Toxicity of ethacrynic acid in isolated rat hepatocytes

Toxicology in Vitro

Volumn 16, Issue 2, 2002, Pages 151-158

  Yamamoto, K ^a   Masubuchi, Y ^a   Narimatsu, S ^a   Kobayashi, S ^b   Horie, T ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Ethacrynic acid; Glutathione; Hepatotoxicity; Lipid peroxidation; Protein sulfhydryl

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CELL PROTEIN; ETACRYNIC ACID; GLUTATHIONE; LIPID; LOOP DIURETIC AGENT; N,N' DIPHENYL 1,4 PHENYLENEDIAMINE; PROADIFEN; PROMETHAZINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL ASSAY; CELL ISOLATION; CELL LEVEL; CELL SUSPENSION; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOTOXICITY; ENZYME ANALYSIS; LIPID PEROXIDATION; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PROTEIN CONTENT; RAT;

ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIURETICS; DRUG ANTAGONISM; ETHACRYNIC ACID; HEPATOCYTES; LIPID PEROXIDATION; MALE; PHENYLENEDIAMINES; PROADIFEN; PROMETHAZINE; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0036181625     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(01)00107-2     Document Type: Article

References (28)

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3. Microsomal lipid peroxidation
4. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells
5. Hepatocellular damage with ethacrynic acid
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7. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P450 IIE1)
8. Tissue sulfhydryl groups
9. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes
10. Determination of cysteine and glutathione in plasma and blood by liquid chromatography with electrochemical detection using a chemically modified electrode containing cobalt phthalocyanine
11. Inhibition of glutathione-related enzymes and cytotoxicity of ethacrynic acid and cyclosporine
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13. Picomole analysis of glutathione, glutathione disulfide, glutathione S-sulfonate and cysteine S-sulfonate by high-performance liquid chromatography
14. Metabolism and biliary excretion of ethacrynic acid
15. Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents
16. Status of the mitochondrial pool of glutathione in the isolated hepatocyte
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18. Fish oil, alcohol, and liver pathology: Role of cytochrome P450 2E1
19. Vitamin E protection against chemical-induced cell injury
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