Studies on chemical structure modification and biology of a natural product, Gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2611-2620

  Wang, Jinxin ^a   Zhao, Li ^a   Hu, Yang ^a   Guo, Qinglong ^a   Zhang, Lei ^a   Wang, Xiaojian ^a   Li, Nianguang ^a   You, Qidong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti tumor; Apoptosis inducer; Gambogic acid derivatives; Structure activity relationship

Indexed keywords

(32,33), (37,38) DI EPOXYL 6 METHOXYLGAMBOGIC ACID METHYLESTER; (32,33), (37,38) DI EPOXYLGAMBOGIC ACID; (34,39) DIHYDROXY GAMBOGIC ACID; (37,38)EPOXY 6 METHOXYLGAMBOGIC ACID METHYLESTER; (9,10) DIHYDROXY GAMBOGIC ACID; 34 HYDROXY 39 FORMYLGAMBOGIC ACID; 34 HYDROXY GAMBOGIC ACID; 39 HYDROXY 6 METHOXY GAMBOGIC ACID METHYLESTER; 40 ACETOXY 6 METHOXY GAMBOGIC ACID METHYLESTER; DIHYDROXY 6 METHOXY GAMBOGIC ACID METHYLESTER; GAMBOGIC ACID; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; BIOLOGICAL FACTORS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

EID: 64249157689     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.034     Document Type: Article

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