메뉴 건너뛰기




Volumn 35, Issue 3, 2009, Pages 246-254

Chemotherapy for colorectal cancer in the elderly: Whom to treat and what to use

Author keywords

Adjuvancy; Chemotherapy; Colorectal cancer; Elderly; Frailty

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CREATININE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LEVAMISOLE; OXALIPLATIN; PANITUMUMAB; RALTITREXED; UFT;

EID: 64049098470     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2008.11.004     Document Type: Review
Times cited : (19)

References (78)
  • 1
    • 16244403039 scopus 로고    scopus 로고
    • Cancer incidence and mortality in Europe 2004
    • Boyle P., and Ferlay J. Cancer incidence and mortality in Europe 2004. Ann Oncol 16 (2005) 481-488
    • (2005) Ann Oncol , vol.16 , pp. 481-488
    • Boyle, P.1    Ferlay, J.2
  • 2
    • 0034675248 scopus 로고    scopus 로고
    • Colorectal cancer collaborative group. Surgery for colorectal cancer in elderly patients: a systematic review
    • Colorectal cancer collaborative group. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 356 (2000) 968-974
    • (2000) Lancet , vol.356 , pp. 968-974
  • 3
    • 0035815928 scopus 로고    scopus 로고
    • Age and adjuvant chemotherapy use after surgery for stage III colon cancer
    • Schrag D., Cramer L.D., Bach P.B., and Begg C.B. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 93 (2001) 850-857
    • (2001) J Natl Cancer Inst , vol.93 , pp. 850-857
    • Schrag, D.1    Cramer, L.D.2    Bach, P.B.3    Begg, C.B.4
  • 4
    • 0038518557 scopus 로고    scopus 로고
    • Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?
    • Yee K.W., Pater J.L., Pho L., et al. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?. J Clin Oncol 21 (2003) 1618-1623
    • (2003) J Clin Oncol , vol.21 , pp. 1618-1623
    • Yee, K.W.1    Pater, J.L.2    Pho, L.3
  • 5
    • 34250155990 scopus 로고    scopus 로고
    • The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer
    • Gross C.P., McAvay G.J., Guo Z., and Tinetti M.E. The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer. Cancer 109 (2007) 2410-2419
    • (2007) Cancer , vol.109 , pp. 2410-2419
    • Gross, C.P.1    McAvay, G.J.2    Guo, Z.3    Tinetti, M.E.4
  • 7
    • 0345381933 scopus 로고    scopus 로고
    • The frailty syndrome: a critical issue in geriatric oncology
    • Ferruci L., Guralnik J.M., Cavazzini C., et al. The frailty syndrome: a critical issue in geriatric oncology. Crit Rev Oncol Hematol 46 (2003) 127-137
    • (2003) Crit Rev Oncol Hematol , vol.46 , pp. 127-137
    • Ferruci, L.1    Guralnik, J.M.2    Cavazzini, C.3
  • 8
    • 0033920730 scopus 로고    scopus 로고
    • Management of cancer in the older person: a practical approach
    • Balducci L., and Extermann M. Management of cancer in the older person: a practical approach. The Oncologist 5 (2000) 224-237
    • (2000) The Oncologist , vol.5 , pp. 224-237
    • Balducci, L.1    Extermann, M.2
  • 9
    • 0031901577 scopus 로고    scopus 로고
    • Comorbidity and functional status are independent in older cancer patients
    • Extermann M., Overcash J., Lyman G.H., et al. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 16 (1998) 1582-1587
    • (1998) J Clin Oncol , vol.16 , pp. 1582-1587
    • Extermann, M.1    Overcash, J.2    Lyman, G.H.3
  • 10
    • 26444551170 scopus 로고    scopus 로고
    • Clinical assessment of elderly people with cancer
    • Gosney M.A. Clinical assessment of elderly people with cancer. Lancet Oncol 6 (2005) 790-797
    • (2005) Lancet Oncol , vol.6 , pp. 790-797
    • Gosney, M.A.1
  • 11
    • 24044454968 scopus 로고    scopus 로고
    • Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the international society of geriatric oncology
    • Extermann M., Aapro M., Bernabei R., et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the international society of geriatric oncology. Crit Rev in Oncol Hematol 55 (2005) 241-252
    • (2005) Crit Rev in Oncol Hematol , vol.55 , pp. 241-252
    • Extermann, M.1    Aapro, M.2    Bernabei, R.3
  • 12
    • 2442699834 scopus 로고    scopus 로고
    • Frailty in older adults: evidence for a phenotype
    • Fried L.P., Tangen C.M., Waltson J., et al. Frailty in older adults: evidence for a phenotype. J Gerontol Med Sci 56A (2001) 146-156
    • (2001) J Gerontol Med Sci , vol.56 A , pp. 146-156
    • Fried, L.P.1    Tangen, C.M.2    Waltson, J.3
  • 13
    • 0038662715 scopus 로고    scopus 로고
    • Participation of patients 65 years of age or older in cancer clinical trials
    • Lewis J.H., Kilgore M.L., Goldman D.P., et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 21 (2003) 1383-1389
    • (2003) J Clin Oncol , vol.21 , pp. 1383-1389
    • Lewis, J.H.1    Kilgore, M.L.2    Goldman, D.P.3
  • 14
    • 12244298248 scopus 로고    scopus 로고
    • Colorectal cancer in the elderly: is palliative chemotherapy of value?
    • Honecker F., Kohne C.H., and Bokemeyer C. Colorectal cancer in the elderly: is palliative chemotherapy of value?. Drugs Aging 20 (2003) 1-11
    • (2003) Drugs Aging , vol.20 , pp. 1-11
    • Honecker, F.1    Kohne, C.H.2    Bokemeyer, C.3
  • 15
    • 34648834384 scopus 로고    scopus 로고
    • Dose intensity hematologic toxicity in older cancer patients receiving systemic chemotherapy
    • Shaine M., Culakova E., Poniewierski M.S., Wolff D., Dale D.C., Crawford J., et al. Dose intensity hematologic toxicity in older cancer patients receiving systemic chemotherapy. Cancer 110 (2007) 1611-1620
    • (2007) Cancer , vol.110 , pp. 1611-1620
    • Shaine, M.1    Culakova, E.2    Poniewierski, M.S.3    Wolff, D.4    Dale, D.C.5    Crawford, J.6
  • 16
    • 1842631407 scopus 로고    scopus 로고
    • Chemotherapy in the elderly
    • Lichtman S.M. Chemotherapy in the elderly. Semin Oncol 31 (2004) 160-174
    • (2004) Semin Oncol , vol.31 , pp. 160-174
    • Lichtman, S.M.1
  • 17
    • 0028819554 scopus 로고
    • Age and sex are independent factors of 5-fluorouracil toxicity: analysis of a large scale phase III trial
    • Stein B.N., Petrelli N.J., Dougass H.O., et al. Age and sex are independent factors of 5-fluorouracil toxicity: analysis of a large scale phase III trial. Cancer 75 (1995) 11-17
    • (1995) Cancer , vol.75 , pp. 11-17
    • Stein, B.N.1    Petrelli, N.J.2    Dougass, H.O.3
  • 18
    • 0036302615 scopus 로고    scopus 로고
    • Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate análisis of 3825 patients
    • Köhne C.H., Cunningham D., Di Costanzo F., et al. Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate análisis of 3825 patients. Ann Oncol 13 (2002) 308-317
    • (2002) Ann Oncol , vol.13 , pp. 308-317
    • Köhne, C.H.1    Cunningham, D.2    Di Costanzo, F.3
  • 19
    • 0036235128 scopus 로고    scopus 로고
    • First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
    • Cassidy J., Twelves C., Van Cutsem E., et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol 13 (2002) 566-575
    • (2002) Ann Oncol , vol.13 , pp. 566-575
    • Cassidy, J.1    Twelves, C.2    Van Cutsem, E.3
  • 20
    • 7944223833 scopus 로고    scopus 로고
    • Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
    • Chau I., Norman A.R., Cunningham D., et al. Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Brit J Cancer 91 (2004) 1453-1458
    • (2004) Brit J Cancer , vol.91 , pp. 1453-1458
    • Chau, I.1    Norman, A.R.2    Cunningham, D.3
  • 21
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg M.L., Cox J.V., De Vore F.R., et al. A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 85 (1999) 786-795
    • (1999) Cancer , vol.85 , pp. 786-795
    • Rothenberg, M.L.1    Cox, J.V.2    De Vore, F.R.3
  • 22
    • 2642529751 scopus 로고    scopus 로고
    • Is age a prognostic factor of toxicity and efficacy in patients with metastatic colorectal cancer receiving irinotecan in combination with 5FU/folinic acid (FA)
    • [abstract 1072]
    • Rougier P., Mitry E., Cunningham D., et al. Is age a prognostic factor of toxicity and efficacy in patients with metastatic colorectal cancer receiving irinotecan in combination with 5FU/folinic acid (FA). Proc Am Soc Clin Oncol 21 (2003) 267 [abstract 1072]
    • (2003) Proc Am Soc Clin Oncol , vol.21 , pp. 267
    • Rougier, P.1    Mitry, E.2    Cunningham, D.3
  • 23
    • 0042478012 scopus 로고    scopus 로고
    • Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G) in patients with previously treated colorectal cancer
    • Schaaf L., Ichpurani N., Elfring G., et al. Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G) in patients with previously treated colorectal cancer. Proc Am Soc Clin Oncol 15 (1997) 708
    • (1997) Proc Am Soc Clin Oncol , vol.15 , pp. 708
    • Schaaf, L.1    Ichpurani, N.2    Elfring, G.3
  • 24
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz L., Cox J., Blanke C., et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343 (2000) 905-914
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.1    Cox, J.2    Blanke, C.3
  • 25
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • De Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18 (2000) 2938-2947
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 26
    • 33748669385 scopus 로고    scopus 로고
    • Pooled analysis of safety and efficacy analysis of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer
    • Goldberg R.M., Tabah-Fisch I., Bleiberg H., et al. Pooled analysis of safety and efficacy analysis of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol 24 (2006) 4085-4091
    • (2006) J Clin Oncol , vol.24 , pp. 4085-4091
    • Goldberg, R.M.1    Tabah-Fisch, I.2    Bleiberg, H.3
  • 27
    • 33846705473 scopus 로고    scopus 로고
    • Single agent cetuximab for elderly patients with advanced colorectal cancer. Preliminary results of a TTD phase II study
    • [abstract 3240]
    • Sastre J., Aranda E., Gravalos C., et al. Single agent cetuximab for elderly patients with advanced colorectal cancer. Preliminary results of a TTD phase II study. Proc ESMO 17 (2006) 114 [abstract 3240]
    • (2006) Proc ESMO , vol.17 , pp. 114
    • Sastre, J.1    Aranda, E.2    Gravalos, C.3
  • 28
    • 65449187690 scopus 로고    scopus 로고
    • Cetuximab and irinotecan-based chemotherapy as an active and safe treatment option for elderly patients with extensively pre-treated metastatic colorectal cancer
    • [abstract 14528]
    • Bouchahda M., Macarulla T., Spano J.P., et al. Cetuximab and irinotecan-based chemotherapy as an active and safe treatment option for elderly patients with extensively pre-treated metastatic colorectal cancer. Proc Am Soc Clin Oncol (2007) 25 [abstract 14528]
    • (2007) Proc Am Soc Clin Oncol , pp. 25
    • Bouchahda, M.1    Macarulla, T.2    Spano, J.P.3
  • 29
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitunumab plus best supportive care compared with best supportive care alone in patients with chemotherapy - refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., et al. Open-label phase III trial of panitunumab plus best supportive care compared with best supportive care alone in patients with chemotherapy - refractory metastatic colorectal cancer. J Clin Oncol 25 (2007) 1658-1664
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 30
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci F.A., Skillings J.R., Holden S.N., et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 99 (2007) 1232-1239
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 31
    • 0025060806 scopus 로고
    • Levamisole and fluorouracil as adjuvant therapy of resected colon carcinoma
    • Moertel C.G., Fleming T.R., MacDonald J.S., et al. Levamisole and fluorouracil as adjuvant therapy of resected colon carcinoma. N Engl J Med 322 (1990) 352-358
    • (1990) N Engl J Med , vol.322 , pp. 352-358
    • Moertel, C.G.1    Fleming, T.R.2    MacDonald, J.S.3
  • 32
    • 0029644482 scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International multicentre pooled análisis of colon cancer trials (IMPACT) investigators
    • Anonymous. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International multicentre pooled análisis of colon cancer trials (IMPACT) investigators. Lancet 345 (1995) 939-944
    • (1995) Lancet , vol.345 , pp. 939-944
  • 33
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • André T., Boni C., Mounedji-Boudiaf L., et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350 (2004) 2343-2351
    • (2004) N Engl J Med , vol.350 , pp. 2343-2351
    • André, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 34
    • 34250210799 scopus 로고    scopus 로고
    • Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07
    • Kuebler J.P., Wieand H.S., ÓConnell M.J., et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 25 (2007) 2198-2204
    • (2007) J Clin Oncol , vol.25 , pp. 2198-2204
    • Kuebler, J.P.1    Wieand, H.S.2    ÓConnell, M.J.3
  • 35
    • 28844482345 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation
    • Jessup J.M., Stewart A., Greene F.L., and Minsky B.D. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. JAMA 294 (2005) 2758-2760
    • (2005) JAMA , vol.294 , pp. 2758-2760
    • Jessup, J.M.1    Stewart, A.2    Greene, F.L.3    Minsky, B.D.4
  • 36
    • 0035846320 scopus 로고    scopus 로고
    • A pooled analysis of adjuvant chemotherapy for resected colon cancer in the elderly
    • Sargent D.J., Goldberg R.M., Jacobson S.D., and Macdonald J.S. A pooled analysis of adjuvant chemotherapy for resected colon cancer in the elderly. N Engl J Med 345 (2001) 1091-1097
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1    Goldberg, R.M.2    Jacobson, S.D.3    Macdonald, J.S.4
  • 38
    • 20044370090 scopus 로고    scopus 로고
    • Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender and comorbidity
    • Lemmens V.E.P.P., van Halteren A.H., Janssen-Heijnen M.L., et al. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender and comorbidity. Ann Oncol 16 (2005) 767-772
    • (2005) Ann Oncol , vol.16 , pp. 767-772
    • Lemmens, V.E.P.P.1    van Halteren, A.H.2    Janssen-Heijnen, M.L.3
  • 39
    • 33847719115 scopus 로고    scopus 로고
    • Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients
    • Morris M., Platell C., Fritschi L., and Iacopetta B. Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients. Brit J Cancer 96 (2007) 701-707
    • (2007) Brit J Cancer , vol.96 , pp. 701-707
    • Morris, M.1    Platell, C.2    Fritschi, L.3    Iacopetta, B.4
  • 40
    • 33749161222 scopus 로고    scopus 로고
    • Patterns of care for adjuvant therapy in a random population-based sample of patients diagnosed with colorectal cancer
    • Cronin D.P., Harlan L.C., Potosky A.L., et al. Patterns of care for adjuvant therapy in a random population-based sample of patients diagnosed with colorectal cancer. Am J Gastroenterol 101 (2006) 2308-2318
    • (2006) Am J Gastroenterol , vol.101 , pp. 2308-2318
    • Cronin, D.P.1    Harlan, L.C.2    Potosky, A.L.3
  • 41
    • 34249781969 scopus 로고    scopus 로고
    • Managing older patients with colorectal cancer
    • Sanoff H.K., Bleiberg H., and Goldberg R.M. Managing older patients with colorectal cancer. J Clin Oncol 25 (2007) 1891-1897
    • (2007) J Clin Oncol , vol.25 , pp. 1891-1897
    • Sanoff, H.K.1    Bleiberg, H.2    Goldberg, R.M.3
  • 42
    • 33750936956 scopus 로고    scopus 로고
    • The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening
    • Gross C.P., McAvay G.J., Krumholz H.M., et al. The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening. Ann Int Med 145 (2006) 646-653
    • (2006) Ann Int Med , vol.145 , pp. 646-653
    • Gross, C.P.1    McAvay, G.J.2    Krumholz, H.M.3
  • 43
    • 33646443236 scopus 로고    scopus 로고
    • Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from national surgical adjuvant breast and bowel project protocol C-06
    • Lembersky B.C., Wieand H.S., Petrelli N.J., et al. Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from national surgical adjuvant breast and bowel project protocol C-06. J Clin Oncol 24 (2006) 2059-2064
    • (2006) J Clin Oncol , vol.24 , pp. 2059-2064
    • Lembersky, B.C.1    Wieand, H.S.2    Petrelli, N.J.3
  • 45
    • 20944436646 scopus 로고    scopus 로고
    • A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of proctracted venous infusion fluorouracil as adjuvant treatment in colorectal cancer
    • Chau I., Norman A.R., Cunningham D., et al. A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of proctracted venous infusion fluorouracil as adjuvant treatment in colorectal cancer. Ann Oncol 16 (2005) 549-557
    • (2005) Ann Oncol , vol.16 , pp. 549-557
    • Chau, I.1    Norman, A.R.2    Cunningham, D.3
  • 46
    • 33744831506 scopus 로고    scopus 로고
    • Duration of adjuvant chemotherapy for colon cancer and survival among elderly
    • Neugut A.I., Matasar M., Wang X., et al. Duration of adjuvant chemotherapy for colon cancer and survival among elderly. J Clin Oncol 24 (2006) 2368-2375
    • (2006) J Clin Oncol , vol.24 , pp. 2368-2375
    • Neugut, A.I.1    Matasar, M.2    Wang, X.3
  • 48
    • 17644382288 scopus 로고    scopus 로고
    • Critical evaluation of current treatments in metastatic colorectal cancer
    • Venook A. Critical evaluation of current treatments in metastatic colorectal cancer. The Oncologist 10 (2005) 250-261
    • (2005) The Oncologist , vol.10 , pp. 250-261
    • Venook, A.1
  • 49
    • 48749102117 scopus 로고    scopus 로고
    • Irinotecan/5-FU/FA (I-FU) or FU/FA (FU) first-line therapy in older and younger patients with metastatic colorectal cancer: combined analysis of 2.691 patients in randomized controlled trials
    • [abstract 4071]
    • Folprecht G., Seymour T., Saltz L., Douillard J.Y., Stephens R.J., Van Cutsem E., et al. Irinotecan/5-FU/FA (I-FU) or FU/FA (FU) first-line therapy in older and younger patients with metastatic colorectal cancer: combined analysis of 2.691 patients in randomized controlled trials. Proc Am Soc Clin Oncol 25 (2007) 181 [abstract 4071]
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 181
    • Folprecht, G.1    Seymour, T.2    Saltz, L.3    Douillard, J.Y.4    Stephens, R.J.5    Van Cutsem, E.6
  • 50
    • 0141465154 scopus 로고    scopus 로고
    • Are older French patients as willing as older American patients to undertake chemotherapy?
    • Extermann M., Albrand G., Chen H., et al. Are older French patients as willing as older American patients to undertake chemotherapy?. J Clin Oncol 21 (2003) 3214-3219
    • (2003) J Clin Oncol , vol.21 , pp. 3214-3219
    • Extermann, M.1    Albrand, G.2    Chen, H.3
  • 51
    • 0027997825 scopus 로고
    • Age and clinical decision making in oncology patients
    • Yellen S.B., Cella D.F., and Leslie W.T. Age and clinical decision making in oncology patients. J Natl Inst 86 (1994) 1766-1770
    • (1994) J Natl Inst , vol.86 , pp. 1766-1770
    • Yellen, S.B.1    Cella, D.F.2    Leslie, W.T.3
  • 52
    • 36849087805 scopus 로고    scopus 로고
    • Desire for information and involvement in treatment decisions; elderly cancer patientś preferences and their physicianśperceptions
    • Elkin E.B., Kim H.M., Casper E.S., Kissane D.W., and Schrag D. Desire for information and involvement in treatment decisions; elderly cancer patientś preferences and their physicianśperceptions. J Clin Oncol 25 (2007) 5375-5380
    • (2007) J Clin Oncol , vol.25 , pp. 5375-5380
    • Elkin, E.B.1    Kim, H.M.2    Casper, E.S.3    Kissane, D.W.4    Schrag, D.5
  • 53
    • 0032730143 scopus 로고    scopus 로고
    • Multicenter phase II study of bimonthly high dose leucovorin, fluorouracil infusion and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen
    • André T., Bansmaine M.A., Louvet C., et al. Multicenter phase II study of bimonthly high dose leucovorin, fluorouracil infusion and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen. J Clin Oncol 17 (1999) 3560-3568
    • (1999) J Clin Oncol , vol.17 , pp. 3560-3568
    • André, T.1    Bansmaine, M.A.2    Louvet, C.3
  • 54
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma
    • Comella P., Natale D., Farris A., et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma. Cancer 104 (2005) 282-289
    • (2005) Cancer , vol.104 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3
  • 55
    • 33645731984 scopus 로고    scopus 로고
    • XELOX (Capecitabine plus Oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer
    • Feliu J., Salud A., Escudero P., et al. XELOX (Capecitabine plus Oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer. Brit J Cancer 94 (2006) 969-975
    • (2006) Brit J Cancer , vol.94 , pp. 969-975
    • Feliu, J.1    Salud, A.2    Escudero, P.3
  • 56
    • 37049022436 scopus 로고    scopus 로고
    • FOLFOX in patients aged between 78 and 80 years with metastatic colorectal cancer. An exploratory cohort of the OPTIMOX study
    • Figer A., Perez N., Carola E., Tournigand C., Lledo G., Flesch M., et al. FOLFOX in patients aged between 78 and 80 years with metastatic colorectal cancer. An exploratory cohort of the OPTIMOX study. Cancer 110 (2007) 2666-2671
    • (2007) Cancer , vol.110 , pp. 2666-2671
    • Figer, A.1    Perez, N.2    Carola, E.3    Tournigand, C.4    Lledo, G.5    Flesch, M.6
  • 57
    • 25444442283 scopus 로고    scopus 로고
    • High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer
    • Mattioli R., Massacesi C., Recchia F., et al. High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer. Ann Oncol 16 (2005) 1147-1151
    • (2005) Ann Oncol , vol.16 , pp. 1147-1151
    • Mattioli, R.1    Massacesi, C.2    Recchia, F.3
  • 58
    • 20644437768 scopus 로고    scopus 로고
    • Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study
    • Sastre J., Marcuello E., Massutti B., et al. Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study. J Clin Oncol 23 (2005) 3545-3551
    • (2005) J Clin Oncol , vol.23 , pp. 3545-3551
    • Sastre, J.1    Marcuello, E.2    Massutti, B.3
  • 59
    • 29144469349 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: a phase II trial
    • Souglakos J., Pallis A., Kakolyris D., et al. Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: a phase II trial. Oncology 69 (2005) 384-390
    • (2005) Oncology , vol.69 , pp. 384-390
    • Souglakos, J.1    Pallis, A.2    Kakolyris, D.3
  • 60
    • 25444443120 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients
    • Rosati G., Cordio S., Tucci A., et al. Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients. Oncology 69 (2005) 122-129
    • (2005) Oncology , vol.69 , pp. 122-129
    • Rosati, G.1    Cordio, S.2    Tucci, A.3
  • 61
    • 0242408138 scopus 로고    scopus 로고
    • Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly
    • Aparicio T., Desrame J., Lecomte T., et al. Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly. Brit J Cancer 89 (2003) 1439-1444
    • (2003) Brit J Cancer , vol.89 , pp. 1439-1444
    • Aparicio, T.1    Desrame, J.2    Lecomte, T.3
  • 62
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop- and- go fashion in advanced colorectal cancer-A GERCOR Study
    • Tournigand C., Cervantes A., Figer A., et al. OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop- and- go fashion in advanced colorectal cancer-A GERCOR Study. J Clin Oncol 24 (2006) 394-400
    • (2006) J Clin Oncol , vol.24 , pp. 394-400
    • Tournigand, C.1    Cervantes, A.2    Figer, A.3
  • 63
    • 33750904099 scopus 로고    scopus 로고
    • Randomized double blind (DB) placebo (Plcb) controlled phase III study assessing the efficacy of xaliproden (X) in reducing the cumulative peripheral sensory neuropathy (PSN) induced by the oxaliplatin (Ox) and 5-FU/LV combination (FOLFOX4) in first line treatment of patients (pts) with metastatic colorectal cancer (MCRC)
    • [abstract 3507]
    • Cassidy J., Bjarnason G.A., Hickish T., et al. Randomized double blind (DB) placebo (Plcb) controlled phase III study assessing the efficacy of xaliproden (X) in reducing the cumulative peripheral sensory neuropathy (PSN) induced by the oxaliplatin (Ox) and 5-FU/LV combination (FOLFOX4) in first line treatment of patients (pts) with metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 26 (2006) 147 [abstract 3507]
    • (2006) Proc Am Soc Clin Oncol , vol.26 , pp. 147
    • Cassidy, J.1    Bjarnason, G.A.2    Hickish, T.3
  • 64
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
    • Cassidy J., Tabernero J., Twelves C., et al. XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol 22 (2004) 2084-2091
    • (2004) J Clin Oncol , vol.22 , pp. 2084-2091
    • Cassidy, J.1    Tabernero, J.2    Twelves, C.3
  • 66
    • 0141956315 scopus 로고    scopus 로고
    • Irinotecan plus leucovorin-modulated 5-fluorouracil I. V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma
    • Comella P., Farris A., Lorusso V., et al. Irinotecan plus leucovorin-modulated 5-fluorouracil I. V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma. Br J Cancer 89 (2003) 992-996
    • (2003) Br J Cancer , vol.89 , pp. 992-996
    • Comella, P.1    Farris, A.2    Lorusso, V.3
  • 67
    • 34547097252 scopus 로고    scopus 로고
    • Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX). Intergroup trial N9741 in forst-line treatment of metastatic colorectal cancer
    • Ashley A.C., Sargent D.J., Alberts S.R., et al. Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX). Intergroup trial N9741 in forst-line treatment of metastatic colorectal cancer. Cancer 110 (2007) 670-677
    • (2007) Cancer , vol.110 , pp. 670-677
    • Ashley, A.C.1    Sargent, D.J.2    Alberts, S.R.3
  • 69
    • 34447255724 scopus 로고    scopus 로고
    • Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial
    • Seymour M.T., Maughan T.S., Ledermann J.A., et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial. Lancet 370 (2007) 143-152
    • (2007) Lancet , vol.370 , pp. 143-152
    • Seymour, M.T.1    Maughan, T.S.2    Ledermann, J.A.3
  • 70
    • 34447277453 scopus 로고    scopus 로고
    • Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial
    • Koopman M., Antonini N.F., Douma J., et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet 370 (2007) 135-142
    • (2007) Lancet , vol.370 , pp. 135-142
    • Koopman, M.1    Antonini, N.F.2    Douma, J.3
  • 71
    • 43549084892 scopus 로고    scopus 로고
    • Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: the FOCUS2 trial
    • Seymour M.T., Maughan T.S., Wasan H.S., et al. Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: the FOCUS2 trial. Proc Am Soc Clin Oncol 28 (2007) 9030
    • (2007) Proc Am Soc Clin Oncol , vol.28 , pp. 9030
    • Seymour, M.T.1    Maughan, T.S.2    Wasan, H.S.3
  • 72
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-a GERCOR study
    • Tournigand C., Cervantes A., Figer A., et al. OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-a GERCOR study. J Clin Oncol 24 (2006) 394-400
    • (2006) J Clin Oncol , vol.24 , pp. 394-400
    • Tournigand, C.1    Cervantes, A.2    Figer, A.3
  • 73
    • 1842409638 scopus 로고    scopus 로고
    • Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz cooperative group
    • Feliu J., González-Barón M., Espinosa E., et al. Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz cooperative group. Cancer 79 (1997) 1884-1889
    • (1997) Cancer , vol.79 , pp. 1884-1889
    • Feliu, J.1    González-Barón, M.2    Espinosa, E.3
  • 74
    • 0030834502 scopus 로고    scopus 로고
    • UFT plus folinic acid as therapy for metastatic colorectal cancer in older patients
    • Abad A. UFT plus folinic acid as therapy for metastatic colorectal cancer in older patients. Oncology 11 (1999) 53-57
    • (1999) Oncology , vol.11 , pp. 53-57
    • Abad, A.1
  • 75
    • 36849089518 scopus 로고    scopus 로고
    • Phase II study of Uracil-Tegafur with Leucovorin in elderly (≥75 years old) patients with colorectal cancer: ECOG 1299
    • Hochster H., Luo W., Popa E.C., et al. Phase II study of Uracil-Tegafur with Leucovorin in elderly (≥75 years old) patients with colorectal cancer: ECOG 1299. J Clin Oncol 25 (2007) 5397-5402
    • (2007) J Clin Oncol , vol.25 , pp. 5397-5402
    • Hochster, H.1    Luo, W.2    Popa, E.C.3
  • 76
    • 0036270715 scopus 로고    scopus 로고
    • Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: an active and low toxicity regimen
    • Feliu J., Mel J.R., Camps C., et al. Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: an active and low toxicity regimen. Eur J Cancer 38 (2002) 1204-1211
    • (2002) Eur J Cancer , vol.38 , pp. 1204-1211
    • Feliu, J.1    Mel, J.R.2    Camps, C.3
  • 77
    • 21144452813 scopus 로고    scopus 로고
    • Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an oncopaz cooperative group study
    • Feliu J., Escudero P., Llosa F., et al. Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an oncopaz cooperative group study. J Cin Oncol 23 (2005) 3104-3111
    • (2005) J Cin Oncol , vol.23 , pp. 3104-3111
    • Feliu, J.1    Escudero, P.2    Llosa, F.3
  • 78
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial
    • Kabbinavar F.F., Schultz J., McCleod M., et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 23 (2005) 3697-3705
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schultz, J.2    McCleod, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.