Blood flow magnetic resonance imaging of retinal degeneration

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 4, 2009, Pages 1824-1830

  Li, Yingxia ^a   Cheng, Haiying ^a   Shen, Qiang ^a,b,c   Kim, Moon ^d   Thule, Peter M ^d,e   Olson, Darin E ^d,e   Pardue, Machelle T ^a,d   Duong, Timothy Q ^a,b,c,d  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

^d ATLANTA VA MEDICAL CENTER   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; NITROGEN; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HYPERCAPNIA; HYPEROXIA; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RETINA BLOOD FLOW; RETINA DEGENERATION; VASOCONSTRICTION; VASODILATATION; VISUAL SYSTEM PARAMETERS; ANIMAL; BLOOD FLOW; GENETICS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT STRAIN; RETINA BLOOD VESSEL;

ANIMALS; HYPERCAPNIA; HYPEROXIA; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, MUTANT STRAINS; REGIONAL BLOOD FLOW; RETINAL DEGENERATION; RETINAL VESSELS;

EID: 64049107907     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2188     Document Type: Article

References (71)

1. Berson EL. Retinitis pigmentosa. The Friedenwald lecture. Invest Ophthalmol Vis Sci. 1993;34:1659-1676.
2. Bourne MC, Campbell DA, Pyke M. Hereditary degeneration of the rat retina. Brit J Ophthalmol. 1938;22:613-623.
3. D'Cruz PM, Yasumura D, Weir J, et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet. 2000;9:645-651.
4. Ball S, Hanzlicek B, Blum M, Pardue MT. Evaluation of inner retinal structure in the aged RCS rat. Adv Exp Med Biol. 2003;533:181-188.
5. LaVail MM. Photoreceptor characteristics in congenic strains of RCS rats. Invest Ophthalmol Vis Sci. 1981;20:671-675.
6. LaVail MM, Battelle BA. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp Eye Res. 1975;21:167-192.
7. Yu D-Y, Cringle SJ, Su E-N, Yu PK. Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat. Invest Ophthalmol Vis Sci. 2000;41:3999-4006.
8. Sieving PA, Caruso RC, Tao W, et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci USA. 2006;103:3896-3901.
9. Acland GM, Aguirre GD, Ray J, Zhang Q, et al. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet. 2001;28:92-95.
10. Rizzo JF 3rd, Wyatt J, Humayun M, et al. Retinal prosthesis: an encouraging first decade with major challenges ahead. Ophthalmology. 2001;108:13-14.
11. Fujimoto JG, Brezinski ME, Tearney GJ, et al. Optical biopsy and imaging using optical coherence tomography. Nat Med. 1995;1: 970-972.
12. Fujimoto JG, Pitris C, Boppart SA, Brezinski ME. Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia. 2000;2:9-25.
13. Shonat RD, Richmond KN, Johnson PC. Phosphorescence quenching and the microcirculation: An automated, multipoint oxygen tension measuring instrument. Rev Sci Instrum. 1995;66:5075-5084.
14. Grinvald A, Bonhoeffer T, Vanzetta I, et al. High-resolution functional optical imaging: from the neocortex to the eye. Ophthalmol Clin North Am. 2004;17:53-67.
15. Zarella MD, Li H, Kwon Y, et al. The origins and spatio-temporal properties of stimulus dependent intrinsic optical signals of the retina. In: Proceedings of the Society for Neuroscience; Oct. 23-27,2004; San Diego, CA. Program 934.910.
16. Zhao YB, Yao XC. Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina. Opt Lett. 2008;33: 342-344.
17. Preussner PR, Richard G, Darrelmann O, et al. Quantitative measurement of retinal blood flow in human beings by application of digital image-processing methods to television fluorescein angiograms. Graefes Arch Clin Exp Ophthalmol. 1983;221:110-112.
18. Guyer DR, Yannuzzi LA, Slakter JS, et al. The status of indocyaninegreen videoangiography. Cur Opin Ophthalmol. 1993;4:3-6.
19. Wajer SD, Taomoto M, McLeod DS, et al. Velocity measurements of normal and sickle red blood cells in the rat retinal and choroidal vasculatures. Microvasc Res. 2000;60:281-293.
20. Cheng H, Duong TQ. Simplified laser-speckle-imaging analysis method and its application to retinal blood flow imaging. Opt Lett. 2007;32:2188-2190.
21. Cheng H, Yan Y, Duong TQ. Temporal statistical analysis of laser speckle image and its application to retinal blood flow imaging. Optics Express. 2008;16:10214-10219.
22. Chauhan BC, Yu PK, Cringle SJ, Yu DY. Confocal scanning laser Doppler flowmetry in the rat retina: origin of flow signals and dependence on scan depth. Arch Ophthalmol. 2006;124:397-402.
23. Slakter JS, Yannuzzi LA, Guyer DR, et al. Indocyanine-green an-giography. Curr Opin Ophthalmol. 1995;6:25-32.
24. Lorentz K, Zayas-Santiago A, Tummala S, Kang Derwent JJ. Scanning laser ophthalmoscope-particle tracking method to assess blood velocity during hypoxia and hyperoxia. Adv Exp Med Biol. 2008;614:253-261.
25. Shen Q, Cheng H, Chang TF, et al. Magnetic resonance imaging of anatomical and vascular layers of the cat retina. J Magn Reson Imaging. 2006;23:465-472.
26. Cheng H, Nair G, Walker TA, et al. Structural and functional MRI reveals multiple retinal layers. Proc Natl Acad Sci USA. 2006;103: 17525-17530.
27. Duong TQ, Pardue MT, Thule PM, et al. Layer-specific anatomical, physiological and functional MRI of the retina. NMR Biomed. 2008;21:978-996.
28. Duong TQ, Ngan S-C, Ugurbil K, Kim S-G. Functional magnetic resonance imaging of the retina. Invest Ophthalmol Vis Sci. 2002; 43:1176-1181.
29. Calamante F, Gadian DG, Connelly A. Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical use. Stroke. 2002;33:1146-1151.
30. Detre JA, Leigh JS, Williams DS, Koretsky AP. Perfusion imaging. Magn Reson Med. 1992;23:37-45.
31. Shen Q, Ren H, Cheng H, et al. Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow and Metab. 2005;25:1265-1279.
32. Muir ER, Shen Q, Duong TQ. Cerebral blood flow MRI in mice using the cardiac-spin-labeling technique. Magn Reson Med. 2008; 60:744-748.
33. Sicard KM, Duong TQ. Effects of hypoxia, hyperoxia and hyper-capnia on baseline and stimulus-evoked BOLD, CBF and CMRO2 in spontaneously breathing animals. Neuroimage. 2005;25:850-858.
34. Duong TQ, Kim DS, Ugurbil K, Kim SG. Localized cerebral blood flow response at submillimeter columnar resolution. Proc Natl Acad Sci USA. 2001;98:10904-10909.
35. Grafton ST. PET: activation of cerebral blood flow and glucose metabolism. Adv Neurol. 2000;83:87-103.
36. Wolf RL, Detre JA. Clinical neuroimaging using arterial spin-labeled perfusion magnetic resonance imaging. Neurotherapeutics. 2007; 4:346-359.
37. Silverman DH, Alavi A. PET imaging in the assessment of normal and impaired cognitive function. Radiol Clin North Am. 2005;43: 67-77.
38. Duong TQ, Silva AC, Lee SP, Kim SG. Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements. Magn Reson Med. 2000;43:383-392.
39. Dowling JE, Sidman RL. Inherited retinal dystrophy in the rat. J Cell Bio. 1962;14:73-109.
40. Sicard K, Shen Q, Brevard ME, et al. Regional cerebral blood flow and BOLD responses in conscious and anesthetized rats under basal and hypercapnic conditions: implications for functional MRI studies. J Cereb Blood Flow Metab. 2003;23:472-481.
41. Duong TQ, Iadecola C, Kim SG. Effect of hyperoxia, hypercapnia, and hypoxia on cerebral interstitial oxygen tension and cerebral blood flow. Magn Reson Med. 2001;45:61-70.
42. Shen Q, Meng X, Fisher M, et al. Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging. J Cereb Blood Flow and Metab. 2003;23: 1479-1488.
43. Herscovitch P, Raichle ME. What is the correct value for the brain-blood partition coefficient for water? J Cereb Blood Flow Metab. 1985;5:65-69.
44. Barbier EL, Liu L, Grillon E, et al. Focal brain ischemia in rat: acute changes in brain tissue T1 reflect acute increase in brain tissue water content. NMR Biomed. 2005;18:499-506.
45. Liu ZM, Schmidt KF, Sicard KM, Duong TQ. Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia. Magn Reson Med. 2004;52:277-285.
46. Li Y, Cheng H, Duong TQ. Blood flow magnetic resonance imaging of the retina. Neuroimage. 2008;39:1744-1751.
47. Alm A, Bill A. Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues. Exp Eye Res. 1973;15:15-29.
48. Wang L, Fortune B, Cull G, et al. Microspheres method for ocular blood flow measurement in rats: size and dose optimization. Exp Eye Res. 2007;84:108-117.
49. Linsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci. 2000;41:3117-3123.
50. Parver LM. Choroidal blood flow as a heat dissipating mechanism in the macula. Am J Ophthalmol. 1980;89:641-646.
51. Parver LM, Auker CR, Carpenter DO, Doyle T. Choroidal blood flow. Arch Ophthalmol. 1982;100:1327-1330.
52. Sternn K, Manapace R, Rainer G, et al. Reproducibility and sensitivity of scanning laser Doppler flowmetry using graded changes in PO2. Br J Ophthalmol. 1997;81:360-364.
53. Fallon TJ, Maxwell DL, Kohner EM. Retinal vascular autoregulation in conditions of hyperoxia and hypoxia using the blue field entopic phenomenon. Ophthalmology. 1985;92:701-705.
54. Riva CE, Grunwald JE, Petrig BL. Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry. Invest Ophthalmol Vis Sci. 1986;27:1706-1712.
55. Riva CE, Grunwald JE, Sinclair SH. Laser Doppler velocimetry study of the effect of pure oxygen breathing on retinal blood flow. Invest Ophthalmol Vis Sci. 1983;24:47-51.
56. Trokel S. Effect of respiratory gases upon choroidal hemodynamics. Arch Ophthalmol. 1965;73:838-842.
57. Riva CE, Cranstoun SD, Grunwald JE, Petrig BL. Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci. 1994;35:4273-4281.
58. Schmetterer L, Wolzt M, Lexer F. The effect of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region in healthy young me. Exp Eye Res. 1995;61:685-690.
59. Schmetterer L, Lexer F, Findl O, et al. The effect of inhalation of different mixtures of O2 and CO2 on ocular fundus pulsation. Exp Eye Res. 1996;63:351-355.
60. Kety SS, Schmidt CF. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest. 1948; 27:484-491.
61. Alm A, Bill A. The oxygen supply to the retina, II: effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. Acta Physiologica Scand. 1972;84:306-319.
62. Alm A, Bill A. The oxygen supply to the retina, I: effects of changes in intraocular and arterial blood pressures, and in arterial pO2 and pCO2 on the oxygen tension in the vitreous body of the cat. Acta Physiol Scand. 1972;84:261-274.
63. Friedman E, Chandra SR. Choroidal blood flow, III: effects of oxygen and carbon dioxide. Arch Ophthalmol. 1972;87:70-71.
64. Cioffi GA, Granstam E, Alm A. Ocular circulation, In: Kaufman PL, Alm A, eds. Adler's Physiology of the Eye: Clinical Application. St. Louis: Mosby 2003;747-784.
65. Frayser R, Hickam JB. Retinal vascular response to breathing increased carbon dioxide and oxygen concentrations. Invest Ophthalmol Vis Sci. 1964;3:427-431.
66. Geiser MH, Riva CE, Dorner GT, et al. Response of choroidal blood flow in the foveal region to peroxia and hyperoxia-hypercapnia. Current Eye Res. 2000;21:669-676.
67. Wang S, Villegas-Perez MP, Holmes T, et al. Evolving neurovascular relationships in the RCS rat with age. Current Eye Res. 2003;27: 183-196.
68. Yu PK, Yu D-Y, Cringle SJ, Su E-N. Endothelial F-actin cytoskeleton in the retinal vasculature of normal and diabetic rats. Curr Eye Res. 2005;30:279-290.
69. Yu DY, Cringle S, Valter K, et al. Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Invest Ophthalmol Vis Sci. 2004;45:2013-2019.
70. Kang Derwent JJ, Padnick-Silver L, McRipley M, et al. The electro-retinogram components in Abyssinian cats with hereditary retinal degeneration. Invest Ophthalmol Vis Sci. 2006;47:3673-3682.
71. Padnick-Silver L, Kang Derwent JJ, Giuliano E, et al. Retinal oxygenation and oxygen metabolism in Abyssinian cats with a hereditary retinal degeneration. Invest Ophthalmol Vis Sci. 2006;47: 3683-3689.