Effects of steric bulk and stereochemistry on the rates of diketopiperazine formation from N-aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides)-a model for a new prodrug linker system

Tetrahedron

Volumn 62, Issue 48, 2006, Pages 11245-11266

  Suaifan, Ghadeer A R Y ^a   Mahon, Mary F ^b   Arafat, Tawfiq ^c   Threadgill, Michael D ^a  

^a University of Bath   (United Kingdom)

^b University of Bath Claverton Down   (United Kingdom)

^c UNIVERSITY OF PETRA   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIMETHYL 3 GLYCYL N [2 (4 NITROPHENYL)ETHYL]TETRAHYDROTHIAZOLE 4 CARBOXAMIDE TRIFLUOROACETATE; 2,2 DIMETHYL N [2 (4 NITROPHENYL)ETHYL] 3 (PHENYLALANYL)TETRAHYDROTHIAZOLE 4 CARBOXAMIDE TRIFLUOROACETATE; 2,2 DIMETHYL N [2 (4 NITROPHENYL)ETHYL] 3 (VALINYL)TETRAHYDROTHIAZOLE 4 CARBOXAMIDE TRIFLUOROACETATE; 3 (ALANYL) 2,2 DIMETHYL N [2 (4 NITROPHENYL)ETHYL]TETRAHYDROTHIAZOLE 4 CARBOXAMIDE TRIFLUOROACETATE; 3,3 DIMETHYL 6 (1 METHYLETHYL)TETRAHYDROTHIAZOLO[3,4 A]PYRAZINE 5,8 DIONE; 3,3 DIMETHYL 6 PHENYLMETHYLTETRAHYDROTHIAZOLO[3,4 A]PYRAZINE 5,8 DIONE; 3,3,6 TRIMETHYLTETRAHYDROTHIAZOLO[3,4 A]PYRAZINE 5,8 DIONE; AMIDE; AMINE; AMINO ACID; DIPEPTIDE DERIVATIVE; ETHYLAMINE; PIPERAZINEDIONE; PRODRUG; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CYCLIZATION; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY;

EID: 33750024512     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.09.009     Document Type: Article

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