Oxidative stress due to (R)-styrene oxide exposure and the role of antioxidants in non-swiss albino (NSA) mice

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 10, 2009, Pages 642-650

  Meszka Jordan, Anna ^a   Mahlapuu, Riina ^b   Soomets, Ursel ^b,c   Carlson, Gary P ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF TARTU   (Estonia)

^c Faculty of Medicine   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; BICINCHONINIC ACID; EPOXIDE; GLUTATHIONE; IDITOL DEHYDROGENASE; LACTATE DEHYDROGENASE; QUINOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RENT1 PROTEIN, MOUSE; STYRENE OXIDE; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; CELL COUNT; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DRUG EFFECT; LUNG DISEASE; LUNG LAVAGE; MALE; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; STEREOISOMERISM; TOXIC HEPATITIS;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; EPOXY COMPOUNDS; GLUTATHIONE; HEPATITIS, TOXIC; L-IDITOL 2-DEHYDROGENASE; L-LACTATE DEHYDROGENASE; LUNG DISEASES; MALE; MICE; OXIDATIVE STRESS; QUINOLINES; REACTIVE OXYGEN SPECIES; STEREOISOMERISM; TRANS-ACTIVATORS;

EID: 64049100594     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390902769436     Document Type: Article

References (36)

1. Agency for Toxic Substances and Disease Registry. 2008. Toxicological profile for styrene, Atlanta, GA: U.S. Department of Health and Human Services.
2. Boogaard, P. J., de Kloe, K. P., Wong, B. A., Sumner, S. C. J., Watson, W. P., and van Sittert, N. J. 2000. Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to 14C-styrene by nose-only inhalation. Toxicol. Sci. 57:203-216.
3. Carlson, G. P. 1997. Comparison of mouse strains for susceptibility to styreneinduced hepatotoxicity and pneumotoxicity. J. Toxicol. Environ. Health 51:177-187.
4. Carlson, G. P., Hynes, D. E., and Mantick, N. 1998. Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes. Toxicol. Lett. 98:131-137.
5. Cohen, J. T., Carlson, G., Charnley, G., Coggon, D., Delzell, E., Graham, J. D., Greim, H., Krewski, D., Medinsky, M., Monson, R., Paustenbach, D., Petersen, B., Rappaport, S., Rhomberg, L., Ryan, P. B., and Thompson, K. 2002. A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene. J. Toxicol. Environ. Health B 5:1-263.
6. Cruzan, G., Cushman, J. R., Andrews, L. S., Granville, G. C., Johnson, K. A., Bevan, C., Hardy, C. J., Coombs, D. W., Mullins, P. A., and Brown, W. R. 2001. Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks. J. Appl. Toxicol. 21:185-198.
7. Cruzan, G., Cushman, J. R., Andrews, L. S., Granville, G. C., Johnson, K. A., Hardy, C. J., Coombs, D. W., Mullins, P. A., and Brown, W. R. 1998. Chronic toxicity/oncogenicity study of styrene in CD rats by inhalation exposure for 104 weeks. Toxicol. Sci. 46:266-281.
8. Cruzan, G., Cushman, J. R., Andrews, L. S., Granville, G. C., Miller, R. R., Hardy, C. J., Coombs, D. W., and Mullins, P. A. 1997. Subchronic inhalation studies of styrene in CD rats and CD-1 mice. Fundam. Appl. Toxicol. 35:152-165.
9. Elovaara, E., Vainio, H., and Aitio, A. 1990. Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats. Arch. Toxicol. 64:365-369.
10. Gadberry, M. G., DeNicola, D. B., and Carlson, G. P. 1996. Pneumotoxicity and hepatotoxicity of styrene and styrene oxide. J. Toxicol. Environ. Health 48:273-294.
11. Gamer, A. O., Leibold, E., Deckardt, K., Kittel, B., Kaufmann, W., Tennekes, H. A., and van Ravenzwaay, B. 2004. The effects of styrene on lung cells in female mice and rats. Food Chem. Toxicol. 42:1655-1667.
12. Gerlach, U. 1983. Sorbitol dehydrogenase. In Methods of enzymatic analysis, ed. H. U. Bergmeyer, pp. 112-117. Weinheim: Verlag Chemie.
13. Gomez, M. R., Benzick, A. E., Rogers, L. K., Heird, W. C., and Smith, C. V. 1994. Attenuation of acetaminophen hepatotoxicity in mice as evidence for the bioavailability of the cysteine in D-glucose-L-cysteine in vivo. Toxicol. Lett. 70:101-108.
14. Harvilchuck, J. A., and Carlson, G. P. 2006. Comparison of styrene and its metabolites styrene oxide and 4-vinylphenol on cytotoxicity and glutathione depletion in Clara cells of mice and rats. Toxicology 227:165-172.
15. Harvilchuck, J. A., Zurbrugg, R. J., and Carlson, G. P. 2008. CC10 mRNA and protein expression in Clara cells of CD-1 mice following exposure to styrene or its metabolites styrene oxide or 4-vinylphenol. Toxicol. Lett. 183:28-35.
16. Hynes, D. E., DeNicola, D. B., and Carlson, G. P. 1999. Metabolism of styrene by mouse and rat isolated lung cells. Toxicol. Sci. 51:195-201.
17. Johanson, G., Ernstgard, L., Gullstrand, E., Lof, A., Osterman-Golkar, S., Williams, C. C., and Sumner, S. C. 2000. Styrene oxide in blood, hemoglobin adducts, and urinary metabolites in human volunteers exposed to (13)C(8)-styrene vapors. Toxicol. Appl. Pharmacol. 168:36-49.
18. Karelson, E., Mahlapuu, R., Zilmer, M., Soomets, U., Bogdanovic, N., and Langel, Ü. 2002. Possible signaling by glutathione and its novel analogue through potent stimulation of frontocortical G proteins in normal aging and in Alzheimer's disease. Ann. NY Acad. Sci. 973:537-540.
19. Kariya, C., Leitner, H., Min, E., van Heeckeren, C., van Heeckeren, A., and Day, B. J. 2007. A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration. Am. J. Physiol. Lung Cell Mol. Physiol. 292:L1590-L1597.
20. Kaufmann, W., Mellert, W., van Ravenzwaay, B., Landsiedel, R., and Poole, A. 2005. Effects of styrene and its metabolites on different lung compartments of the mouse - Cell proliferation and histomorphology. Regul. Toxicol. Pharmacol. 42:24-36.
21. McConnell, E. E., and Swenberg, J. A. 1993. Styrene and styrene oxide: Results of studies on carcinogenicity in experimental animals. IARC Sci. Publ. 127:323-333.
22. Morgan, D. L., Mahler, J. F., O'Connor, R. W., Price, H. C., and Adkins, B. 1993a. Styrene inhalation toxicity studies in mice. I. Hepatotoxicity in B6C3F1 mice. Fundam. Appl. Toxicol. 20:325-335.
23. Morgan, D. L., Mahler, J. F., Dill, J. A., Price, H. C., O'Connor, R. W., and Adkins, B. 1993b. Styrene inhalation toxicity studies in mice. II. Sex differences in susceptibility of B6C3F1 mice. Fundam. Appl. Toxicol. 21:317-325.
24. Pagano, D. A., Yagen, B., Hernandez, O., Bend, J. R., and Zeiger, E. 1982. Mutagenicity of (R) and (S) styrene 7,8-oxide and the intermediary mercapturic acid metabolites formed from styrene 7,8-oxide. Environ. Mutagen. 4:575-584.
25. Phillips, P. H., and Farmer, P. B. 1994. Evidence for DNA and protein binding by styrene and styrene oxide. Crit. Rev. Toxicol. 24(Suppl.):S35-S46.
26. Poder, P., Zimer, J., Starkopf, J., Kals, A., Talonpoika, A., Pulges, A., Langel, U., Kullisaar, T., Viirlaid, S., Mahlapuu, R., Zarkovski, A., Arend, A., and Soomets, U. 2004. An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. Neurosci. Lett. 370:45-50.
27. Ponomarkov, V., and Tomatis, L. 1978. Effects of long-term oral administration of styrene to mice and rats. Scand. J. Work Environ. Health 4:127-135.
28. Seiler, J. P. 1990. Chirality-dependent DNA reactivity as the possible cause of the differential mutagenicity of the two components in an enantiomeric pair of epoxides. Mutat. Res. 245:165-169.
29. Sinsheimer, J. E., Chen, R., Das, S. K., Hooberman, B. H., Osorio, S., and You, Z. 1993. The genotoxicity of enantiomeric aliphatic epoxides. Mutat. Res. 298:197-206.
30. Sumner, S. J., and Fennel, T. R. 1994. Review of the metabolic fate of styrene. Crit. Rev. Toxicol. 24:S11-S33.
31. Terneus, M. V., Kiningham, K. K., Carpenter, A. B., Sullivan, S. B., and Valentovic, M. A. 2007. Comparison of S-adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity. J. Pharmacol. Exp. Ther. 320:99-107.
32. Turner, M., Mantick, N. A., and Carlson, G. P. 2005. Comparison of the depletion of glutathione in mouse liver and lung following administration of styrene and its metabolites styrene oxide and 4-vinylphenol. Toxicology 206:383-388.
33. Vassault, A. 1983. Lactate dehydrogenase. UV-method with pyruvate and NADH. In Methods of enzymatic analysis, ed. H. U. Bergmeyer, 3rd ed., pp. 118-125. Weinheim: Verlag Chemie.
34. Vina, J., Perez, C., Furukawa, T., Palacin, M., and Vina, J. R. 1989. Effect of oral glutathione on hepatic glutathione levels in rats and mice. Br. J. Nutr. 62:683-691.
35. Vodicka, P., Koskinen, M., Arand, M., Oesch, F., and Hemminki, K. 2002. Spectrum of styrene-induced DNA adducts: The relationship to other biomarkers and prospects in human biomonitoring. Mutat. Res 511: 239-254.
36. Vodicka, P., Koskinene, M., Naccarati, A., Oesch-Bartlomowicz, B., Vodickova, L., Hemminki, K., and Osech, F. 2006. Styrene metabolism, genotoxicity, and potential carcinogenicity. Drug Metab. Rev. 38:805-853.