GAR22: A novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells

Experimental Hematology

Volumn 37, Issue 5, 2009, Pages

  Gamper, Ivonne ^a,b   Koh, Ki Ryang ^a   Ruau, David ^a,b   Ullrich, Katrin ^a,b   Bartunkova, Jana ^c   Piroth, Daniela ^d   Hacker, Christine ^a   Bartunek, Petr ^c   Zenke, Martin ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; KRUPPEL LIKE FACTOR 9; STEM CELL FACTOR; THYROID HORMONE; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; DNA MICROARRAY; ERYTHROID CELL; GARR22 GENE; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

CELL CYCLE; CELL DIFFERENTIATION; CELLS, CULTURED; ERYTHROID PRECURSOR CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIGANDS; MICROFILAMENT PROTEINS; RECEPTORS, THYROID HORMONE; TRIIODOTHYRONINE; TUMOR SUPPRESSOR PROTEINS;

EID: 64249171795     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2009.02.002     Document Type: Article

References (52)

1. Orkin S.H., and Zon L.I. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132 (2008) 631-644
2. Cantor A.B., and Orkin S.H. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21 (2002) 3368-3376
3. Wessely O., Deiner E.-M., Beug H., and von Lindern M. The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J 16 (1997) 267-280
4. Bartunek P., and Zenke M. Retinoid X receptor and c-cerbA/thyroid hormone receptor regulate erythroid cell growth and differentiation. Mol Endocrinol 12 (1998) 1269-1279
5. Bauer A., Tronche F., Wessely O., et al. The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev 13 (1999) 2996-3002
6. Leberbauer C., Boulme F., Unfried G., Huber J., Beug H., and Müllner E.W. Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors. Blood 105 (2005) 85-94
7. Tanabe O., McPhee D., Kobayashi S., et al. Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J 26 (2007) 2295-2306
8. Fein H.G., and Rivlin R.S. Anemia in thyroid diseases. Med Clin North Am 59 (1975) 1133-1145
9. Beamer W.J., Eicher E.M., Maltais L.J., and Southard J.L. Inherited primary hypothyroidism in mice. Science 212 (1981) 61-63
10. Beug H., Mullner E.W., and Hayman M.J. Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus. Curr Opin Cell Biol 6 (1994) 816-824
11. Zenke M., Kahn P., Disela C., et al. v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (band 3) gene. Cell 52 (1988) 107-119
12. Zenke M., Munoz A., Sap J., Vennström B., and Beug H. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell 61 (1990) 1035-1049
13. Disela C., Glineur C., Bugge T., et al. v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII. Genes Dev 5 (1991) 2033-2047
14. Schroeder C., Gibson L., and Beug H. The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor. Oncogene 7 (1992) 203-216
15. Forrest D., and Vennström B. Functions of thyroid hormone receptors in mice. Thyroid 10 (2000) 41-52
16. O'Shea P.J., and Williams G.R. Insight into the physiological actions of thyroid hormone receptors from genetically modified mice. J Endocrinol 175 (2002) 553-570
17. Flamant F., and Samarut J. Thyroid hormone receptors: lessons from knockout and knock-in mutant mice. Trends Endocrinol Metab 14 (2003) 85-90
18. Bauer A., Mikulits W., Lagger G., Stengl G., Brosch G., and Beug H. The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors. EMBO J 17 (1998) 4291-4303
19. Zhang J., and Lazar M.A. The mechanism of action of thyroid hormones. Annu Rev Physiol 62 (2000) 439-466
20. Flamant F., Gauthier K., and Samarut J. Thyroid hormones signaling is getting more complex: STORMs are coming. Mol Endocrinol 21 (2007) 321-333
21. Lazar M.A. Thyroid hormone action: a binding contract. J Clin Invest 112 (2003) 497-499
22. Panzenböck B., Bartunek P., Mapara M.Y., and Zenke M. Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro. Blood 92 (1998) 3658-3668
23. von Lindern M., Zauner W., Mellitzer G., et al. The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood 94 (1999) 550-559
24. Dolznig H., Boulme F., Stangl K., et al. Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays. FASEB J 15 (2001) 1442-1444
25. Zhang D., Johnson M.M., Miller C.P., Pircher T.J., Geiger J.N., and Wojchowski D.M. An optimized system for studies of EPO-dependent murine pro-erythroblast development. Exp Hematol 29 (2001) 1278-1288
26. Samuels H.H., Stanley F., and Casanova J. Depletion of L-3,5,3'-triiodothyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone. Endocrinology 105 (1979) 80-85
27. Beug H., Steinlein P., Bartunek P., and Hayman M.J. Avian hematopoietic cell culture: in vitro model systems to study oncogenic transformation of hematopoietic cells. Methods Enzymol 254 (1995) 41-76
28. Southcott M.J., Tanner M.J., and Anstee D.J. The expression of human blood group antigens during erythropoiesis in a cell culture system. Blood 93 (1999) 4425-4435
29. Schmid I., Cole S.W., Zack J.A., and Giorgi J.V. Measurement of lymphocyte subset proliferation by three-color immunofluorescence and DNA flow cytometry. J Immunol Methods 235 (2000) 121-131
30. Bartunek P., Pichlikova L., Stengl G., et al. Avian stem cell factor (SCF): production and characterization of the recombinant His-tagged SCF of chicken and its neutralizing antibody. Cytokine 8 (1996) 14-20
31. Lennon G., Auffray C., Polymeropoulos M., and Soares M.B. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 33 (1996) 151-152
32. Petkovich M., Brand N.J., Krust A., and Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330 (1987) 444-450
33. Mangelsdorf D.J., Ong E.S., Dyck J.A., and Evans R.M. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345 (1990) 224-229
34. Trainor C.D., Evans T., Felsenfeld G., and Boguski M.S. Structure and evolution of a human erythroid transcription factor. Nature 343 (1990) 92-96
35. Yarden Y., Kuang W.J., Yang-Feng T., et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6 (1987) 3341-3351
36. Hacker C., Kirsch R.D., Ju X.S., et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 4 (2003) 380-386
37. Hieronymus T., Gust T.C., Kirsch R.D., et al. Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro. J Immunol 174 (2005) 2552-2562
38. Ihaka R., and Gentleman R. R: a language for data analysis and graphics. J Comput Graph Stat 5 (1996) 299-314
39. Pear W.S., Nolan G.P., Scott M.L., and Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A 90 (1993) 8392-8396
40. Landazuri N., Gupta M., and Le Doux J.M. Rapid concentration and purification of retrovirus by flocculation with Polybrene. J Biotechnol 125 (2006) 529-539
41. Haydar T.F., Wang F., Schwartz M.L., and Rakic P. Differential modulation of proliferation in the neocortical ventricular and subventricular zones. J Neurosci 20 (2000) 5764-5774
42. Nowakowski R.S., Lewin S.B., and Miller M.W. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J Neurocytol 18 (1989) 311-318
43. Denver R.J., Ouellet L., Furling D., Kobayashi A., Fujii-Kuriyama Y., and Puymirat J. Basic transcription element-binding protein (BTEB) is a thyroid hormone-regulated gene in the developing central nervous system. Evidence for a role in neurite outgrowth. J Biol Chem 274 (1999) 23128-23134
44. Leonard M., Brice M., Engel J.D., and Papayannopoulou T. Dynamics of GATA transcription factor expression during erythroid differentiation. Blood 82 (1993) 1071-1079
45. De Maria R., Zeuner A., Eramo A., et al. Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature 401 (1999) 489-493
46. Ribeil J.A., Zermati Y., Vandekerckhove J., et al. Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445 (2007) 102-105
47. Rylski M., Welch J.J., Chen Y.Y., et al. GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol 23 (2003) 5031-5042
48. Zucman-Rossi J., Legoix P., and Thomas G. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. Genomics 38 (1996) 247-254
49. Schneider C., King R.M., and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 54 (1988) 787-793
50. Goriounov D., Leung C.L., and Liem R.K. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. J Cell Sci 116 (2003) 1045-1058
51. Angelin-Duclos C., Domenget C., Kolbus A., Beug H., Jurdic P., and Samarut J. Thyroid hormone T3 acting through the thyroid hormone alpha receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse. Development 132 (2005) 925-934
52. Kendrick T.S., Payne C.J., Epis M.R., et al. Erythroid defects in TRalpha -/- mice. Blood 111 (2008) 3245-3248