Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2655-2666

  López Cara, Luisa C ^a   Camacho, M Encarnación ^a   Carrión, M Dora ^a   Tapias, Víctor ^b   Gallo, Miguel A ^a   Escames, Germaine ^b   Acuña Castroviejo, Darío ^b   Espinosa, Antonio ^a   Entrena, Antonio ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Inducible NOS; Inhibitors; Mitochondrial NOS; Neural NOS; Phenylpyrrole derivatives

Indexed keywords

5 (2 AMINO 5 CHLOROPHENYL) 1H PYRROLE 2 CARBOXAMIDE; 5 (2 AMINO 5 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID BUTYLAMIDE; 5 (2 AMINO 5 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOPROPYLAMIDE; 5 (2 AMINO 5 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYLAMIDE; 5 (2 AMINO 5 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID METHYLAMIDE; 5 (2 AMINO 5 METHOXYPHENYL) 1H PYRROLE 2 CARBOXAMIDE; 5 (2 AMINO 5 METHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID BENZYLAMIDE; 5 (2 AMINO 5 METHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOPENTYLAMIDE; 5 (2 AMINO 5 METHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOPROPYLAMIDE; 5 (2 AMINO 5 METHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID METHYLAMIDE; 5 (2 AMINO 5 METHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID PROPYLAMIDE; 5 (2 AMINOPHENYL) 1 METHYL 1H PYRROLE 2 CARBOXAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID BENZYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID BUTYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOBUTYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOPENTYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID CYCLOPROPYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID METHYLAMIDE; 5 (2 AMINOPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID PROPYLAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLPYRROLE DERIVATIVE; QFF 193; QFF 194; QFF 195; QFF 196; QFF 197; QFF 198; QFF 199; QFF 200; QFF 201; QFF 202; QFF 203; QFF 204; QFF 205; QFF 206; QFF 207; QFF 208; QFF 209; QFF 210; QFF 211; QFF 212; QFF 213; QFF 214; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; RAT;

ANIMALS; BINDING SITES; CYTOSOL; DRUG DESIGN; ENZYME INHIBITORS; MICE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; PYRAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64249162692     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.11.013     Document Type: Article

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