Structure-activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2339-2346

  Santos, Cledir R ^a   Capela, Rita ^b   Pereira, Cláudia S G P ^a   Valente, Emília ^b   Gouveia, Luís ^b   Pannecouque, Christophe ^c   De Clercq, Erik ^c   Moreira, Rui ^b   Gomes, Paula ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclovir; Antiviral; Dipeptide; Drug delivery; Herpes Simplex; Prodrug

Indexed keywords

9 [[2 (O ALANYLVALYL)HYDROXYETHOXY]METHYL]GUANINE TRIFLUOROACETIC ACID SALT; 9 [[2 (O GLYCYLALANYL)HYDROXYETHOXY]METHYL]GUANINE TRIFLUOROACETIC ACID SALT; 9 [[2 (O GLYCYLPHENYLALANYL)HYDROXYETHOXY]METHYL]GUANINE TRIFLUOROACETIC ACID SALT; 9 [[2 (O PHENYLALANYLGLYCYL)HYDROXYETHOXY]METHYL]GUANINE TRIFLUOROACETIC ACID SALT; 9 [[2 (O PHENYLALANYLVALYL)HYDROXYETHOXY]METHYL]GUANINE TRIFLUOROACETIC ACID SALT; ACICLOVIR; CAPTOPRIL; PARACETAMOL; PRIMAQUINE; PRODRUG; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOMEGALOVIRUS; DRUG DESIGN; DRUG EFFECT; DRUG RELEASE; DRUG STABILITY; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; STRUCTURE ACTIVITY RELATION; VACCINIA; VARICELLA ZOSTER VIRUS; VESICULAR STOMATITIS; VIRUS STRAIN;

ACYCLOVIR; ANTIVIRAL AGENTS; CELL LINE; CELL PROLIFERATION; CYTOMEGALOVIRUS; DIPEPTIDES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HERPESVIRUS 3, HUMAN; HUMANS; HYDROLYSIS; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; VACCINIA VIRUS; VESICULOVIRUS;

EID: 64249094656     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.08.009     Document Type: Article

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