Endothelial F-actin cytoskeleton in the retinal vasculature of normal and diabetic rats

Current Eye Research

Volumn 30, Issue 4, 2005, Pages 279-290

  Yu, Paula K ^a   Yu, Dao Yi ^a   Cringle, Stephen J ^a   Su, Er Ning ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Blood retinal barrier; Diabetic retinopathy; Endothelium; F actin cytoskeleton; Rat

Indexed keywords

F ACTIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DIABETIC RETINOPATHY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA BLOOD VESSEL; STREPTOZOCIN DIABETES; VASCULAR ENDOTHELIUM;

ACTINS; ANIMALS; BLOOD-RETINAL BARRIER; CAPILLARIES; CAPILLARY PERMEABILITY; CYTOSKELETON; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIUM, VASCULAR; MALE; MICROSCOPY, CONFOCAL; RATS; RATS, SPRAGUE-DAWLEY; RETINAL VESSELS;

EID: 20444406459     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680590923230     Document Type: Article

References (44)

1. Brown SM, Jampol LM. New concepts of regulation of retinal vessel tone. Arch Ophthalmol. 1996;114:199-204.
2. Meyer P, Haefliger IO, Flammer J, Luscher TF. Endothelium-dependent regulation in ocular vessels. In: Kaiser HJ, Flammer J, Hendrickson P, eds. Ocular Blood Flow. Basel: Karger, 1996:64-73.
3. Frank RN. Diabetic retinopathy. Prog Retina Eye Res. 1995;14:361-392.
4. Kohner EM. Diabetic retinopathy. BMJ. 1993;307:1195-1190.
5. Su EN, Yu DY, Alder VA, Yu PK, Cringle SJ. Altered vasoactivity in the early diabetic eye: Measured in the isolated perfused rat eye. Exp Eye Res. 1995;61:699-712.
6. Sinclair SH, Grunwald JE, Riva CE, Braunstein SN, Nichols CW. Retinal vascular autoregulation in diabetes mellitus. Ophthalmology. 1982;89:748-750.
7. Cringle SJ, Yu DY, Alder VA, Su EN. Retinal blood flow by hydrogen clearance polarography in the streptozotocin-induced diabetic rat. Invest Ophthalmol Vis Sci. 1993;34:1716-1721.
8. Qaum T, Xu Q, Joussen AM, Clements MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci. 2001;42:2408-2413.
9. Do cA, Ramos P, Reis A, Proenca R, Cunha-Vaz JG. Breakdown of the inner and outer blood retinal barrier in streptozotocin-induced diabetes. Exp Eye Res. 1998;67:569-575.
10. El Remessy AB, Behzadian MA, Abou-Mohamed G, Franklin T, Caldwell RW, Caldwell RB. Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am J Pathol. 2003;162:1995-2004.
11. Antonetti DA, Lieth E, Barber AJ, Gardner TW. Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol. 1999;14:240-248.
12. Terman BI, Dougher-Vermazen M. Biological properties of VEGF/VPF receptors. Cancer Metastasis Rev. 1996;15:159-163.
13. Pedram A, Razandi M, Levin ER. Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. J Biol Chem. 2002;277:44385-44398.
14. Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes. 1998;47:1953-1959.
15. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M. New insights into the pathophysiology of diabetic retinopathy: Potential cell-specific therapeutic targets. Diabetes Technol Ther. 2000;2:601-608.
16. Papadaki M, Eskin SG. Effects of fluid shea r stress on gene regulation of vascular cells. Biotechnol Progr. 1997;13:209-221.
17. Satcher R, Dewey CFJ, Hartwig JH. Mechanical remodeling of the endothelial surface and actin cytoskeleton induced by fluid flow. Microcirculation. 1997;4:439-453.
18. Davies PF. Endothelium as a signal transduction interface for flow forces: Cell surface dynamics. Thrombosis Haemostasis. 1993;70:124-128.
19. Satcher RL, Dewey CF. Theoretical estimates of mechanical properties of the endothelial cell cytoskeleton. Biophys J. 1996;71:109-118.
20. Schnittler HJ, Wilke A, Gress T, Suttorp N, Drenckhahn D. Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium. J Physiol. 1990;431:379-401.
21. Blum MS, Toninelli E, Anderson JM, Balda MS, Zhou J, O'Donnell L, Pardi R, Bender JR. Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. Am J Physiol. 1997;273:H286-H294.
22. Su E-N, Alder VA, Yu D-Y, Yu PK, Cringle SJ. Continued progression of retinopathy despite spontaneous recovery to normoglycemia in a long-term study of streptozotocin-induced diabetes in rats. Graefes Arch Clin Exp Ophthalmol. 2000;238:163-173.
23. Yu PK, Yu DY, Alder VA, Seydel U, Su EN, Cringle SJ. Heterogeneous endothelial cell structure along the porcine retinal microvasculature. Exp Eye Res. 1997;65:379-389.
24. Thurston G, Baldwin AL, Wilson LM. Changes in endothelial actin cytoskeleton at leakage sites in the rat mesenteric microvasculature. Am J Physiol. 1995;266:H316-H329.
25. Yu DY, Alder VA, Cringle SJ. Measurement of blood flow in rat eye by hydrogen clearance. Am J Physiol. 1991;261:H960-H968.
26. Kim DW, Gotlieb AI, Langille BL. In vivo modulation of endothelial F-actin microfilaments by experimental alterations in shear stress. Atherosclerosis. 1989;9:439-445.
27. Yu DY, Cringle SJ, Alder VA, Su EN. Intraretinal oxygen distribution in rats as a function of systemic blood pressure. Am J Physiol. 1994;36:H2498-H2507.
28. Yanoff M, Fine BS. In: Yanoff M, Fine BS, eds. Ocular Pathology a Text and Atlas. 3rd. ed. Philadelphia: J.B. Lippincott Company. 1989;1-737.
29. Nag S. Role of the endothelial cytoskeleton in blood-brain-barrier permeability to protein. Acta Neuropathol (Berl). 1995;90:454-460.
30. Vinores SA, Derevjanik NL, Mahlow J, Berkowitz BA, Wilson CA. Electron microscopic evidence for the mechanism of blood-retinal barrier breakdown in diabetic rabbits: Comparison with magnetic resonance imaging. Pathol Res Pract. 1998;194:497-505.
31. Ishibashi T, Inomata H. Ultrastructure of retinal vessels in diabetic patients. Br J Ophthalmol. 1993;77:574-578.
32. Carroll WJ, Mollis TM, Gardner TW. Retinal histamine synthesis is increased in experimental diabetes. Invest Ophthalmol Vis Sci. 1988;29:1201-1204.
33. Murata T, Nakagawa K, Khalil A, Ishibashi T, Inomata H, Sueishi K. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas. Lab Invest. 1996;74:819-825.
34. Hammes HP, Lin J, Bretzel RG, Brownlee M, Breier G. Up-regulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes. 1998;47:401-406.
35. Gilbert RE, Vranes D, Berka JL, Kelly DJ, Cox A, Wu LL, Stacker SA, Cooper ME. Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Lab Invest. 1998;78:1017-1027.
36. Murata T, Ishibashi T, Inomata H. Immunohistochemical detection of extravasated fibrinogen (fibrin) in human diabetic retina. Graefes Arch Clin Exp Ophthalmol. 1992;230:428-431.
37. Barber AJ, Antonetti DA, Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest Ophthalmol Vis Sci. 2003;44:5410-5416.
38. Berkowitz BA, Ito Y, Kern TS, McDonald C, Hawkins R. Correction of early subnormal superior hemiretinal DeltaPO(2) predicts therapeutic efficacy in experimental diabetic retinopathy. Invest Ophthalmol Vis Sci. 2001;42:2964-2969.
39. Nieuw Amerongen GP, Koolwijk P, Versteilen A, van Hinsbergh VW. Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. Arterioscler Thromb Vasc Biol. 2003;23:211-217.
40. Mompeo B, Popov D, Sima A, Constantinescu E, Simionescu M. Diabetes-induced structural changes of venous and arterial endothelium and smooth muscle cells. J Submicrosc Cytol Pathol. 1998;30:475-484.
41. Salwen SA, Szarowski DH, Turner JN, Bizios R. Three-dimensional changes of the cytoskeleton of vascular endothelial cells exposed to sustained hydrostatic pressure. Med Biol Eng Comput. 1998;36:520-527.
42. 2+ mobilization and cytoskeletal F-actin filaments in human cerebromicrovascular endothelial cells. J Cereb Blood Flow Metab. 1999;19:133-138.
43. Schmetterer L, Findl O, Strenn K, Jilma B, Graselli U, Eichler HG, Wolzt M. Effects of endothelin-1 (ET-T) on ocular hemodynamics. Curr Eye Res. 1997;16:687-692.
44. Spitaler MM, Graier WF Vascular targets of redox signalling in diabetes mellitus. Diabetologia. 2002;45:476-494.