B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-γ production but not cytotoxicity

European Journal of Immunology

Volumn 39, Issue 3, 2009, Pages 826-832

  Alcón, Valeria L ^a   Luther, Claudia ^a   Balce, Dale ^a   Takei, Fumio ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cell activation; Cytokines; Cytotoxicity; NK cells; Rodents

Indexed keywords

CD72 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; B LYMPHOCYTE ANTIGEN; CD72 ANTIGEN, MOUSE; INTERLEUKIN 2; LEUKOCYTE ANTIGEN; NATURAL KILLER CELL RECEPTOR; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY TEST; LYMPHOCYTE SUBPOPULATION; MOUSE; MUTATIONAL ANALYSIS; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SYNTHESIS INHIBITION; TARGET CELL; ANIMAL; B LYMPHOCYTE; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CYTOTOXICITY; DRUG EFFECT; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-18; INTERLEUKIN-2; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; RECEPTORS, NATURAL KILLER CELL; RECOMBINANT PROTEINS;

EID: 64049113962     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838682     Document Type: Article

References (22)

1. Bryceson, Y. T., March, M. E., Ljunggren, H. G. and Long, E. O., Activation, coactivation, and costimulation of resting human natural killer cells. Immunol. Rev. 2006. 214: 73-91.
2. Lanier, L. L., NK cell recognition. Annu. Rev. Immunol. 2005. 23: 225-274.
3. Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. and Salazar-Mather, T. P., Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 1999. 17: 189-220.
4. Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C. Y., Ferrante, J., Stewart, C. et al., IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996. 4: 471-481.
5. Okamura, H., Kashiwamura, S., Tsutsui, H., Yoshimoto, T. and Nakanishi, K., Regulation of interferon-gamma production by IL-12 and IL-18. Curr. Opin. Immunol. 1998. 10: 259-264.
6. Walker,W., Aste-Amezaga, M., Kastelein, R. A., Trinchieri, G. and Hunter, C. A., IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma. J. Immunol. 1999. 162: 5894-5901.
7. Bacon, C. M., McVicar, D. W., Ortaldo, J. R., Rees, R. C., O'Shea, J. J. and Johnston, J. A., Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 1995. 181: 399-404.
8. Watford, W. T., Hissong, B. D., Bream, J. H., Kanno, Y., Muul, L. and O'Shea, J. J., Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 2004. 202: 139-156.
9. Wald, D., Commane, M., Stark, G. R. and Li, X., IRAK and TAK1 are required for IL-18-mediated signaling. Eur. J. Immunol. 2001. 31: 3747-3754.
10. Parnes, J. R. and Pan, C., CD72, a negative regulator of B-cell responsiveness. Immunol. Rev. 2000. 176: 75-85.
11. Kumanogoh, A. and Kikutani, H., The CD100-CD72 interaction: A novel mechanism of immune regulation. Trends Immunol. 2001. 22: 670-676.
12. Veinotte, L. L., Greenwood, C. P., Mohammadi, N., Parachoniak, C. A. and Takei, F., Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment. Blood 2006. 107: 2673-2679.
13. Hayakawa, Y. and Smyth, M. J., CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J. Immunol. 2006. 176: 1517-1524.
14. Carson, W. E., Dierksheide, J. E., Jabbour, S., Anghelina, M., Bouchard, P., Ku, G., Yu, H. et al., Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice: Critical role of natural killer cell interferon-gamma production and STAT-mediated signal transduction. Blood 2000. 96: 1465-1473.
15. Kim, S., Iizuka, K., Kang, H. S., Dokun, A., French, A. R., Greco, S. and Yokoyama, W. M., In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 2002. 3: 523-528.
16. Hesslein, D. G., Takaki, R., Hermiston, M. L., Weiss, A. and Lanier, L. L., Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc. Natl. Acad. Sci. USA 2006. 103: 7012-7017.
17. Hanke, T., Takizawa, H., McMahon, C. W., Busch, D. H., Pamer, E. G., Miller, J. D., Altman, J. D. et al., Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 1999. 11: 67-77.
18. Adachi, T., Flaswinkel, H., Yakura, H., Reth, M. and Tsubata, T., The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J. Immunol. 1998. 160: 4662-4665.
19. Wu, Y., Nadler, M. J., Brennan, L. A., Gish, G. D., Timms, J. F., Fusaki, N., Jongstra-Bilen, J. et al., The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1. Curr. Biol. 1998. 8: 1009-1017.
20. Ishida, I.,Kumanogoh,A., Suzuki,K., Akahani, S.,Noda, K. andKikutani, H., Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: Implications for the regulation of immune and inflammatory responses. Int. Immunol. 2003. 15: 1027-1034.
21. Mizrahi, S., Markel, G., Porgador, A., Bushkin, Y. and Mandelboim, O., CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. PLoS ONE 2007. 2: E818.
22. Veinotte, L. L., Halim, T. Y. and Takei, F., Unique subset of natural killer cells develops from progenitors in lymph node. Blood 2008. 111: 4201-4208.