Unique Characteristics of Fungal Infections in Lung Transplant Recipients

Clinics in Chest Medicine

Volumn 30, Issue 2, 2009, Pages 307-313

  Husain, Shahid ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Aspergillus; Candida; Fungal; Lung transplant; Prophylaxis

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; FLUCONAZOLE; GALACTOMANNAN; ITRACONAZOLE; VORICONAZOLE;

ASPERGILLOSIS; ASPERGILLUS; CANDIDA; CANDIDIASIS; CLINICAL FEATURE; COUGHING; CRYPTOCOCCOSIS; CRYPTOCOCCUS; DRUG WITHDRAWAL; DYSPNEA; FUNGAL COLONIZATION; GRAFT RECIPIENT; HUMAN; INCIDENCE; INFECTION RISK; INFECTION SENSITIVITY; LUNG TRANSPLANTATION; MYCOSIS; NAUSEA; PNEUMONIA; PRIORITY JOURNAL; REVIEW; TRACHEOBRONCHITIS; WHEEZING;

HUMANS; LUNG TRANSPLANTATION; MYCOSES;

EID: 64249100986     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2009.03.002     Document Type: Review

References (44)

1. National Data on Lung transplant, 2009.
2. Christie J.D., Edwards L.B., Aurora P., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart/lung transplantation report-2008. J Heart Lung Transplant 27 (2008) 957-969
3. Trulock E.P., Edwards L.B., Taylor D.O., et al. The registry of the International Society for Heart and Lung Transplantation: twenty-first official adult heart transplant report-2004. J Heart Lung Transplant 23 (2004) 804-815
4. Kubak B.M. Fungal infection in lung transplantation. Transpl Infect Dis 4 Suppl 3 (2002) 24-31
5. Silveira F.P., and Husain S. Fungal infections in lung transplant recipients. Curr Opin Pulm Med 14 (2008) 211-218
6. Chan KM. Approach towards infectious pulmonary complications in lung transplant recipients. In: Singh N, Aguado JM, editors. Infectious complications in transplant patients. Semin Respir Infect 2002;17(4): 291-302.
7. Yeldandi V., Laghi F., McCabe M.A., et al. Aspergillus and lung transplantation. J Heart Lung Transplant 14 (1995) 883-890
8. Kanj S.S., Tapson V., Davis R.D., et al. Infections in patients with cystic fibrosis following lung transplantation. Chest 112 (1997) 924-930
9. Westney G.E., Kesten S., De Hoyos A., et al. Aspergillus infection in single and double lung transplant recipients. Transplantation 61 (1996) 915-919
10. Morgan J., Wannemuehler K.A., Marr K.A., et al. Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program. Med Mycol 43 Suppl 1 (2005) S49-S58
11. Husain S. Differences in invasive aspergillosis in solid organ transplant recipients, 2008. Available at: http://www.aspergillus.org.uk/indexhome.htm?secure/conferences/confabstracts/inputform.php∼main. Accessed January 10, 2009.
12. Higgins R., McNeil K., Dennis C., et al. Airway stenoses after lung transplantation: management with expanding metal stents. J Heart Lung Transplant 13 (1994) 774-778
13. Singh N., and Husain S. Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management. J Heart Lung Transplant 22 (2003) 258-266
14. Goldfarb N.S., Avery R.K., Goormastic M., et al. Hypogammaglobulinemia in lung transplant recipients. Transplantation 71 (2001) 242-246
15. Crespo M, Raza K, Studer S, et al. Risk of pulmonary aspergillosis after bronchial stent placement in lung transplant (LTx) recipients. Presented at the 26th Annual Meeting and Scientific Sessions of the International Society of Heart and Lung Transplantation. Madrid, Spain, April 5-6, 2006.
16. Danziger-Isakov L.A., Worley S., Arrigain S., et al. Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant 27 (2008) 655-661
17. Palmer S.M., Alexander B.D., Sanders L.L., et al. Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplantation 69 (2000) 2360-2366
18. Husain S., Wagener M.M., and Singh N. Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome. Emerg Infect Dis 7 (2001) 375-381
19. Vilchez R., Shapiro R., McCurry K.R., et al. Longitudinal study of cryptococcosis in adult solid-organ transplant recipients. Transpl Int 16 5 (2003) 336-340
20. Helmi M., Love R.B., Welter D., et al. Aspergillus infection in lung transplant recipients with cystic fibrosis: risk factors and outcomes comparison to other types of transplant recipients. Chest 123 (2003) 800-808
21. Nunley D.R., Ohori P., Grgurich W.F., et al. Pulmonary aspergillosis in cystic fibrosis lung transplant recipients. Chest 114 (1998) 1321-1329
22. Husain S., Paterson D.L., Studer S., et al. Voriconazole prophylaxis in lung transplant recipients. Am J Transplant 6 (2006) 3008-3016
23. Chaparro C., and Kesten S. Infections in lung transplant recipients. Clin Chest Med 18 (1997) 339-351
24. Silveira F.P., Kwak E.J., Paterson D.L., et al. Post-transplant colonization with non-Aspergillus molds and risk of development of invasive fungal disease in lung transplant recipients. J Heart Lung Transplant 27 (2008) 850-855
25. Sole A., Morant P., Salavert M., et al. Aspergillus infections in lung transplant recipients: risk factors and outcome. Clin Microbiol Infect 11 (2005) 359-365
26. Kramer M.R., Denning D.W., Marshall S.E., et al. Ulcerative tracheobronchitis after lung transplantation. A new form of invasive aspergillosis. Am Rev Respir Dis 144 (1991) 552-556
27. Hadjiliadis D., Howell D.N., Davis R.D., et al. Anastomotic infections in lung transplant recipients. Ann Transplant 5 (2000) 13-19
28. Palmer S.M., Perfect J.R., Howell D.N., et al. Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents. J Heart Lung Transplant 17 (1998) 1029-1033
29. Paterson D.L., and Singh N. Invasive aspergillosis in transplant recipients. Medicine (Baltimore) 78 (1999) 123-138
30. Singh N., and Paterson D.L. Aspergillus infections in transplant recipients. Clin Microbiol Rev 18 (2005) 44-69
31. Husain S., Kwak E.J., Obman A., et al. Prospective assessment of Platelia Aspergillus galactomannan antigen for the diagnosis of invasive aspergillosis in lung transplant recipients. Am J Transplant 4 (2004) 796-802
32. Husain S., Paterson D.L., Studer S.M., et al. Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. Transplantation 83 (2007) 1330-1336
33. Husain S., Clancy C.J., Nguyen M.H., et al. Performance characteristics of the Platelia Aspergillus enzyme immunoassay for detection of Aspergillus galactomannan antigen in bronchoalveolar lavage fluid. Clin Vaccine Immunol 15 (2008) 1760-1763
34. Husain S., Zaldonis D., Kusne S., et al. Variation in antifungal prophylaxis strategies in lung transplantation. Transpl Infect Dis 8 4 (2006) 213-218
35. Dummer J.S., Lazariashvilli N., Barnes J., et al. A survey of anti-fungal management in lung transplantation. J Heart Lung Transplant 23 (2004) 1376-1381
36. Reichenspurner H., Gamberg P., Nitschke M., et al. Significant reduction in the number of fungal infections after lung-, heart-lung, and heart transplantation using aerosolized amphotericin B prophylaxis. Transplant Proc 29 (1997) 627-628
37. Monforte V., Roman A., Gavalda J., et al. Nebulized amphotericin B prophylaxis for Aspergillus infection in lung transplantation: study of risk factors. J Heart Lung Transplant 20 (2001) 1274-1281
38. Calvo V., Borro J.M., Morales P., et al. Antifungal prophylaxis during the early postoperative period of lung transplantation. Valencia Lung Transplant Group. Chest 115 (1999) 1301-1304
39. Drew R.H., Dodds A.E., Benjamin Jr. D.K., et al. Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients. Transplantation 77 (2004) 232-237
40. Borro J.M., Sole A., de la T.M., et al. Efficiency and safety of inhaled amphotericin B lipid complex (Abelcet) in the prophylaxis of invasive fungal infections following lung transplantation. Transplant Proc 40 (2008) 3090-3093
41. Monforte V., Roman A., Gavalda J., et al. Nebulized liposomal amphotericin B (n-LAB) prophylaxis for Aspergillus infection in lung transplantation (LT): pharmacokinetics, safety and efficacy. J Heart Lung Transplant 24 Suppl 2 (2005) S108-S109
42. Corcoran T.E., Venkataramanan R., Mihelc K.M., et al. Aerosol deposition of lipid complex amphotericin-B (Abelcet) in lung transplant recipients. Am J Transplant 6 (2006) 2765-2773
43. Monforte V., Roman A., Gavalda J., et al. Nebulized amphotericin B concentration and distribution in the respiratory tract of lung-transplanted patients. Transplantation 75 (2003) 1571-1574
44. Minari A., Husni R., Avery R.K., et al. The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants. Transpl Infect Dis 4 (2002) 195-200