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Volumn 11, Issue 5, 2009, Pages 1171-1174

Sc(OTf)3-catalyzed direct alkylation of quinolines and pyridines with alkanes

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EID: 64349088291     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol900070x     Document Type: Article
Times cited : (154)

References (68)
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    • For recent successful examples of direct functionalization of pyridines and quinolines, see: a
    • For recent successful examples of direct functionalization of pyridines and quinolines, see: (a) Lewis, J. C.; Bergman, R. G.; Ellman, J. A. J. Am. Chem. Soc. 2007, 129, 5332.
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    • For recent examples of direct functionalization of pyridine N-oxide and N-iminopyridinum ylide, see: (a) Campeau, L. C.; Rousseaux, S.; Fagnou, K. J. Am. Chem. Soc. 2005, 127, 18020.
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    • Tetrahydroisoquinoline also reacted with cyclooctane and gave 4b in 64% yield when 3 equiv of tert-butyl peroxide was used.
    • Tetrahydroisoquinoline also reacted with cyclooctane and gave 4b in 64% yield when 3 equiv of tert-butyl peroxide was used.
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    • In all cases, no alkylation of pyridine and quinoline derivatives at the meta-position of nitrogen was observed. For quinoline, a trace amount of monoalkylation product was observed with alkylation occurring at the ortho position of nitrogen
    • In all cases, no alkylation of pyridine and quinoline derivatives at the meta-position of nitrogen was observed. For quinoline, a trace amount of monoalkylation product was observed with alkylation occurring at the ortho position of nitrogen.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.