Oxidized LDL, a critical factor in atherogenesis

Cardiovascular Research

Volumn 68, Issue 3, 2005, Pages 353-354

  Li, Dayuan ^a,b   Mehta, Jawahar L ^a  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN;

ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CYTOTOXICITY; DIABETES MELLITUS; DISEASE MARKER; DISEASE PREDISPOSITION; DRUG MECHANISM; EDITORIAL; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART MUSCLE ISCHEMIA; HUMAN; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RABBIT; SIGNAL TRANSDUCTION;

ANIMALS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; CHOLESTEROL; DNA-BINDING PROTEINS; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; HOMEOSTASIS; HUMANS; HYDROXYCHOLESTEROLS; LIPOPROTEINS, LDL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SCAVENGER RECEPTORS, CLASS E;

EID: 27644447314     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2005.09.009     Document Type: Editorial

References (17)

1. M.S. Brown, and J.L. Goldstein A receptor-mediated pathway for cholesterol homeostasis Science 232 1986 34 47
2. D. Steinberg Low density lipoprotein oxidation and its pathobiological significance J Biol Chem 272 1997 20963 20968
3. Y. Zhu, H. Liao, X. Xie, Y. Yuan, T.S. Lee, and N. Wang Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR) Cardiovasc Res 68 2005 425 432
4. D. Li, and J.L. Mehta Antisense to endothelial ox-LDL receptor LOX-1 inhibits ox-LDL-mediated upregulation of MCP-1 expression and monocyte adhesion to human coronary artery endothelial cells Circulation 101 2000 2889 2896
5. L. Cominacini, A.F. Pasini, U. Garbin, A. Davoli, M.L. Tosetti, and M. Campagnola Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species J Biol Chem 28 275 2000 12633 12638
6. D. Li, and J.L. Mehta Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors Arterioscler Thromb Vasc Biol 20 2000 1116 1122
7. J.L. Mehta, D. Li, H. Chen, J. Joseph, and F. Romeo Inhibition of LOX-1 by statins may relate to upregulation of eNOS Biochem Biophys Res Commun 289 2001 857 861
8. D. Li, L. Liu, H. Chen, T. Sawamura, and J.L. Mehta LOX-1 mediates oxidized LDL-induced the expression and activation of matrix metalloproteinases (MMPs) in human coronary artery endothelial cells Circulation 107 2003 612 617
9. D. Li, L. Liu, H. Chen, T. Sawamura, and J.L. Mehta LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells Arterioscler Thromb Vasc Biol 23 2003 816 821
10. N. Kume, H. Arai, C. Kawai, and T. Kita Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoprotein Biochim Biophys Acta 1091 1991 63 67
11. T. Sawamura, N. Kume, T. Aoyama, H. Moriwaki, H. Hoshikawa, and Y. Ariba An endothelial receptor for oxidized low-density lipoprotein Nature 886 1997 73 77
12. S. Ren, S. Shatadal, and G.X. Shen Protein kinase C-beta mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells Am J Physiol 278 2000 E656 E662
13. T. Kita, Y. Nagano, M. Yokode, K. Ishii, N. Kume, and A. Ooshima Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia Proc Natl Acad Sci U S A 84 1987 5928 5931
14. C.M. Yang, C.S. Chien, L.D. Hsiao, S.L. Pan, C.C. Wang, and C.T. Chiu Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway Br J Pharmacol 132 2001 1531 1541
15. S. Ehara, M. Ueda, T. Naruko, K. Haze, A. Itoh, and M. Otsuka Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes Circulation 103 2001 1930 1932
16. S. Ehara, M. Ueda, T. Naruko, K. Haze, T. Matsuo, and M. Ogami Pathophysiological role of oxidized low-density lipoprotein in plaque instability in coronary artery diseases J Diabetes Complications 16 2002 60 64
17. K. Hayashida, N. Kume, T. Murase, M. Minami, D. Nakagawa, and T. Inada Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosis Circulation 112 2005 812 818