Quasispecies, error catastrophe, and the antiviral activity of ribavirin

Virology

Volumn 298, Issue 2, 2002, Pages 175-180

  Graci, Jason D ^a   Cameron, Craig E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PIRAZOFURIN; RIBAVIRIN;

ANTIVIRAL ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; RNA VIRUS; SHORT SURVEY; VIRUS GENOME;

RNA VIRUSES;

EID: 0036376657     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1487     Document Type: Article

References (34)

1. Molecular approaches for the treatment of hemorrhagic fever virus infections
2. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub)
3. Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C
4. Clinical, biological, and biochemical effect of pyrazofurin
5. RNA virus error catastrophe: Direct molecular test by using ribavirin
6. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
7. Interferon and ribavirin vs interferon alone in the re-treatment of chronic hepatitis C previously nonresponsive to interferon: A meta-analysis of randomized trials
8. Antiviral agents: Characteristic activity spectrum depending on the molecular target with which they interact
9. Combination of interferon and ribavirin in chronic hepatitis C: Re-treatment of nonresponders to interferon
10. Pyrazofurin metabolism, enzyme inhibition, and resistance in L5178Y cells
11. Quasispecies theory in virology
12. The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: Biological relevance - A review
13. Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate
14. Ribavirin enhancement of hepatitis C virus core antigen-specific type 1 T helper cell response correlates with the increased IL-12 level
15. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis
16. Is the quasispecies concept relevant to RNA viruses?
17. Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug
18. Respiratory syncytial virus: Update on infection, treatment, and prevention
19. Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes
20. Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues
21. Survey and summary: The applications of universal DNA base analogues
22. Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs
23. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin
24. Highly efficient random mutagenesis in transcription-reverse-transcription cycles by a hydrogen bond ambivalent nucleoside 5′-triphosphate analogue: Potential candidates for a selective anti-retroviral therapy
25. Virazole (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide): A cytostatic agent
26. Efficient virus extinction by combinations of a mutagen and antiviral inhibitors
27. Antiviral action and selectivity of 6-azauridine
28. Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1
29. Broad-spectrum antiviral activity of virazole: 1-Beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
30. Mechanism of action of 1-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent
31. Physiological concentrations of purines and pyrimidines
32. Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides
33. Metabolism of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide and related five-membered heterocycles to 5′-triphosphates in human blood and L5178Y cells
34. The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection