Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes

Acta Pharmacologica Sinica

Volumn 27, Issue 9, 2006, Pages 1253-1258

  Liu, Yi Tong ^a   Hao, Kun ^a   Liu, Xiao Quan ^a   Wang, Guang Ji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cytochrome P 450; Gambogic acid; Liver microsomes; Metabolic inhibition; Metabolism

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; EPOXIDE; GAMBOGIC ACID; KETOCONAZOLE; QUINIDINE; SULFAPHENAZOLE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ELIMINATION; DRUG METABOLISM; ENZYME INHIBITION; ENZYME KINETICS; HYDRATION; LIVER MICROSOME; NONHUMAN; RAT;

ANIMALS; BENZOFLAVONES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; KETOCONAZOLE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SULFAPHENAZOLE; XANTHONES;

EID: 33748799712     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00369.x     Document Type: Article

References (11)

1. Zhang HZ, Kasibhatla S, Wang Y, Herich J, Guastella J, Tseng B, et al. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg Med Chem 2004; 12: 309-17.
2. Liu W, Guo QL, Li Z, Gu HY. Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823. World J Gastroenterol 2005; 11: 3655-9.
3. Guo QL, You QD, Wu ZQ, Yuan ST, Zhao L. General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. Acta Pharmacol Sin 2004; 25: 769-74.
4. Wu ZQ, Guo QL, You QD, Zhao L, Gu HY. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol Pharm Bull 2004; 27: 1769-74.
5. Zhao L, Guo QL, You QD, Wu ZQ, Gu HY. Gambogic acid induces apoptosis and regulates expression of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol Pharm Bull 2004; 27: 998-1003.
6. Kasibnatla S, Jessen KA, Maliartchouk S, Wang JY, English NM, Drewe J, et al. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Cell Biol 2005; 102: 12095-100.
7. Liu XQ, Zhao Y, Li D, Qian ZY, Wang GJ. Metabolism and metabolic inhibition of clinipine in human liver microsomes. Acta Pharmacol Sin 2003; 24: 263-8.
8. Dawson JM, Heatlie PL. Lowry method of protein quantification: evidence for photosensitivity. Anal Biochem 1984; 140: 391-3.
9. Hao K, Liu XQ, Wang GJ. Pharmacokinetics of gambogic Acid in rats. J China Pharm Univ 2005; 36: 338-41. Chinese
10. Nakajima M, Inoue T, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y. Cytochrome P4502C9 catalyzes indomethacin O-demethylation in human liver microsomes. Drug Metab Dispos 1998; 26: 261-6.
11. Bjornsson T, Callaghan J, Einolf H, Fischer V, Gan L, Grimm S, et al. The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective. Drug Metab Dispos 2003; 31: 815-32.