.
  • 17
    • 33645872655 scopus 로고    scopus 로고
    • Ribavirin is a reference standard used in our laboratories for more than 10 years and its average inhibition against TMV is around 50%.
  • 20
    • 33645887176 scopus 로고    scopus 로고
    • note
    • -2 μg/mL was inoculated 7 days later in the top leaf which has grown after the compound application. Each experiment was repeated for five times, while the double distilled water and acibenzolar-S-methyl (BTH) were used as reference control of standard plant activator. The treated tobacco plant was placed at 25 °C for 72 h of cultivation. The induction activity of antiviral efficacy was calculated by comparing the average numbers of the viral inflammations on the top leaf with corresponding control according to the following Formula 2:{A formula is presented}where I is the activities of systemic acquired resistance (%); CK is the average numbers of viral inflammations of control leaves; T is the average numbers of viral inflammations of the inoculated leaves. The induction activities of systemic acquired resistance were divided into four levels: excellent, I > 70%; good, I: 50-70%; bad, I: 30-50%; no induction activity, I < 30%.
  • 22
    • 33645843854 scopus 로고    scopus 로고
    • Introduction about two prediction programs is published in the website: .
  • 23
    • 33645889598 scopus 로고    scopus 로고
    • note
    • The accuracy of the prediction model in carcinogenic toxicity is about 84% and that in mutagenic toxicity is about 85%. For the results of PSCT, if the predictability is greater than 70%, non-toxicity is greater than 0.65 and toxicity is less than non-toxicity, the compound is not carcinogenic and its reliability is about 85%. For PSMT, if the predictability is greater than 80% and toxicity is less than non-toxicity, the compound is not mutagenic and its reliability is about 84%.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.