Mutations in subdomain B of the minichromosome maintenance (MCM) helicase affect DNA binding and modulate conformational transitions

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 5654-5661

  Jenkinson, Elizabeth R ^a,d   Costa, Alessandro ^b,e   Leech, Andrew P ^a   Patwardhan, Ardan ^b   Onesti, Silvia ^b,c   Chong, James P J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c SINCROTRONE TRIESTE   (Italy)

^d GREEN BIOLOGICS LTD   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHAEA; ARGININE RESIDUE; BIOPHYSICAL ANALYSIS; CONFORMATIONAL CHANGE; CONFORMATIONAL TRANSITIONS; DNA BINDING; DODECAMER; DOUBLE MUTANTS; HELICASE; HELICASE ACTIVITIES; HEPTAMER; HEPTAMERIC RINGS; HEXAMERIC RINGS; HIGH MOLECULAR WEIGHT; METHANOTHERMOBACTER THERMAUTOTROPHICUS; MICROSCOPY TECHNIQUE; N-TERMINAL; SUBDOMAIN;

AMINO ACIDS; DNA; ELECTRON MICROSCOPES; ELECTRON MICROSCOPY; GENES; HYDROGEN; HYDROGEN BONDS; MAINTENANCE; NUCLEIC ACIDS;

COMPLEXATION;

MINICHROMOSOME MAINTENANCE PROTEIN; MUTANT PROTEIN; ARCHAEAL DNA; ARCHAEAL PROTEIN; DNA BINDING PROTEIN; HELICASE; MCM PROTEIN, METHANOBACTERIUM THERMOAUTOTROPHICUM;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; EUKARYOTE; GENE MUTATION; HYDROGEN BOND; METHANOBACTERIUM THERMOAUTOTROPHICUM; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DNA BINDING; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; METHANOBACTERIUM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; ULTRACENTRIFUGATION;

EUKARYOTA; METHANOTHERMOBACTER THERMAUTOTROPHICUS;

AMINO ACID SEQUENCE; ARCHAEAL PROTEINS; DNA HELICASES; DNA, ARCHAEAL; DNA-BINDING PROTEINS; METHANOBACTERIACEAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; ULTRACENTRIFUGATION;

EID: 64149103213     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806973200     Document Type: Article

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