Endothelin-converting enzyme-1 increases in atherosclerotic mice: Potential role of oxidized low density lipoproteins

Journal of Lipid Research

Volumn 50, Issue 3, 2009, Pages 364-375

  Martínez Miguel, Patricia ^a   Raoch, Viviana ^a   Zaragoza, Carlos ^c   Valdivielso, Jose Manuel ^d   Rodríguez Puyol, Manuel ^b   Rodríguez Puyol, Diego ^a,b   López Ongil, Susana ^a  

^a HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

Author keywords

Endothelial function; Hypercholesterolemia; Hypertension

Indexed keywords

5,6,8,13 TETRAHYDRO 1,6,9,14 TETRAHYDROXY 3 (2 HYDROXYPROPYL) 7 METHOXY 8,13 DIOXOBENZO[A]NAPHTHACENE 2 CARBOXYLIC ACID; APOLIPOPROTEIN E; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; ASPARTIC PROTEINASE; DNA; ENDOTHELIN-CONVERTING ENZYME 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METALLOPROTEINASE; OLR1 PROTEIN, HUMAN; OLR1 PROTEIN, MOUSE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; C57BL 6 MOUSE; CLINICAL ARTICLE; CONTROLLED STUDY; COW; DIETARY INTAKE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; KIDNEY; LIPID DIET; LIPOPROTEIN DEFICIENCY; LIPOPROTEIN METABOLISM; LUNG; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VASCULAR ENDOTHELIUM; WILD TYPE; ANIMAL; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; CATTLE; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MIDDLE AGED; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; UPREGULATION;

AGED; ANIMALS; APOLIPOPROTEINS E; ASPARTIC ENDOPEPTIDASES; ATHEROSCLEROSIS; BASE SEQUENCE; CATTLE; CELLS, CULTURED; DNA; ENDOTHELIAL CELLS; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; MALE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS E; UP-REGULATION;

EID: 64349099108     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800215-JLR200     Document Type: Article

References (44)

1. Berliner, J. A., M. Navab, A. M. Fogelman, J. S. Frank, L. L. Demer, P. A. Edwards, A. D. Watson, and A. J. Lusis. 1995. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. 91: 2488-2496.
2. Lusis, A. J. 2000. Atherosclerosis. Nature. 407: 233-241.
3. Rao, R. M., L. Yang, G. Garcia-Cardena, and F. W. Luscinskas. 2007. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ. Res. 101: 234-247.
4. Hansson, G. K., A. K. Robertson, and C. Söderberg-Nauclér. 2006. Inflammation and atherosclerosis. Annu. Rev. Pathol.1: 297-329.
5. Stocker, R., and J. F. Keaney. 2004. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84: 1381-1478.
6. Morawietz, H., N. Duerrschmidt, B. Niemann, J. Galle, T. Sawamura, and J. Holtz. 2001. Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells. Biochem. Biophys. Res. Commun. 284: 961-965.
7. Cominacini, L., A. F. Pasini, U. Garbin, A. Davoli, M. L. Tosetti, M. Campagnola, A. Rigoni, A. M. Pastorino, V. Lo Cascio, and T. Sawamura. 2000. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NFkB through an increased production of intracellular reactive oxygen species. J. Biol. Chem. 275: 12633-12638.
8. Natarajan, R., M. A. Reddy, K. U. Malik, S. Fatima, and B. V. Khan. 2001. Signaling mechanisms of nuclear factor-kappab-mediated activation of inflammatory genes by 13-hydroperoxyoctadecadienoic acid in cultured vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 21: 1408-1413.
9. Selwyn, A. P., S. Kinlay, P. Libby, and P. Ganz. 1997. Atherogenic lipids, vascular dysfunction, and clinical signs of ischemic heart disease. Circulation. 95: 5-7.
10. Endemann, D. H., and E. L. Schiffrin. 2004. Endothelial dysfunction. J. Am. Soc. Nephrol. 15: 1983-1992.
11. Landmesser, U., B. Horning, and H. Drexler. 2004. Endothelial function: a critical determinant in atherosclerosis? Circulation. 109: II27-II33.
12. Fan, J., H. Unoki, S. Iwasa, and T. Watanabe. 2000. Role of endothelin-1 in atherosclerosis. Ann. N. Y. Acad. Sci. 902: 84-94.
13. Rossi, G. P., S. Colonna, E. Pavan, G. Albertin, F. Della Rocca, G. Gerosa, D. Casarotto, S. Sartore, P. Pauletto, and A. C. Pessina. 19 9. Endothelin-1 and its mRNA in the wall layers of human arteries ex vivo. Circulation. 99: 1147-1155.
14. Cardillo, C., C. M. Kilcoyne, R. O. Cannon, and J. A. Panza. 2000. Increased activity of endogenous endothelin in patients with hypercholesterolemia. J. Am. Coll. Cardiol. 36: 1483-1488.
15. d'Uscio, L. V., M. Barton, S. Shaw, and T. F. Lüscher. 2002. Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice. Cardiovasc. Res. 53: 487-495.
16. Barton, M., C. C. Haudenschild, L. V. d'Uscio, S. Shaw, K. Munter, and T. F. Lüscher. 1998. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc. Natl. Acad. Sci. USA. 95: 14367-14372.
17. Ihling, C., T. Szombathy, B. Bohrmann, M. Brockhaus, H. E. Schaefer, and B. M. Loeffler. 2001. Coexpression of ECE-1 and ET-1 in different stages of human atherosclerosis. Circulation. 104: 864-869.
18. Bohm, F., B. L. Johansson, U. Hedin, K. Alving, and J. Pernow. 2002. Enhanced vasoconstrictor effect of big-ET-1 in patients with atherosclerosis: relation to conversion to endothelin-1. Atherosclerosis. 160: 215-222.
19. Ruschitzka, F., U. Moehrlen, T. Quaschning, M. Lachat, G. Noll, S. Shaw, Z. Yang, D. Teupser, T. Subkowski, M. I. Turina, et al. 2000. Tissue endothelin-converting enzyme activity correlates with cardiovascular risk factors in coronary artery disease. Circulation. 102: 1086-1092.
20. Tan, M. S., Y. J. Lee, S. J. Shin, and J. H. Tsai. 1997. Oxidized low-density lipoprotein stimulates endothelin-1 release and mRNA expression from rat mesangial cells. J. Lab. Clin. Med. 129: 224-230.
21. Boulanger, C. M., F. C. Tanner, M. L. Bea, A. W. Hahn, A. Werner, and T. F. Lüscher. 1992. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ. Res. 70: 1191-1197.
22. Niemann, B., S. Rohrbach, R. A. Catar, G. Muller, M. Barton, and H. Morawietz. 2005. Native and oxidized low-density lipoproteins stimulate endothelin-converting enzyme-1 expression in human endothelial cells. Biochem. Biophys. Res. Commun. 334: 747-753.
23. Saura, M., C. Zaragoza, B. Herranz, M. Griera, L. Diez-Marqués, D. Rodríguez-Puyol, and M. Rodríguez-Puyol. 2005. Nitric oxide regulates transforming growth factor-beta signalling in endothelial cells. Circ. Res. 97: 1115-1123.
24. Shimada, K., Y. Matsushita, K. Wakabayashi, M. Takahashi, A. Matsubara, Y. Iijima, and K. Tanzawa. 1995. Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem. Biophys. Res. Commun. 207: 807-812.
25. Marsden, P. A., T. A. Brock, and B. J. Ballermann. 1990. Glomerular endothelial cells respond to calcium-mobilizing agonists with release of EDRF. Am. J. Physiol. 258: F1295-F1303.
26. Havel, R. J., H. A. Eder, and H. H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1345-1353.
27. Stanton, L. W., R. T. White, C. M. Bryant, A. A. Protter, and G. Endemann. 1992. A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein. J. Biol. Chem. 267: 22446-22451.
28. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal. Biochem. 162: 156-159.
29. González-Santiago, L., S. López-Ongil, C. Quereda, M. Rodríguez-Puyol, and D. Rodríguez-Puyol. 2000. Imbalance in endothelial vasoactive factors as a possible cause of cyclosporin toxicity: a role for endothelin-converting enzyme. J. Lab. Clin. Med. 136: 395-401.
30. López-Ongil, S., M. L. Diez-Marqués, M. Griera, M. Rodríguez-Puyol, and D. Rodríguez-Puyol. 2005. Crosstalk between mesangial and endothelial cells: angiotensin II down-regulates endothelin-converting enzyme-1. Cell Physiol. Biochem. 15: 135-144.
31. Lopez-Ongil, S., V. Senchak, M. Saura, C. Zaragoza, M. Ames, B. J. Ballermann, M. Rodríguez-Puyol, D. Rodríguez-Puyol, and C. J. Lowenstein. 2000. Superoxide regulation of endothelin converting enzyme. J. Biol. Chem. 275: 26423-26427.
32. Ohnaka, K., R. Takayanagi, T. Yamauchi, H. Okazaki, M. Ohashi, F. Umeda, and H. Nawata. 1990. Identification and characterization of endothelin-converting enzyme activity in cultured bovine endothelial cells. Biochem. Biophys. Res. Commun. 168: 1128-1136.
33. López-Ongil, S., M. Saura, C. Zaragoza, L. González-Santiago, M. Rodríguez-Puyol, C. J. Lowenstein, and D. Rodríguez-Puyol. 2002. Regulation of bovine endothelin-converting enzyme-1 by hydrogen peroxide. Free Radic. Biol. Med. 32: 406-413.
34. López-Ongil, S., O. Hernández-Perera, G. Pérez de Lema, S. Lamas, M. Rodríguez-Puyol, and D. Rodríguez-Puyol. 1998. Role of reactive oxygen species in the signaling cascade of Ciclosporine A-mediated up-regulation of NOS3 in vascular endothelial cells. Br. J. Pharmacol. 124: 447-454.
35. Valdenaire, O., E. Rohrbacher, and M. G. Mattei. 1995. Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). J. Biol. Chem. 270: 29794-29798.
36. Pérez-Rivero, G., M. P. Ruíz-Torres, J. V. Rivas-Elena, M. Jerkic, M. L. Díez-Marqués, J. M. López-Novoa, M. A. Blasco, and D. Rodríguez-Puyol. 2006. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation. 114: 309-317.
37. Mitani, H., M. Takimoto, T. Bandoh, and M. Kimura. 2000. Increases of vascular endothelin-converting enzyme activity and endothelin-1 level on atherosclerotic lesions in hyperlipidemic rabbits. Eur. J. Pharmacol. 387: 313-319.
38. Li, D., and J. L. Metha. 2005. Oxidized LDL, a critical factor in atherogenesis. Cardiovasc. Res. 68: 353-354.
39. Inoue, K., Y. Arai, H. Kurihara, T. Kita, and T. Sawamura. 2005. Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ. Res. 97: 176-184.
40. Mehta, J. L., J. Chen, P. L. Hermonat, F. Romeo, and G. Novelli. 2006. Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc. Res. 69: 36-45.
41. Li, D., and J. L. Metha. 2000. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler. Thromb. Vasc. Biol. 20: 1116-1122.
42. Li, D., and J. L. Metha. 2000. Antisense to LOX-1 inhibits oxidized LDL mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation. 101: 2889-2895.
43. Holvoet, P., J. Vanhaecke, S. Janssens, F. Van de Werf, and D. Collen. 1998. Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation. 98: 1487-1494.
44. Robbesyn, F., V. García, N. Auge, O. Vieira, M. F. Frisach, R. Salvayre, and A. Negre-Salvayre. 2003. HDL counterbalance the proinflammatory effect of oxidized LDL by inhibiting intracellular reactive oxygen species rise, proteasome activation, and subsequent NF-kappa B activation in smooth muscle cells. FASEB J. 17: 743-745.